Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075131034> ?p ?o ?g. }
- W2075131034 endingPage "116" @default.
- W2075131034 startingPage "101" @default.
- W2075131034 abstract "Summary: Ovarian cancer remains a challenging disease for which improved treatments are urgently needed. Most patients present with advanced disease that is highly responsive to surgery combined with platinum‐ and taxane‐based chemotherapy, with a state of minimal residual disease being achieved in many cases. However, chemotherapy‐resistant recurrent tumors typically appear within 1–5 years and are ultimately fatal. Recently, several groups have shown that ovarian tumors are often infiltrated by activated T cells at the time of diagnosis, and patients with dense infiltrates of CD3 + CD8 + T cells experience unexpectedly favorable progression‐free and overall survival. Other cell types in the immune infiltrate oppose anti‐tumor immunity, including CD4 + CD25 + FoxP3 + regulatory T cells, CD8 + regulatory T cells, macrophages, and dendritic cells. The composition of immune infiltrates is shaped by the expression of cytokines, chemokines, antigens, major histocompatibility complex molecules, and costimulatory molecules. The relationship between these various immunological factors is reviewed here with a strong emphasis on outcomes data so as to create a knowledge base that is well grounded in clinical reality. With improved understanding of the functional properties of natural CD8 + T‐cell responses to ovarian cancer, there is great potential to improve clinical outcomes by amplifying host immunity." @default.
- W2075131034 created "2016-06-24" @default.
- W2075131034 creator A5058837420 @default.
- W2075131034 date "2008-03-19" @default.
- W2075131034 modified "2023-10-17" @default.
- W2075131034 title "The impact of T‐cell immunity on ovarian cancer outcomes" @default.
- W2075131034 cites W1480357432 @default.
- W2075131034 cites W1481535764 @default.
- W2075131034 cites W1489727063 @default.
- W2075131034 cites W1506033553 @default.
- W2075131034 cites W1543091991 @default.
- W2075131034 cites W1550301398 @default.
- W2075131034 cites W1566226495 @default.
- W2075131034 cites W1580312675 @default.
- W2075131034 cites W1585672703 @default.
- W2075131034 cites W1600585219 @default.
- W2075131034 cites W1623963004 @default.
- W2075131034 cites W1927023482 @default.
- W2075131034 cites W1937488742 @default.
- W2075131034 cites W1947771442 @default.
- W2075131034 cites W1965778281 @default.
- W2075131034 cites W1966948292 @default.
- W2075131034 cites W1970080794 @default.
- W2075131034 cites W1971524116 @default.
- W2075131034 cites W1972250794 @default.
- W2075131034 cites W1975078287 @default.
- W2075131034 cites W1976002760 @default.
- W2075131034 cites W1976044621 @default.
- W2075131034 cites W1976220760 @default.
- W2075131034 cites W1976564360 @default.
- W2075131034 cites W1978005063 @default.
- W2075131034 cites W1979661110 @default.
- W2075131034 cites W1980920767 @default.
- W2075131034 cites W1982467804 @default.
- W2075131034 cites W1982785558 @default.
- W2075131034 cites W1984366825 @default.
- W2075131034 cites W1988685743 @default.
- W2075131034 cites W1989317719 @default.
- W2075131034 cites W1989814127 @default.
- W2075131034 cites W1990613023 @default.
- W2075131034 cites W1995005342 @default.
- W2075131034 cites W1995415079 @default.
- W2075131034 cites W1997339077 @default.
- W2075131034 cites W2000175691 @default.
- W2075131034 cites W2000776551 @default.
- W2075131034 cites W2002877066 @default.
- W2075131034 cites W2004240476 @default.
- W2075131034 cites W2006983673 @default.
- W2075131034 cites W2007722259 @default.
- W2075131034 cites W2007876410 @default.
- W2075131034 cites W2009648532 @default.
- W2075131034 cites W2012229186 @default.
- W2075131034 cites W2012416768 @default.
- W2075131034 cites W2012749338 @default.
- W2075131034 cites W2013244361 @default.
- W2075131034 cites W2013594457 @default.
- W2075131034 cites W2015466920 @default.
- W2075131034 cites W2016612145 @default.
- W2075131034 cites W2017965620 @default.
- W2075131034 cites W2022715332 @default.
- W2075131034 cites W2023291165 @default.
- W2075131034 cites W2026025784 @default.
- W2075131034 cites W2028000100 @default.
- W2075131034 cites W2029683448 @default.
- W2075131034 cites W2029743230 @default.
- W2075131034 cites W2036174104 @default.
- W2075131034 cites W2037338220 @default.
- W2075131034 cites W2042018916 @default.
- W2075131034 cites W2045831378 @default.
- W2075131034 cites W2048607324 @default.
- W2075131034 cites W2048810850 @default.
- W2075131034 cites W2048880738 @default.
- W2075131034 cites W2052445509 @default.
- W2075131034 cites W2053184982 @default.
- W2075131034 cites W2053353274 @default.
- W2075131034 cites W2055599144 @default.
- W2075131034 cites W2056433735 @default.
- W2075131034 cites W2057756943 @default.
- W2075131034 cites W2060164605 @default.
- W2075131034 cites W2060622134 @default.
- W2075131034 cites W2061206882 @default.
- W2075131034 cites W2064909516 @default.
- W2075131034 cites W2066727125 @default.
- W2075131034 cites W2067327438 @default.
- W2075131034 cites W2069892840 @default.
- W2075131034 cites W2070154027 @default.
- W2075131034 cites W2071185172 @default.
- W2075131034 cites W2071887194 @default.
- W2075131034 cites W2074383462 @default.
- W2075131034 cites W2076246074 @default.
- W2075131034 cites W2077765884 @default.
- W2075131034 cites W2078197336 @default.
- W2075131034 cites W2080006142 @default.
- W2075131034 cites W2081930825 @default.
- W2075131034 cites W2083571567 @default.
- W2075131034 cites W2083765379 @default.
- W2075131034 cites W2087801360 @default.
- W2075131034 cites W2087936235 @default.