FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075146633> ?p ?o ?g. }

• W2075146633 endingPage "776" @default.
• W2075146633 startingPage "767" @default.
• W2075146633 abstract "Reelin signaling is required for appropriate cell migration and ductal patterning during mammary gland morphogenesis. Dab1, an intracellular adaptor protein activated in response to reelin signaling, is expressed in the developing mammary bud and in luminal epithelial cells in the adult gland. Reelin protein is expressed in a complementary pattern, first in the epithelium overlying the mammary bud during embryogenesis and then in the myoepithelium and periductal stroma in the adult. Deletion in mouse of either reelin or Dab1 induced alterations in the development of the ductal network, including significant retardation in ductal elongation, decreased terminal branching, and thickening and disorganization of the luminal wall. At later stages, some mutant glands overcame these early delays, but went on to exhibit enlarged and chaotic ductal morphologies and decreased terminal branching: these phenotypes are suggestive of a role for reelin in spatial patterning or structural organization of the mammary epithelium. Isolated mammary epithelial cells exhibited decreased migration in response to exogenous reelin in vitro, a response that required Dab1. These observations highlight a role for reelin signaling in the directed migration of mammary epithelial cells driving ductal elongation into the mammary fat pad and provide the first evidence that reelin signaling may be crucial for regulating the migration and organization of non-neural tissues." @default.
• W2075146633 created "2016-06-24" @default.
• W2075146633 creator A5027558440 @default.
• W2075146633 creator A5034971972 @default.
• W2075146633 creator A5090527825 @default.
• W2075146633 date "2011-02-15" @default.
• W2075146633 modified "2023-10-16" @default.
• W2075146633 title "Disruption of reelin signaling alters mammary gland morphogenesis" @default.
• W2075146633 cites W1574303566 @default.
• W2075146633 cites W1667992367 @default.
• W2075146633 cites W1964332206 @default.
• W2075146633 cites W1968295677 @default.
• W2075146633 cites W1979440527 @default.
• W2075146633 cites W1979890518 @default.
• W2075146633 cites W1984957332 @default.
• W2075146633 cites W1988013635 @default.
• W2075146633 cites W1988168602 @default.
• W2075146633 cites W1991075591 @default.
• W2075146633 cites W1995447995 @default.
• W2075146633 cites W1996562234 @default.
• W2075146633 cites W1997387647 @default.
• W2075146633 cites W2009851817 @default.
• W2075146633 cites W2010040980 @default.
• W2075146633 cites W2013101182 @default.
• W2075146633 cites W2013774910 @default.
• W2075146633 cites W2014157399 @default.
• W2075146633 cites W2020880696 @default.
• W2075146633 cites W2021868064 @default.
• W2075146633 cites W2023669249 @default.
• W2075146633 cites W2032415900 @default.
• W2075146633 cites W2033822739 @default.
• W2075146633 cites W2039895922 @default.
• W2075146633 cites W2040407429 @default.
• W2075146633 cites W2045414448 @default.
• W2075146633 cites W2059797981 @default.
• W2075146633 cites W2066132043 @default.
• W2075146633 cites W2076566237 @default.
• W2075146633 cites W2088811751 @default.
• W2075146633 cites W2095032355 @default.
• W2075146633 cites W2116521814 @default.
• W2075146633 cites W2118059649 @default.
• W2075146633 cites W2122165646 @default.
• W2075146633 cites W2125496420 @default.
• W2075146633 cites W2135571525 @default.
• W2075146633 cites W2143927620 @default.
• W2075146633 cites W2162321314 @default.
• W2075146633 doi "https://doi.org/10.1242/dev.057588" @default.
• W2075146633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3026418" @default.
• W2075146633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21266412" @default.
• W2075146633 hasPublicationYear "2011" @default.
• W2075146633 type Work @default.
• W2075146633 sameAs 2075146633 @default.
• W2075146633 citedByCount "26" @default.
• W2075146633 countsByYear W20751466332012 @default.
• W2075146633 countsByYear W20751466332013 @default.
• W2075146633 countsByYear W20751466332014 @default.
• W2075146633 countsByYear W20751466332015 @default.
• W2075146633 countsByYear W20751466332016 @default.
• W2075146633 countsByYear W20751466332017 @default.
• W2075146633 countsByYear W20751466332019 @default.
• W2075146633 countsByYear W20751466332021 @default.
• W2075146633 countsByYear W20751466332023 @default.
• W2075146633 crossrefType "journal-article" @default.
• W2075146633 hasAuthorship W2075146633A5027558440 @default.
• W2075146633 hasAuthorship W2075146633A5034971972 @default.
• W2075146633 hasAuthorship W2075146633A5090527825 @default.
• W2075146633 hasBestOaLocation W20751466332 @default.
• W2075146633 hasConcept C104317684 @default.
• W2075146633 hasConcept C121608353 @default.
• W2075146633 hasConcept C140884156 @default.
• W2075146633 hasConcept C188209991 @default.
• W2075146633 hasConcept C189165786 @default.
• W2075146633 hasConcept C203014093 @default.
• W2075146633 hasConcept C204232928 @default.
• W2075146633 hasConcept C2778001805 @default.
• W2075146633 hasConcept C2778063154 @default.
• W2075146633 hasConcept C40692019 @default.
• W2075146633 hasConcept C530470458 @default.
• W2075146633 hasConcept C54355233 @default.
• W2075146633 hasConcept C62478195 @default.
• W2075146633 hasConcept C86803240 @default.
• W2075146633 hasConcept C95444343 @default.
• W2075146633 hasConceptScore W2075146633C104317684 @default.
• W2075146633 hasConceptScore W2075146633C121608353 @default.
• W2075146633 hasConceptScore W2075146633C140884156 @default.
• W2075146633 hasConceptScore W2075146633C188209991 @default.
• W2075146633 hasConceptScore W2075146633C189165786 @default.
• W2075146633 hasConceptScore W2075146633C203014093 @default.
• W2075146633 hasConceptScore W2075146633C204232928 @default.
• W2075146633 hasConceptScore W2075146633C2778001805 @default.
• W2075146633 hasConceptScore W2075146633C2778063154 @default.
• W2075146633 hasConceptScore W2075146633C40692019 @default.
• W2075146633 hasConceptScore W2075146633C530470458 @default.
• W2075146633 hasConceptScore W2075146633C54355233 @default.
• W2075146633 hasConceptScore W2075146633C62478195 @default.
• W2075146633 hasConceptScore W2075146633C86803240 @default.
• W2075146633 hasConceptScore W2075146633C95444343 @default.
• W2075146633 hasIssue "4" @default.

• next