FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075158118> ?p ?o ?g. }

• W2075158118 endingPage "1578" @default.
• W2075158118 startingPage "1567" @default.
• W2075158118 abstract "Recent studies have demonstrated that cannabinoid-1 (CB1) receptor blockade ameliorated inflammation, endothelial and/or cardiac dysfunction, and cell death in models of nephropathy, atherosclerosis and cardiomyopathy. However the role of CB1 receptor signalling in diabetic retinopathy remains unexplored. Using genetic deletion or pharmacological inhibition of the CB1 receptor with SR141716 (rimonabant) in a rodent model of diabetic retinopathy or in human primary retinal endothelial cells (HREC) exposed to high glucose, we explored the role of CB1 receptors in the pathogenesis of diabetic retinopathy. Diabetes was induced using streptozotocin in C57BL/6J Cb 1 (also known as Cnr1)+/+ and Cb 1 −/− mice aged 8 to 12 weeks. Samples from mice retina or HREC were used to determine: (1) apoptosis; (2) activity of nuclear factor kappa B, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), poly (ADP-ribose) polymerase and caspase-3; (3) content of 3-nitrotyrosine and reactive oxygen species; and (4) activation of p38/Jun N-terminal kinase/mitogen-activated protein kinase (MAPK). Deletion of CB1 receptor or treatment of diabetic mice with CB1 receptor antagonist SR141716 prevented retinal cell death. Treatment of diabetic mice or HREC cells exposed to high glucose with SR141716 attenuated the oxidative and nitrative stress, and reduced levels of nuclear factor κB, ICAM-1 and VCAM-1. In addition, SR141716 attenuated the diabetes- or high glucose-induced pro-apoptotic activation of MAPK and retinal vascular cell death. Activation of CB1 receptors may play an important role in the pathogenesis of diabetic retinopathy by facilitating MAPK activation, oxidative stress and inflammatory signalling. Conversely, CB1 receptor inhibition may be beneficial in the treatment of this devastating complication of diabetes." @default.
• W2075158118 created "2016-06-24" @default.
• W2075158118 creator A5026980318 @default.
• W2075158118 creator A5028080816 @default.
• W2075158118 creator A5042934677 @default.
• W2075158118 creator A5052876785 @default.
• W2075158118 creator A5066740889 @default.
• W2075158118 creator A5074185770 @default.
• W2075158118 creator A5081465188 @default.
• W2075158118 creator A5084119264 @default.
• W2075158118 date "2011-03-04" @default.
• W2075158118 modified "2023-10-17" @default.
• W2075158118 title "Cannabinoid 1 receptor activation contributes to vascular inflammation and cell death in a mouse model of diabetic retinopathy and a human retinal cell line" @default.
• W2075158118 cites W1567501285 @default.
• W2075158118 cites W1701529362 @default.
• W2075158118 cites W1964182457 @default.
• W2075158118 cites W1966234811 @default.
• W2075158118 cites W1968859345 @default.
• W2075158118 cites W1971955583 @default.
• W2075158118 cites W1980484722 @default.
• W2075158118 cites W1982329540 @default.
• W2075158118 cites W1982399892 @default.
• W2075158118 cites W1986434175 @default.
• W2075158118 cites W1987239083 @default.
• W2075158118 cites W1987760348 @default.
• W2075158118 cites W1993999238 @default.
• W2075158118 cites W2001276618 @default.
• W2075158118 cites W2009221618 @default.
• W2075158118 cites W2012633994 @default.
• W2075158118 cites W2016318917 @default.
• W2075158118 cites W2027688921 @default.
• W2075158118 cites W2033055869 @default.
• W2075158118 cites W2041130738 @default.
• W2075158118 cites W2052101688 @default.
• W2075158118 cites W2054655581 @default.
• W2075158118 cites W2064294492 @default.
• W2075158118 cites W2066613757 @default.
• W2075158118 cites W2066681847 @default.
• W2075158118 cites W2069004874 @default.
• W2075158118 cites W2077124174 @default.
• W2075158118 cites W2084655719 @default.
• W2075158118 cites W2093234681 @default.
• W2075158118 cites W2096102502 @default.
• W2075158118 cites W2098416362 @default.
• W2075158118 cites W2100694105 @default.
• W2075158118 cites W2103713988 @default.
• W2075158118 cites W2119826244 @default.
• W2075158118 cites W2120276758 @default.
• W2075158118 cites W2122352404 @default.
• W2075158118 cites W2122386753 @default.
• W2075158118 cites W2124466520 @default.
• W2075158118 cites W2125438637 @default.
• W2075158118 cites W2136608474 @default.
• W2075158118 cites W2139881033 @default.
• W2075158118 cites W2161887175 @default.
• W2075158118 cites W2164395140 @default.
• W2075158118 cites W2171845476 @default.
• W2075158118 cites W2249574602 @default.
• W2075158118 cites W39726490 @default.
• W2075158118 cites W4750530 @default.
• W2075158118 doi "https://doi.org/10.1007/s00125-011-2061-4" @default.
• W2075158118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3375271" @default.
• W2075158118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21373835" @default.
• W2075158118 hasPublicationYear "2011" @default.
• W2075158118 type Work @default.
• W2075158118 sameAs 2075158118 @default.
• W2075158118 citedByCount "65" @default.
• W2075158118 countsByYear W20751581182012 @default.
• W2075158118 countsByYear W20751581182013 @default.
• W2075158118 countsByYear W20751581182014 @default.
• W2075158118 countsByYear W20751581182015 @default.
• W2075158118 countsByYear W20751581182016 @default.
• W2075158118 countsByYear W20751581182017 @default.
• W2075158118 countsByYear W20751581182018 @default.
• W2075158118 countsByYear W20751581182019 @default.
• W2075158118 countsByYear W20751581182020 @default.
• W2075158118 countsByYear W20751581182021 @default.
• W2075158118 countsByYear W20751581182022 @default.
• W2075158118 countsByYear W20751581182023 @default.
• W2075158118 crossrefType "journal-article" @default.
• W2075158118 hasAuthorship W2075158118A5026980318 @default.
• W2075158118 hasAuthorship W2075158118A5028080816 @default.
• W2075158118 hasAuthorship W2075158118A5042934677 @default.
• W2075158118 hasAuthorship W2075158118A5052876785 @default.
• W2075158118 hasAuthorship W2075158118A5066740889 @default.
• W2075158118 hasAuthorship W2075158118A5074185770 @default.
• W2075158118 hasAuthorship W2075158118A5081465188 @default.
• W2075158118 hasAuthorship W2075158118A5084119264 @default.
• W2075158118 hasBestOaLocation W20751581181 @default.
• W2075158118 hasConcept C126322002 @default.
• W2075158118 hasConcept C134018914 @default.
• W2075158118 hasConcept C148001335 @default.
• W2075158118 hasConcept C170493617 @default.
• W2075158118 hasConcept C2776885963 @default.
• W2075158118 hasConcept C2778313320 @default.
• W2075158118 hasConcept C2779829184 @default.
• W2075158118 hasConcept C555293320 @default.
• W2075158118 hasConcept C71924100 @default.

• next