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- W2075152175 abstract "We used cDNA arrays to investigate molecular aspects of the differentiation of an immortalized line of oligodendroglial progenitors, and of immunopan-purified primary cultures of oligodendroglial progenitors, to immature oligodendroglia. Developmental regulation of the proteolipid and 2-hydroxyacylsphingosine 1-galactosyltransferase genes was tighter in the primary than in the immortalized cells. Our data suggest that increased expression of genes encoding the following proteins are involved in oligodendroglial differentiation: Fyn, Erk, p85, G-alpha-12 guanine nucleotide binding, and transducin beta-2 signal transduction molecules; glial maturation factor; the proteasomal subunits C8 and C3; the proteasomal targeting molecule polyubiquitin; the cell cycle regulatory proteins Set, protein phosphatase 2A, and nuclear tyrosine phosphatase (PRL-1); and the high-affinity glutamate cotransporter EAAC-1." @default.
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- W2075152175 date "2000-02-01" @default.
- W2075152175 modified "2023-09-25" @default.
- W2075152175 title "Analysis of oligodendroglial differentiation using cDNA arrays" @default.
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- W2075152175 doi "https://doi.org/10.1002/(sici)1097-4547(20000201)59:3<430::aid-jnr18>3.0.co;2-7" @default.
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