FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075103313> ?p ?o ?g. }

• W2075103313 endingPage "217" @default.
• W2075103313 startingPage "211" @default.
• W2075103313 abstract "Amplification of the MDM2 gene, which maps to chromosome band 12q13 and encodes a p53-binding protein, may result in functional inactivation of p53 and has been observed in various bone and soft tissue sarcomas. Published studies have included few cases of Ewing's sarcoma (ES) or peripheral neuroectodermal tumour (PNET), a tumour group in which alterations of the p53 pathway have so far not been extensively studied. We examined two ES cell lines, RD-ES and SK-ES-1, and 30 specimens from 27 patients (24 ES, 6 PNET; 19 primary, 4 local recurrence, 7 metastasis) for MDM2 gene amplification by Southern blot analysis. All 30 clinical specimens had been confirmed to contain sufficient ES/PNET DNA by the demonstration of a rearrangement of the t(11;22)-associated EWS gene using an EWS cDNA probe on the same blots. MDM2 gene amplification was detected in 3 of 30 specimens (10 per cent), including two ES and one PNET, but in neither of the cell lines. The three cases with amplification were morphologically typical primary tumours. Two of the three cases also showed co-amplification of the CDK4 gene, which endoces a cyclin-dependent kinase and also maps to band 12q13. Clinically, all three cases had metastatic disease at diagnosis, compared with only 1 of 15 MDM2-negative cases where the primary tumour was studied. The difference was statistically significant (P=0.005), suggesting an association of MDM2 amplification with advanced stage. Further accural and multivariate analysis of ES/PNET cases with MDM2 gene amplification will be necessary to confirm the clinical significance of these findings. The results suggest that the prevalence of MDM2 gene amplification in ES/PNET is comparable to other sarcomas, and implicate dysfunction of the p53 pathway in a subset of ES/PNET. The biological significance of CDK4 co-amplification remains to be determined." @default.
• W2075103313 created "2016-06-24" @default.
• W2075103313 creator A5017081282 @default.
• W2075103313 creator A5017517597 @default.
• W2075103313 creator A5022207361 @default.
• W2075103313 creator A5030239715 @default.
• W2075103313 creator A5046345178 @default.
• W2075103313 creator A5067230136 @default.
• W2075103313 date "1995-02-01" @default.
• W2075103313 modified "2023-10-18" @default.
• W2075103313 title "MDM2 andCDK4 gene amplification in Ewing's sarcoma" @default.
• W2075103313 cites W1535148719 @default.
• W2075103313 cites W1576330810 @default.
• W2075103313 cites W1965173366 @default.
• W2075103313 cites W1971245466 @default.
• W2075103313 cites W1975324295 @default.
• W2075103313 cites W1983348452 @default.
• W2075103313 cites W1990582989 @default.
• W2075103313 cites W1991865265 @default.
• W2075103313 cites W1997073961 @default.
• W2075103313 cites W2015519364 @default.
• W2075103313 cites W2022822433 @default.
• W2075103313 cites W2026853588 @default.
• W2075103313 cites W2027558915 @default.
• W2075103313 cites W2038211730 @default.
• W2075103313 cites W2043516602 @default.
• W2075103313 cites W2063602321 @default.
• W2075103313 cites W2064823686 @default.
• W2075103313 cites W2067368732 @default.
• W2075103313 cites W2068402552 @default.
• W2075103313 cites W2069351898 @default.
• W2075103313 cites W2089218510 @default.
• W2075103313 cites W2091151265 @default.
• W2075103313 cites W2099907467 @default.
• W2075103313 cites W2137124052 @default.
• W2075103313 cites W2330923897 @default.
• W2075103313 doi "https://doi.org/10.1002/path.1711750209" @default.
• W2075103313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7738717" @default.
• W2075103313 hasPublicationYear "1995" @default.
• W2075103313 type Work @default.
• W2075103313 sameAs 2075103313 @default.
• W2075103313 citedByCount "89" @default.
• W2075103313 countsByYear W20751033132012 @default.
• W2075103313 countsByYear W20751033132013 @default.
• W2075103313 countsByYear W20751033132014 @default.
• W2075103313 countsByYear W20751033132015 @default.
• W2075103313 countsByYear W20751033132016 @default.
• W2075103313 countsByYear W20751033132017 @default.
• W2075103313 countsByYear W20751033132018 @default.
• W2075103313 countsByYear W20751033132019 @default.
• W2075103313 countsByYear W20751033132023 @default.
• W2075103313 crossrefType "journal-article" @default.
• W2075103313 hasAuthorship W2075103313A5017081282 @default.
• W2075103313 hasAuthorship W2075103313A5017517597 @default.
• W2075103313 hasAuthorship W2075103313A5022207361 @default.
• W2075103313 hasAuthorship W2075103313A5030239715 @default.
• W2075103313 hasAuthorship W2075103313A5046345178 @default.
• W2075103313 hasAuthorship W2075103313A5067230136 @default.
• W2075103313 hasConcept C104317684 @default.
• W2075103313 hasConcept C121608353 @default.
• W2075103313 hasConcept C133307689 @default.
• W2075103313 hasConcept C142724271 @default.
• W2075103313 hasConcept C153911025 @default.
• W2075103313 hasConcept C174475383 @default.
• W2075103313 hasConcept C2776192174 @default.
• W2075103313 hasConcept C2777586341 @default.
• W2075103313 hasConcept C2778256501 @default.
• W2075103313 hasConcept C2779013556 @default.
• W2075103313 hasConcept C30481170 @default.
• W2075103313 hasConcept C502942594 @default.
• W2075103313 hasConcept C53226629 @default.
• W2075103313 hasConcept C54355233 @default.
• W2075103313 hasConcept C71924100 @default.
• W2075103313 hasConcept C7602840 @default.
• W2075103313 hasConcept C86803240 @default.
• W2075103313 hasConceptScore W2075103313C104317684 @default.
• W2075103313 hasConceptScore W2075103313C121608353 @default.
• W2075103313 hasConceptScore W2075103313C133307689 @default.
• W2075103313 hasConceptScore W2075103313C142724271 @default.
• W2075103313 hasConceptScore W2075103313C153911025 @default.
• W2075103313 hasConceptScore W2075103313C174475383 @default.
• W2075103313 hasConceptScore W2075103313C2776192174 @default.
• W2075103313 hasConceptScore W2075103313C2777586341 @default.
• W2075103313 hasConceptScore W2075103313C2778256501 @default.
• W2075103313 hasConceptScore W2075103313C2779013556 @default.
• W2075103313 hasConceptScore W2075103313C30481170 @default.
• W2075103313 hasConceptScore W2075103313C502942594 @default.
• W2075103313 hasConceptScore W2075103313C53226629 @default.
• W2075103313 hasConceptScore W2075103313C54355233 @default.
• W2075103313 hasConceptScore W2075103313C71924100 @default.
• W2075103313 hasConceptScore W2075103313C7602840 @default.
• W2075103313 hasConceptScore W2075103313C86803240 @default.
• W2075103313 hasIssue "2" @default.
• W2075103313 hasLocation W20751033131 @default.
• W2075103313 hasLocation W20751033132 @default.
• W2075103313 hasOpenAccess W2075103313 @default.
• W2075103313 hasPrimaryLocation W20751033131 @default.
• W2075103313 hasRelatedWork W1918281504 @default.

• next