Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075197298> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2075197298 endingPage "836" @default.
- W2075197298 startingPage "830" @default.
- W2075197298 abstract "Toxicity studies for intraperitoneal photodynamic therapy (IPPDT) were performed in Wag/RijA rats, using specially designed light delivery blocks for proper light distribution and light dosimetry. A recently developed photosensitizer mesotetrahydroxyphenylchlorin (mTHPC), excited at 652-nm wave-length, was compared with Photofrin (630 nm). Toxicity profiles for various sensitizer doses, light fluences and time intervals were investigated. A light fluence of 15 J.cm-2 delivered to the entire peritoneum 24 hr after 5 mg Photofrin per kg i.v. induced reversible impairment of intestinal, liver and kidney function. A dose of 0.2 mg mTHPC per kg i.v. followed by 6 J.cm-2 at 72 hr appeared to be equitoxic to the intestines; however, functional tests revealed little effect for this mTHPC-mediated IPPDT regime on liver or kidney. Histology demonstrated focal irreversible damage to the kidneys for both photosensitizers, not reflected in functional impairment. Light doses of 25 to 30 J.cm-2 at 24 hr after Photofrin or 8-12 J.cm-2, 72 hr after mTHPC caused lethal toxicity in the first 2 weeks due to intestinal damage. Higher light doses caused a shock syndrome and rhabdomyolysis resulting in death within 20 hr for both photosensitizers. In conclusion, maximum tolerable schedules for whole-abdomen IPPDT were defined for Photofrin and mTHPC. Both photosensitizers caused similar toxicity profiles depending on drug dose, light fluence and time interval." @default.
- W2075197298 created "2016-06-24" @default.
- W2075197298 creator A5015292429 @default.
- W2075197298 creator A5026812404 @default.
- W2075197298 creator A5040309636 @default.
- W2075197298 creator A5045970624 @default.
- W2075197298 creator A5051560890 @default.
- W2075197298 creator A5056079968 @default.
- W2075197298 creator A5056958833 @default.
- W2075197298 date "1994-12-15" @default.
- W2075197298 modified "2023-10-06" @default.
- W2075197298 title "Intraperitoneal photodynamic therapy in the rat: Comparison of toxicity profiles for photofrin and mTHPC" @default.
- W2075197298 cites W1771776794 @default.
- W2075197298 cites W1974712046 @default.
- W2075197298 cites W1974989935 @default.
- W2075197298 cites W1985757402 @default.
- W2075197298 cites W1992363953 @default.
- W2075197298 cites W1993366234 @default.
- W2075197298 cites W1996790872 @default.
- W2075197298 cites W2009553104 @default.
- W2075197298 cites W2028224679 @default.
- W2075197298 cites W2055646450 @default.
- W2075197298 cites W2059748188 @default.
- W2075197298 cites W2073288530 @default.
- W2075197298 cites W2078471390 @default.
- W2075197298 cites W2087138789 @default.
- W2075197298 cites W2107698420 @default.
- W2075197298 cites W2135957996 @default.
- W2075197298 cites W2162372312 @default.
- W2075197298 cites W2315404575 @default.
- W2075197298 cites W1989973072 @default.
- W2075197298 doi "https://doi.org/10.1002/ijc.2910590620" @default.
- W2075197298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7989125" @default.
- W2075197298 hasPublicationYear "1994" @default.
- W2075197298 type Work @default.
- W2075197298 sameAs 2075197298 @default.
- W2075197298 citedByCount "37" @default.
- W2075197298 countsByYear W20751972982015 @default.
- W2075197298 countsByYear W20751972982016 @default.
- W2075197298 countsByYear W20751972982017 @default.
- W2075197298 crossrefType "journal-article" @default.
- W2075197298 hasAuthorship W2075197298A5015292429 @default.
- W2075197298 hasAuthorship W2075197298A5026812404 @default.
- W2075197298 hasAuthorship W2075197298A5040309636 @default.
- W2075197298 hasAuthorship W2075197298A5045970624 @default.
- W2075197298 hasAuthorship W2075197298A5051560890 @default.
- W2075197298 hasAuthorship W2075197298A5056079968 @default.
- W2075197298 hasAuthorship W2075197298A5056958833 @default.
- W2075197298 hasConcept C116263406 @default.
- W2075197298 hasConcept C126322002 @default.
- W2075197298 hasConcept C178790620 @default.
- W2075197298 hasConcept C185592680 @default.
- W2075197298 hasConcept C202751555 @default.
- W2075197298 hasConcept C20639190 @default.
- W2075197298 hasConcept C2781323092 @default.
- W2075197298 hasConcept C2781469039 @default.
- W2075197298 hasConcept C29730261 @default.
- W2075197298 hasConcept C55493867 @default.
- W2075197298 hasConcept C71924100 @default.
- W2075197298 hasConcept C75473681 @default.
- W2075197298 hasConcept C98274493 @default.
- W2075197298 hasConceptScore W2075197298C116263406 @default.
- W2075197298 hasConceptScore W2075197298C126322002 @default.
- W2075197298 hasConceptScore W2075197298C178790620 @default.
- W2075197298 hasConceptScore W2075197298C185592680 @default.
- W2075197298 hasConceptScore W2075197298C202751555 @default.
- W2075197298 hasConceptScore W2075197298C20639190 @default.
- W2075197298 hasConceptScore W2075197298C2781323092 @default.
- W2075197298 hasConceptScore W2075197298C2781469039 @default.
- W2075197298 hasConceptScore W2075197298C29730261 @default.
- W2075197298 hasConceptScore W2075197298C55493867 @default.
- W2075197298 hasConceptScore W2075197298C71924100 @default.
- W2075197298 hasConceptScore W2075197298C75473681 @default.
- W2075197298 hasConceptScore W2075197298C98274493 @default.
- W2075197298 hasIssue "6" @default.
- W2075197298 hasLocation W20751972981 @default.
- W2075197298 hasLocation W20751972982 @default.
- W2075197298 hasOpenAccess W2075197298 @default.
- W2075197298 hasPrimaryLocation W20751972981 @default.
- W2075197298 hasRelatedWork W1973711322 @default.
- W2075197298 hasRelatedWork W2256492013 @default.
- W2075197298 hasRelatedWork W2361848027 @default.
- W2075197298 hasRelatedWork W2361967496 @default.
- W2075197298 hasRelatedWork W2753164976 @default.
- W2075197298 hasRelatedWork W3029655042 @default.
- W2075197298 hasRelatedWork W3158206585 @default.
- W2075197298 hasRelatedWork W4234956294 @default.
- W2075197298 hasRelatedWork W4247044552 @default.
- W2075197298 hasRelatedWork W4288988555 @default.
- W2075197298 hasVolume "59" @default.
- W2075197298 isParatext "false" @default.
- W2075197298 isRetracted "false" @default.
- W2075197298 magId "2075197298" @default.
- W2075197298 workType "article" @default.