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- W2075115630 abstract "Abstract Human Dectin-1 (hDectin-1) is a member of the C-type lectin–like receptor family that was shown to be the major receptor for fungal beta-glucans and to play an important role in the cellular responses mediated by these carbohydrates. In this study, we demonstrate that hDectin-1 is involved in the uptake and cross-presentation of cellular antigens. Furthermore, activation of monocyte-derived dendritic cells (MDCs) with toll-like receptor 3 (TLR3) ligand but not with TLR2 ligand or TLR7 ligand resulted in down-regulation of hDectin-1 expression and reduced phagocytosis of apoptotic tumor cells as well as presentation of pp65-derived T-cell epitopes upon engulfment of cytomegalovirus (CMV)–infected human foreskin fibroblasts." @default.
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- W2075115630 date "2008-04-15" @default.
- W2075115630 modified "2023-10-01" @default.
- W2075115630 title "hDectin-1 is involved in uptake and cross-presentation of cellular antigens" @default.
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- W2075115630 doi "https://doi.org/10.1182/blood-2006-10-051375" @default.
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