Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075161068> ?p ?o ?g. }
- W2075161068 endingPage "595" @default.
- W2075161068 startingPage "585" @default.
- W2075161068 abstract "Hemoglobin is the major protein in red blood cells and transports oxygen from the lungs to oxygen-demanding tissues, like the brain. Mechanisms that facilitate the uptake of oxygen in the vertebrate brain are unknown. In invertebrates, neuronal hemoglobin serves as intracellular storage molecule for oxygen. Here, we show by immunohistochemistry that hemoglobin is specifically expressed in neurons of the cortex, hippocampus, and cerebellum of the rodent brain, but not in astrocytes and oligodendrocytes. The neuronal hemoglobin distribution is distinct from the neuroglobin expression pattern on both cellular and subcellular levels. Probing for low oxygen levels in the tissue, we provide evidence that hemoglobin alpha-positive cells in direct neighborhood with hemoglobin alpha-negative cells display a better oxygenation than their neighbors and can be sharply distinguished from those. Neuronal hemoglobin expression is upregulated by injection or transgenic overexpression of erythropoietin and is accompanied by enhanced brain oxygenation under physiologic and hypoxic conditions. Thus we provide a novel mechanism for the neuroprotective actions of erythropoietin under ischemic-hypoxic conditions. We propose that neuronal hemoglobin expression is connected to facilitated oxygen uptake in neurons, and hemoglobin might serve as oxygen capacitator molecule." @default.
- W2075161068 created "2016-06-24" @default.
- W2075161068 creator A5003603275 @default.
- W2075161068 creator A5009032012 @default.
- W2075161068 creator A5017635489 @default.
- W2075161068 creator A5021153698 @default.
- W2075161068 creator A5027977201 @default.
- W2075161068 creator A5041579942 @default.
- W2075161068 creator A5048166262 @default.
- W2075161068 creator A5051205910 @default.
- W2075161068 creator A5069442019 @default.
- W2075161068 creator A5080635567 @default.
- W2075161068 creator A5083660340 @default.
- W2075161068 date "2008-12-31" @default.
- W2075161068 modified "2023-10-06" @default.
- W2075161068 title "Expression of Hemoglobin in Rodent Neurons" @default.
- W2075161068 cites W1653986885 @default.
- W2075161068 cites W174601502 @default.
- W2075161068 cites W1965075708 @default.
- W2075161068 cites W1974381392 @default.
- W2075161068 cites W1976869427 @default.
- W2075161068 cites W1978282308 @default.
- W2075161068 cites W1978726693 @default.
- W2075161068 cites W1980774547 @default.
- W2075161068 cites W1981746398 @default.
- W2075161068 cites W2003406245 @default.
- W2075161068 cites W2018921526 @default.
- W2075161068 cites W2022841473 @default.
- W2075161068 cites W2023534353 @default.
- W2075161068 cites W2030730293 @default.
- W2075161068 cites W2037114019 @default.
- W2075161068 cites W2041098348 @default.
- W2075161068 cites W2042189418 @default.
- W2075161068 cites W2042206208 @default.
- W2075161068 cites W2042386778 @default.
- W2075161068 cites W2059405876 @default.
- W2075161068 cites W2062603056 @default.
- W2075161068 cites W2080725398 @default.
- W2075161068 cites W2088364385 @default.
- W2075161068 cites W2089107920 @default.
- W2075161068 cites W2092958210 @default.
- W2075161068 cites W2094751995 @default.
- W2075161068 cites W2098004205 @default.
- W2075161068 cites W2099686361 @default.
- W2075161068 cites W2099802623 @default.
- W2075161068 cites W2100072314 @default.
- W2075161068 cites W2104445710 @default.
- W2075161068 cites W2111199238 @default.
- W2075161068 cites W2112418887 @default.
- W2075161068 cites W2113707590 @default.
- W2075161068 cites W2125229121 @default.
- W2075161068 cites W2127778297 @default.
- W2075161068 cites W2171296382 @default.
- W2075161068 cites W43446693 @default.
- W2075161068 doi "https://doi.org/10.1038/jcbfm.2008.152" @default.
- W2075161068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19116637" @default.
- W2075161068 hasPublicationYear "2008" @default.
- W2075161068 type Work @default.
- W2075161068 sameAs 2075161068 @default.
- W2075161068 citedByCount "122" @default.
- W2075161068 countsByYear W20751610682012 @default.
- W2075161068 countsByYear W20751610682013 @default.
- W2075161068 countsByYear W20751610682014 @default.
- W2075161068 countsByYear W20751610682015 @default.
- W2075161068 countsByYear W20751610682016 @default.
- W2075161068 countsByYear W20751610682017 @default.
- W2075161068 countsByYear W20751610682018 @default.
- W2075161068 countsByYear W20751610682019 @default.
- W2075161068 countsByYear W20751610682020 @default.
- W2075161068 countsByYear W20751610682021 @default.
- W2075161068 countsByYear W20751610682022 @default.
- W2075161068 countsByYear W20751610682023 @default.
- W2075161068 crossrefType "journal-article" @default.
- W2075161068 hasAuthorship W2075161068A5003603275 @default.
- W2075161068 hasAuthorship W2075161068A5009032012 @default.
- W2075161068 hasAuthorship W2075161068A5017635489 @default.
- W2075161068 hasAuthorship W2075161068A5021153698 @default.
- W2075161068 hasAuthorship W2075161068A5027977201 @default.
- W2075161068 hasAuthorship W2075161068A5041579942 @default.
- W2075161068 hasAuthorship W2075161068A5048166262 @default.
- W2075161068 hasAuthorship W2075161068A5051205910 @default.
- W2075161068 hasAuthorship W2075161068A5069442019 @default.
- W2075161068 hasAuthorship W2075161068A5080635567 @default.
- W2075161068 hasAuthorship W2075161068A5083660340 @default.
- W2075161068 hasConcept C125996951 @default.
- W2075161068 hasConcept C134018914 @default.
- W2075161068 hasConcept C169760540 @default.
- W2075161068 hasConcept C185592680 @default.
- W2075161068 hasConcept C25498285 @default.
- W2075161068 hasConcept C2776318716 @default.
- W2075161068 hasConcept C2778534260 @default.
- W2075161068 hasConcept C2778917026 @default.
- W2075161068 hasConcept C2781161787 @default.
- W2075161068 hasConcept C55493867 @default.
- W2075161068 hasConcept C86803240 @default.
- W2075161068 hasConcept C95444343 @default.
- W2075161068 hasConceptScore W2075161068C125996951 @default.
- W2075161068 hasConceptScore W2075161068C134018914 @default.