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- W2075156716 abstract "Expression of the estrogen receptor α (ERα) gene is subject to complex regulation. To elucidate the mechanisms of this regulation, the genomic organization and the physiological role of the multiple 5′-untranslated regions (5′-UTRs) must be determined. Here, we investigated the expression and splicing patterns of the human ERα E isoforms. We identified two novel untranslated exons, N1 and N2, in the 5′-region of the human ERα gene and multiple E isoform mRNA variants generated by alternative usage of non-coding internal exons. Expression of the N1-containing variants was observed only in the human breast adenocarcinoma cell line, MCF7, while the N2-containing variants were expressed in the adult liver and MCF7 cells. We examined post-transcriptional regulation of the variant mRNAs using luciferase reporter assays and quantitative PCR. The insertion of untranslated internal exons into the 5′-UTRs of the E isoforms reduced their translation efficiency, but barely influenced mRNA turnover. Our results indicate that the genomic organization of the human ERα gene and the splicing profiles of the human ERα E isoforms are more complicated than previously reported. Furthermore, the 5′-UTRs of the E isoforms post-transcriptionally control human ERα expression mainly through translational repression." @default.
- W2075156716 created "2016-06-24" @default.
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- W2075156716 date "2013-01-01" @default.
- W2075156716 modified "2023-10-14" @default.
- W2075156716 title "Novel splicing events and post-transcriptional regulation of human estrogen receptor α E isoforms" @default.
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- W2075156716 doi "https://doi.org/10.1016/j.jsbmb.2012.09.027" @default.
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