FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075198451> ?p ?o ?g. }

• W2075198451 endingPage "270" @default.
• W2075198451 startingPage "255" @default.
• W2075198451 abstract "Transcription of the rabbit alpha-globin gene begins primarily at the cap site, although some upstream start sites are also observed. Analysis by RNA polymerase run-on assays in nuclei shows that transcription continues at a high level past the polyadenylation site, after which the polymerase density actually increases in a region of about 400 nucleotides, followed by a gradual decline over the 700 nucleotides. These features are also observed in the transcription unit of the rabbit beta-globin gene. The region with the unexpectedly high nascent RNA hybridization signal in the 3' flank contains a conserved sequence, KGCAGCWGGR (K = G or T, W = A or T, R = A or G), followed by an inverted repeat. The inverted repeat (perhaps with the conserved sequence) may be a pause site for RNA polymerase II, thus accounting for the increase in polymerase density. This sequence and inverted repeat are found in the 3' flank of several globin genes and the simian virus 40 (SV40) early genes, as well as in the regions implicated in pausing or termination of transcription of eight different genes. Deletion of the conserved sequence and inverted repeat from the 3' flank of the SV40 early region causes a small increase in the levels of transcription downstream from this site. Replacement with the conserved sequence and inverted repeat from the rabbit alpha-globin gene causes an accumulation of polymerases, supporting the hypothesis that polymerases pause at this site. This proposed pause site may affect the efficiency of termination at some sites further downstream, perhaps by loss of a processivity factor." @default.
• W2075198451 created "2016-06-24" @default.
• W2075198451 creator A5016381482 @default.
• W2075198451 creator A5036074664 @default.
• W2075198451 creator A5070207085 @default.
• W2075198451 date "1991-07-01" @default.
• W2075198451 modified "2023-09-25" @default.
• W2075198451 title "An apparent pause site in the transcription unit of the rabbit α-globin gene" @default.
• W2075198451 cites W1427409664 @default.
• W2075198451 cites W1485838626 @default.
• W2075198451 cites W1490953839 @default.
• W2075198451 cites W1501264308 @default.
• W2075198451 cites W1508975697 @default.
• W2075198451 cites W1515565736 @default.
• W2075198451 cites W1536333573 @default.
• W2075198451 cites W1594040544 @default.
• W2075198451 cites W1601687245 @default.
• W2075198451 cites W1605780295 @default.
• W2075198451 cites W1833930439 @default.
• W2075198451 cites W187132245 @default.
• W2075198451 cites W1955369670 @default.
• W2075198451 cites W1967737680 @default.
• W2075198451 cites W1974207075 @default.
• W2075198451 cites W1981777358 @default.
• W2075198451 cites W1995391727 @default.
• W2075198451 cites W1996164869 @default.
• W2075198451 cites W1998162329 @default.
• W2075198451 cites W2009310436 @default.
• W2075198451 cites W2023437882 @default.
• W2075198451 cites W2025627326 @default.
• W2075198451 cites W2027955922 @default.
• W2075198451 cites W2036903205 @default.
• W2075198451 cites W2037771997 @default.
• W2075198451 cites W2037852650 @default.
• W2075198451 cites W2040302336 @default.
• W2075198451 cites W2044512405 @default.
• W2075198451 cites W2050797066 @default.
• W2075198451 cites W2052437011 @default.
• W2075198451 cites W2057275708 @default.
• W2075198451 cites W2061320680 @default.
• W2075198451 cites W2071202800 @default.
• W2075198451 cites W2072346297 @default.
• W2075198451 cites W2072467553 @default.
• W2075198451 cites W2075307129 @default.
• W2075198451 cites W2079337115 @default.
• W2075198451 cites W2079543136 @default.
• W2075198451 cites W2086584161 @default.
• W2075198451 cites W2100726754 @default.
• W2075198451 cites W2103099401 @default.
• W2075198451 cites W2111954586 @default.
• W2075198451 cites W2138762386 @default.
• W2075198451 cites W2140714358 @default.
• W2075198451 cites W2143488845 @default.
• W2075198451 cites W2144206181 @default.
• W2075198451 cites W2145059527 @default.
• W2075198451 cites W2157589212 @default.
• W2075198451 cites W2164193506 @default.
• W2075198451 cites W2180891129 @default.
• W2075198451 cites W4233003623 @default.
• W2075198451 cites W4238062370 @default.
• W2075198451 cites W4256445429 @default.
• W2075198451 cites W91137656 @default.
• W2075198451 doi "https://doi.org/10.1016/0022-2836(91)90011-t" @default.
• W2075198451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1856860" @default.
• W2075198451 hasPublicationYear "1991" @default.
• W2075198451 type Work @default.
• W2075198451 sameAs 2075198451 @default.
• W2075198451 citedByCount "13" @default.
• W2075198451 countsByYear W20751984512012 @default.
• W2075198451 crossrefType "journal-article" @default.
• W2075198451 hasAuthorship W2075198451A5016381482 @default.
• W2075198451 hasAuthorship W2075198451A5036074664 @default.
• W2075198451 hasAuthorship W2075198451A5070207085 @default.
• W2075198451 hasConcept C101762097 @default.
• W2075198451 hasConcept C104317684 @default.
• W2075198451 hasConcept C138885662 @default.
• W2075198451 hasConcept C142575336 @default.
• W2075198451 hasConcept C150194340 @default.
• W2075198451 hasConcept C153911025 @default.
• W2075198451 hasConcept C179926584 @default.
• W2075198451 hasConcept C2776449523 @default.
• W2075198451 hasConcept C41895202 @default.
• W2075198451 hasConcept C51807208 @default.
• W2075198451 hasConcept C54355233 @default.
• W2075198451 hasConcept C64350747 @default.
• W2075198451 hasConcept C67705224 @default.
• W2075198451 hasConcept C82381507 @default.
• W2075198451 hasConcept C86803240 @default.
• W2075198451 hasConceptScore W2075198451C101762097 @default.
• W2075198451 hasConceptScore W2075198451C104317684 @default.
• W2075198451 hasConceptScore W2075198451C138885662 @default.
• W2075198451 hasConceptScore W2075198451C142575336 @default.
• W2075198451 hasConceptScore W2075198451C150194340 @default.
• W2075198451 hasConceptScore W2075198451C153911025 @default.
• W2075198451 hasConceptScore W2075198451C179926584 @default.
• W2075198451 hasConceptScore W2075198451C2776449523 @default.
• W2075198451 hasConceptScore W2075198451C41895202 @default.
• W2075198451 hasConceptScore W2075198451C51807208 @default.

• next