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• W2075200777 abstract "BAR proteins are involved in a variety of membrane remodeling events but how they can mold membranes into different shapes remains poorly understood. Using electron paramagnetic resonance, we find that vesicle binding of the N-BAR protein amphiphysin is predominantly mediated by the shallow insertion of amphipathic N-terminal helices. In contrast, the interaction with tubes involves deeply inserted N-terminal helices together with the concave surface of the BAR domain, which acts as a scaffold. Combined with the observed concentration dependence of tubulation and BAR domain scaffolding, the data indicate that initial membrane deformations and vesicle binding are mediated by insertion of amphipathic helical wedges, while tubulation requires high protein densities at which oligomeric BAR domain scaffolds form. In addition, we identify a pocket of residues on the concave surface of the BAR domain that insert deeply into tube membrane. Interestingly, this pocket harbors a number of disease mutants in the homologous amphiphysin 2." @default.
• W2075200777 created "2016-06-24" @default.
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• W2075200777 date "2015-05-01" @default.
• W2075200777 modified "2023-10-17" @default.
• W2075200777 title "Tubulation by Amphiphysin Requires Concentration-Dependent Switching from Wedging to Scaffolding" @default.
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• W2075200777 doi "https://doi.org/10.1016/j.str.2015.02.014" @default.
• W2075200777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4437528" @default.
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