FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075201088> ?p ?o ?g. }

• W2075201088 endingPage "e40287" @default.
• W2075201088 startingPage "e40287" @default.
• W2075201088 abstract "The β-amyloid precursor protein (APP), which is a key player in Alzheimer's disease, was recently reported to possess an Fe(II) binding site within its E2 domain which exhibits ferroxidase activity [Duce et al. 2010, Cell 142: 857]. The putative ligands of this site were compared to those in the ferroxidase site of ferritin. The activity was indirectly measured using transferrin, which scavenges the Fe(III) product of the reaction. A 22-residue synthetic peptide, named FD1, with the putative ferroxidase site of APP, and the E2 domain of APP were each reported to exhibit 40% of the ferroxidase activity of APP and of ceruloplasmin. It was also claimed that the ferroxidase activity of APP is inhibited by Zn(II) just as in ferritin. We measured the ferroxidase activity indirectly (i) by the incorporation of the Fe(III) product of the ferroxidase reaction into transferrin and directly (ii) by monitoring consumption of the substrate molecular oxygen. The results with the FD1 peptide were compared to the established ferroxidase activities of human H-chain ferritin and of ceruloplasmin. For FD1 we observed no activity above the background of non-enzymatic Fe(II) oxidation by molecular oxygen. Zn(II) binds to transferrin and diminishes its Fe(III) incorporation capacity and rate but it does not specifically bind to a putative ferroxidase site of FD1. Based on these results, and on comparison of the putative ligands of the ferroxidase site of APP with those of ferritin, we conclude that the previously reported results for ferroxidase activity of FD1 and – by implication – of APP should be re-evaluated." @default.
• W2075201088 created "2016-06-24" @default.
• W2075201088 creator A5006295332 @default.
• W2075201088 creator A5008826703 @default.
• W2075201088 creator A5016406473 @default.
• W2075201088 date "2012-08-14" @default.
• W2075201088 modified "2023-10-12" @default.
• W2075201088 title "A Synthetic Peptide with the Putative Iron Binding Motif of Amyloid Precursor Protein (APP) Does Not Catalytically Oxidize Iron" @default.
• W2075201088 cites W1508143080 @default.
• W2075201088 cites W1520189306 @default.
• W2075201088 cites W1556929642 @default.
• W2075201088 cites W1571036104 @default.
• W2075201088 cites W1572699553 @default.
• W2075201088 cites W1580121000 @default.
• W2075201088 cites W1860801498 @default.
• W2075201088 cites W1933062072 @default.
• W2075201088 cites W1968711656 @default.
• W2075201088 cites W1969061171 @default.
• W2075201088 cites W1980476680 @default.
• W2075201088 cites W1980964234 @default.
• W2075201088 cites W1983830973 @default.
• W2075201088 cites W1987133102 @default.
• W2075201088 cites W1987399454 @default.
• W2075201088 cites W1994235379 @default.
• W2075201088 cites W2012671084 @default.
• W2075201088 cites W2015583845 @default.
• W2075201088 cites W2018333394 @default.
• W2075201088 cites W2018378808 @default.
• W2075201088 cites W2023965625 @default.
• W2075201088 cites W2030249003 @default.
• W2075201088 cites W2030951143 @default.
• W2075201088 cites W2043351987 @default.
• W2075201088 cites W2046943766 @default.
• W2075201088 cites W2047172988 @default.
• W2075201088 cites W2069696961 @default.
• W2075201088 cites W2079283592 @default.
• W2075201088 cites W2079400095 @default.
• W2075201088 cites W2080733302 @default.
• W2075201088 cites W2087244548 @default.
• W2075201088 cites W2090148249 @default.
• W2075201088 cites W2109193231 @default.
• W2075201088 cites W2129085204 @default.
• W2075201088 cites W2145990795 @default.
• W2075201088 cites W2160421126 @default.
• W2075201088 cites W2163785699 @default.
• W2075201088 cites W2166698408 @default.
• W2075201088 cites W274005068 @default.
• W2075201088 cites W409581938 @default.
• W2075201088 cites W95595901 @default.
• W2075201088 doi "https://doi.org/10.1371/journal.pone.0040287" @default.
• W2075201088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3419245" @default.
• W2075201088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22916096" @default.
• W2075201088 hasPublicationYear "2012" @default.
• W2075201088 type Work @default.
• W2075201088 sameAs 2075201088 @default.
• W2075201088 citedByCount "25" @default.
• W2075201088 countsByYear W20752010882013 @default.
• W2075201088 countsByYear W20752010882014 @default.
• W2075201088 countsByYear W20752010882015 @default.
• W2075201088 countsByYear W20752010882016 @default.
• W2075201088 countsByYear W20752010882017 @default.
• W2075201088 countsByYear W20752010882021 @default.
• W2075201088 countsByYear W20752010882022 @default.
• W2075201088 countsByYear W20752010882023 @default.
• W2075201088 crossrefType "journal-article" @default.
• W2075201088 hasAuthorship W2075201088A5006295332 @default.
• W2075201088 hasAuthorship W2075201088A5008826703 @default.
• W2075201088 hasAuthorship W2075201088A5016406473 @default.
• W2075201088 hasBestOaLocation W20752010881 @default.
• W2075201088 hasConcept C181199279 @default.
• W2075201088 hasConcept C185592680 @default.
• W2075201088 hasConcept C22814914 @default.
• W2075201088 hasConcept C2778319317 @default.
• W2075201088 hasConcept C2779281246 @default.
• W2075201088 hasConcept C28452662 @default.
• W2075201088 hasConcept C41183919 @default.
• W2075201088 hasConcept C55493867 @default.
• W2075201088 hasConceptScore W2075201088C181199279 @default.
• W2075201088 hasConceptScore W2075201088C185592680 @default.
• W2075201088 hasConceptScore W2075201088C22814914 @default.
• W2075201088 hasConceptScore W2075201088C2778319317 @default.
• W2075201088 hasConceptScore W2075201088C2779281246 @default.
• W2075201088 hasConceptScore W2075201088C28452662 @default.
• W2075201088 hasConceptScore W2075201088C41183919 @default.
• W2075201088 hasConceptScore W2075201088C55493867 @default.
• W2075201088 hasIssue "8" @default.
• W2075201088 hasLocation W20752010881 @default.
• W2075201088 hasLocation W20752010882 @default.
• W2075201088 hasLocation W20752010883 @default.
• W2075201088 hasLocation W20752010884 @default.
• W2075201088 hasLocation W20752010885 @default.
• W2075201088 hasOpenAccess W2075201088 @default.
• W2075201088 hasPrimaryLocation W20752010881 @default.
• W2075201088 hasRelatedWork W1974646679 @default.
• W2075201088 hasRelatedWork W1976734959 @default.
• W2075201088 hasRelatedWork W2027647721 @default.
• W2075201088 hasRelatedWork W2063240950 @default.
• W2075201088 hasRelatedWork W2072419022 @default.

• next