Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075178434> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2075178434 endingPage "402" @default.
- W2075178434 startingPage "395" @default.
- W2075178434 abstract "The Mtv-6 provirus has an incomplete genome, but retains a functional superantigen gene (sag) which directs the thymic deletion of CD4+ T cells expressing T cell receptors containing the V beta 3 or V beta 5 chains. To better understand the Mtv-6 superantigen, the structure and biological activity of the Mtv-6 provirus was analyzed. First, the complete nucleotide sequence was determined, and the mutation producing the subgenomic provirus was identified. Second, the nucleotide sequence of the 5' end of the sag gene transcript (including the splice junction) was determined by sequence analysis of a cDNA clone. Third, the superantigen activity of Mtv-6 was analyzed in mice carrying the Mtv-6 provirus isolated by selective breeding on a genetic background free of endogenous and exogenous mouse mammary tumor virus (MMTV). These studies demonstrate that (i) the Mtv-6 provirus contains a 6.2-kb deletion between two 12-bp direct repeats encompassing the central portion of the provirus but not affecting sag gene splicing or translation, (ii) the sag gene transcript has the structure predicted from previous S1 nuclease mapping studies, and (iii) the Mtv-6 superantigen can direct thymic deletion of target V beta 3+ and V beta 5+ T cells in the absence of gene products from full-length MMTV proviruses." @default.
- W2075178434 created "2016-06-24" @default.
- W2075178434 creator A5001769687 @default.
- W2075178434 creator A5016727533 @default.
- W2075178434 creator A5067902611 @default.
- W2075178434 date "1995-01-01" @default.
- W2075178434 modified "2023-10-17" @default.
- W2075178434 title "Structure and biological activity of the subgenomic Mtv-6 endogenous provirus" @default.
- W2075178434 cites W112611888 @default.
- W2075178434 cites W1486865225 @default.
- W2075178434 cites W1486906704 @default.
- W2075178434 cites W1531897207 @default.
- W2075178434 cites W1536082698 @default.
- W2075178434 cites W1540704453 @default.
- W2075178434 cites W1584742450 @default.
- W2075178434 cites W1632335268 @default.
- W2075178434 cites W1828216849 @default.
- W2075178434 cites W1903358508 @default.
- W2075178434 cites W1969831573 @default.
- W2075178434 cites W1982598903 @default.
- W2075178434 cites W1994529600 @default.
- W2075178434 cites W1995270566 @default.
- W2075178434 cites W1995490827 @default.
- W2075178434 cites W2002689833 @default.
- W2075178434 cites W2008437161 @default.
- W2075178434 cites W2010704087 @default.
- W2075178434 cites W2020460888 @default.
- W2075178434 cites W2026729878 @default.
- W2075178434 cites W2048399127 @default.
- W2075178434 cites W2060967265 @default.
- W2075178434 cites W2066963265 @default.
- W2075178434 cites W2072983673 @default.
- W2075178434 cites W2099841109 @default.
- W2075178434 cites W2104825278 @default.
- W2075178434 cites W2146148599 @default.
- W2075178434 cites W2146230183 @default.
- W2075178434 cites W4294216491 @default.
- W2075178434 cites W983702999 @default.
- W2075178434 doi "https://doi.org/10.1016/s0042-6822(95)80055-7" @default.
- W2075178434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7831795" @default.
- W2075178434 hasPublicationYear "1995" @default.
- W2075178434 type Work @default.
- W2075178434 sameAs 2075178434 @default.
- W2075178434 citedByCount "22" @default.
- W2075178434 countsByYear W20751784342013 @default.
- W2075178434 countsByYear W20751784342014 @default.
- W2075178434 countsByYear W20751784342022 @default.
- W2075178434 crossrefType "journal-article" @default.
- W2075178434 hasAuthorship W2075178434A5001769687 @default.
- W2075178434 hasAuthorship W2075178434A5016727533 @default.
- W2075178434 hasAuthorship W2075178434A5067902611 @default.
- W2075178434 hasConcept C102906071 @default.
- W2075178434 hasConcept C104317684 @default.
- W2075178434 hasConcept C141231307 @default.
- W2075178434 hasConcept C153911025 @default.
- W2075178434 hasConcept C159047783 @default.
- W2075178434 hasConcept C189819185 @default.
- W2075178434 hasConcept C2776090121 @default.
- W2075178434 hasConcept C36333154 @default.
- W2075178434 hasConcept C54355233 @default.
- W2075178434 hasConcept C86803240 @default.
- W2075178434 hasConcept C8891405 @default.
- W2075178434 hasConceptScore W2075178434C102906071 @default.
- W2075178434 hasConceptScore W2075178434C104317684 @default.
- W2075178434 hasConceptScore W2075178434C141231307 @default.
- W2075178434 hasConceptScore W2075178434C153911025 @default.
- W2075178434 hasConceptScore W2075178434C159047783 @default.
- W2075178434 hasConceptScore W2075178434C189819185 @default.
- W2075178434 hasConceptScore W2075178434C2776090121 @default.
- W2075178434 hasConceptScore W2075178434C36333154 @default.
- W2075178434 hasConceptScore W2075178434C54355233 @default.
- W2075178434 hasConceptScore W2075178434C86803240 @default.
- W2075178434 hasConceptScore W2075178434C8891405 @default.
- W2075178434 hasIssue "1" @default.
- W2075178434 hasLocation W20751784341 @default.
- W2075178434 hasLocation W20751784342 @default.
- W2075178434 hasOpenAccess W2075178434 @default.
- W2075178434 hasPrimaryLocation W20751784341 @default.
- W2075178434 hasRelatedWork W1592704104 @default.
- W2075178434 hasRelatedWork W2011091692 @default.
- W2075178434 hasRelatedWork W2036138560 @default.
- W2075178434 hasRelatedWork W2053876004 @default.
- W2075178434 hasRelatedWork W2057523692 @default.
- W2075178434 hasRelatedWork W2062120844 @default.
- W2075178434 hasRelatedWork W2075178434 @default.
- W2075178434 hasRelatedWork W2113072931 @default.
- W2075178434 hasRelatedWork W2266664725 @default.
- W2075178434 hasRelatedWork W2330413721 @default.
- W2075178434 hasVolume "206" @default.
- W2075178434 isParatext "false" @default.
- W2075178434 isRetracted "false" @default.
- W2075178434 magId "2075178434" @default.
- W2075178434 workType "article" @default.