FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075120289> ?p ?o ?g. }

• W2075120289 endingPage "6006" @default.
• W2075120289 startingPage "6002" @default.
• W2075120289 abstract "Renal medullary cells contain high concentrations of myo-inositol, sorbitol, betaine, and glycerophosphocholine, whose levels vary with urinary osmolality. Accumulation of these compatible organic osmolytes is believed to help the cells osmoregulate in response to the high extracellular osmolality that occurs as part of the urinary concentrating mechanism. MDCK cells (a line from dog kidney) were previously shown to accumulate myo-inositol in response to increased medium osmolality. We demonstrate here that this accumulation requires the presence of myo-inositol in the medium, implying that the myo-inositol is not synthesized by the cells but rather is transported into them from the extracellular solution. The MDCK cells contain sodium-dependent myo-inositol transporters. Relative to isotonic controls, sodium-dependent myo-inositol uptake is higher in cells exposed to increased osmolality either acutely (1-7 days) or chronically (greater than 1 year). Transport is further enhanced when the cells are cultured in myo-inositol-free medium. The transport has both high- and low-affinity components. The observed changes in transport involve changes in maximal velocity of the high-affinity component but not in its Km. We conclude that renal cells can osmoregulate by changing the number (or, less likely, the transport turnover rate) of functioning sodium-dependent myo-inositol transporters." @default.
• W2075120289 created "2016-06-24" @default.
• W2075120289 creator A5025916093 @default.
• W2075120289 creator A5052810142 @default.
• W2075120289 creator A5091017979 @default.
• W2075120289 date "1989-08-01" @default.
• W2075120289 modified "2023-09-25" @default.
• W2075120289 title "Osmoregulatory changes in myo-inositol transport by renal cells." @default.
• W2075120289 cites W1501725220 @default.
• W2075120289 cites W1577149434 @default.
• W2075120289 cites W192700678 @default.
• W2075120289 cites W1967159904 @default.
• W2075120289 cites W1981305491 @default.
• W2075120289 cites W1984428004 @default.
• W2075120289 cites W1986115510 @default.
• W2075120289 cites W1989756704 @default.
• W2075120289 cites W1996589652 @default.
• W2075120289 cites W2016379729 @default.
• W2075120289 cites W2021112867 @default.
• W2075120289 cites W2035565266 @default.
• W2075120289 cites W2043371256 @default.
• W2075120289 cites W2068710028 @default.
• W2075120289 cites W2073294284 @default.
• W2075120289 cites W2096725836 @default.
• W2075120289 cites W2108715680 @default.
• W2075120289 cites W2328310299 @default.
• W2075120289 cites W2415535951 @default.
• W2075120289 cites W2415951527 @default.
• W2075120289 cites W2465468566 @default.
• W2075120289 cites W2469066056 @default.
• W2075120289 doi "https://doi.org/10.1073/pnas.86.15.6002" @default.
• W2075120289 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/297760" @default.
• W2075120289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2762310" @default.
• W2075120289 hasPublicationYear "1989" @default.
• W2075120289 type Work @default.
• W2075120289 sameAs 2075120289 @default.
• W2075120289 citedByCount "121" @default.
• W2075120289 countsByYear W20751202892012 @default.
• W2075120289 countsByYear W20751202892013 @default.
• W2075120289 countsByYear W20751202892014 @default.
• W2075120289 countsByYear W20751202892015 @default.
• W2075120289 countsByYear W20751202892016 @default.
• W2075120289 countsByYear W20751202892017 @default.
• W2075120289 countsByYear W20751202892018 @default.
• W2075120289 countsByYear W20751202892019 @default.
• W2075120289 countsByYear W20751202892020 @default.
• W2075120289 countsByYear W20751202892021 @default.
• W2075120289 crossrefType "journal-article" @default.
• W2075120289 hasAuthorship W2075120289A5025916093 @default.
• W2075120289 hasAuthorship W2075120289A5052810142 @default.
• W2075120289 hasAuthorship W2075120289A5091017979 @default.
• W2075120289 hasBestOaLocation W20751202892 @default.
• W2075120289 hasConcept C126322002 @default.
• W2075120289 hasConcept C127160389 @default.
• W2075120289 hasConcept C134018914 @default.
• W2075120289 hasConcept C170493617 @default.
• W2075120289 hasConcept C178790620 @default.
• W2075120289 hasConcept C185592680 @default.
• W2075120289 hasConcept C2776779347 @default.
• W2075120289 hasConcept C2777248517 @default.
• W2075120289 hasConcept C2777427919 @default.
• W2075120289 hasConcept C2780091579 @default.
• W2075120289 hasConcept C28406088 @default.
• W2075120289 hasConcept C41625074 @default.
• W2075120289 hasConcept C537181965 @default.
• W2075120289 hasConcept C55493867 @default.
• W2075120289 hasConcept C57947595 @default.
• W2075120289 hasConcept C71924100 @default.
• W2075120289 hasConcept C86803240 @default.
• W2075120289 hasConceptScore W2075120289C126322002 @default.
• W2075120289 hasConceptScore W2075120289C127160389 @default.
• W2075120289 hasConceptScore W2075120289C134018914 @default.
• W2075120289 hasConceptScore W2075120289C170493617 @default.
• W2075120289 hasConceptScore W2075120289C178790620 @default.
• W2075120289 hasConceptScore W2075120289C185592680 @default.
• W2075120289 hasConceptScore W2075120289C2776779347 @default.
• W2075120289 hasConceptScore W2075120289C2777248517 @default.
• W2075120289 hasConceptScore W2075120289C2777427919 @default.
• W2075120289 hasConceptScore W2075120289C2780091579 @default.
• W2075120289 hasConceptScore W2075120289C28406088 @default.
• W2075120289 hasConceptScore W2075120289C41625074 @default.
• W2075120289 hasConceptScore W2075120289C537181965 @default.
• W2075120289 hasConceptScore W2075120289C55493867 @default.
• W2075120289 hasConceptScore W2075120289C57947595 @default.
• W2075120289 hasConceptScore W2075120289C71924100 @default.
• W2075120289 hasConceptScore W2075120289C86803240 @default.
• W2075120289 hasIssue "15" @default.
• W2075120289 hasLocation W20751202891 @default.
• W2075120289 hasLocation W20751202892 @default.
• W2075120289 hasLocation W20751202893 @default.
• W2075120289 hasLocation W20751202894 @default.
• W2075120289 hasOpenAccess W2075120289 @default.
• W2075120289 hasPrimaryLocation W20751202891 @default.
• W2075120289 hasRelatedWork W1547565288 @default.
• W2075120289 hasRelatedWork W1999277911 @default.
• W2075120289 hasRelatedWork W2018093451 @default.
• W2075120289 hasRelatedWork W2066751242 @default.
• W2075120289 hasRelatedWork W2075120289 @default.

• next