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- W2075116520 abstract "<i>Purpose:</i> To evaluate the effects of mitomycin C and amniotic membrane transplantation on the modulation of wound healing after glaucoma filtration surgery. <i>Methods:</i> Trabeculectomy was performed in 3 groups of 10 rabbit eyes each. Sponges soaked in mitomycin C were applied to the first group, and amniotic membranes were transplanted around the scleral flap in the second group; the third group was the control. The arithmetic means of fibroblast and macrophage numbers per square centimetre were calculated. <i>Results:</i> The mean numbers of fibroblasts and macrophages were decreased significantly in the mitomycin C group, compared with the controls (p < 0.0001). Cell counts in the amniotic membrane group were also lower than the ones in the control group for fibroblasts and macrophages (p < 0.0001, p < 0.01, respectively). The difference between the two treatment groups was statistically significant for fibroblasts (p < 0.0001), but not significant for macrophages (p > 0.05). <i>Conclusion:</i> In spite of the fact that amniotic membrane transplantation is less effective than mitomycin C for depressing wound healing after trabeculectomy, it might be a safer alternative in selected cases when considering severe adverse effects of antimetabolites." @default.
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- W2075116520 date "2002-01-01" @default.
- W2075116520 modified "2023-09-27" @default.
- W2075116520 title "Effects of Amniotic Membrane Transplantation and Mitomycin C on Wound Healing in Experimental Glaucoma Surgery" @default.
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- W2075116520 doi "https://doi.org/10.1159/000067550" @default.
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