FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075224242> ?p ?o ?g. }

• W2075224242 endingPage "1131" @default.
• W2075224242 startingPage "1127" @default.
• W2075224242 abstract "It is known that LINE-1 (long interspersed element-1) retrotransposons can move throughout the genomes of adult rat neural progenitor cells (NPCs) in vitro and in the mouse brain. Now it is shown that NPCs isolated from human fetal brain and derived from human embryonic stem cells also support the retrotransposition of engineered human LINE-1s in vitro. Interestingly, there is an increase in the copy number of endogenous LINE-1s in the hippocampus and elsewhere in adult human brains when compared to the copy number of endogenous LINE-1s in heart or liver genomic DNA from the same individual. This suggests that LINE-1 retrotransposition events may contribute to individual somatic mosaicism and heterogeneity of gene expression in the brain. Long interspersed element 1 (LINE-1 or L1) retrotransposons have been shown to move throughout the genomes of adult rat neural progenitor cells (NPCs) in vitro and in the mouse brain. Here, NPCs isolated from human fetal brain and derived from human embryonic stem cells are shown to support the retrotransposition of engineered human L1s in vitro, which could contribute to individual somatic mosaicism. Long interspersed element 1 (LINE-1 or L1) retrotransposons have markedly affected the human genome. L1s must retrotranspose in the germ line or during early development to ensure their evolutionary success, yet the extent to which this process affects somatic cells is poorly understood. We previously demonstrated that engineered human L1s can retrotranspose in adult rat hippocampus progenitor cells in vitro and in the mouse brain in vivo1. Here we demonstrate that neural progenitor cells isolated from human fetal brain and derived from human embryonic stem cells support the retrotransposition of engineered human L1s in vitro. Furthermore, we developed a quantitative multiplex polymerase chain reaction that detected an increase in the copy number of endogenous L1s in the hippocampus, and in several regions of adult human brains, when compared to the copy number of endogenous L1s in heart or liver genomic DNAs from the same donor. These data suggest that de novo L1 retrotransposition events may occur in the human brain and, in principle, have the potential to contribute to individual somatic mosaicism." @default.
• W2075224242 created "2016-06-24" @default.
• W2075224242 creator A5000937435 @default.
• W2075224242 creator A5016025349 @default.
• W2075224242 creator A5018885545 @default.
• W2075224242 creator A5019524405 @default.
• W2075224242 creator A5047646558 @default.
• W2075224242 creator A5060400275 @default.
• W2075224242 creator A5063982721 @default.
• W2075224242 creator A5072968010 @default.
• W2075224242 creator A5073070597 @default.
• W2075224242 creator A5082310752 @default.
• W2075224242 date "2009-08-01" @default.
• W2075224242 modified "2023-10-17" @default.
• W2075224242 title "L1 retrotransposition in human neural progenitor cells" @default.
• W2075224242 cites W1536915394 @default.
• W2075224242 cites W1971047655 @default.
• W2075224242 cites W1998154426 @default.
• W2075224242 cites W1999355295 @default.
• W2075224242 cites W2012537642 @default.
• W2075224242 cites W2028998497 @default.
• W2075224242 cites W2033284482 @default.
• W2075224242 cites W2036627966 @default.
• W2075224242 cites W2064629259 @default.
• W2075224242 cites W2065737043 @default.
• W2075224242 cites W2077053535 @default.
• W2075224242 cites W2083441571 @default.
• W2075224242 cites W2084652820 @default.
• W2075224242 cites W2086943348 @default.
• W2075224242 cites W2091279754 @default.
• W2075224242 cites W2104073505 @default.
• W2075224242 cites W2106551806 @default.
• W2075224242 cites W2113973815 @default.
• W2075224242 cites W2118155162 @default.
• W2075224242 cites W2119742125 @default.
• W2075224242 cites W2120034162 @default.
• W2075224242 cites W2125512488 @default.
• W2075224242 cites W2144121185 @default.
• W2075224242 cites W2150649207 @default.
• W2075224242 cites W2155264063 @default.
• W2075224242 cites W2162146849 @default.
• W2075224242 cites W777859302 @default.
• W2075224242 doi "https://doi.org/10.1038/nature08248" @default.
• W2075224242 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2909034" @default.
• W2075224242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19657334" @default.
• W2075224242 hasPublicationYear "2009" @default.
• W2075224242 type Work @default.
• W2075224242 sameAs 2075224242 @default.
• W2075224242 citedByCount "717" @default.
• W2075224242 countsByYear W20752242422012 @default.
• W2075224242 countsByYear W20752242422013 @default.
• W2075224242 countsByYear W20752242422014 @default.
• W2075224242 countsByYear W20752242422015 @default.
• W2075224242 countsByYear W20752242422016 @default.
• W2075224242 countsByYear W20752242422017 @default.
• W2075224242 countsByYear W20752242422018 @default.
• W2075224242 countsByYear W20752242422019 @default.
• W2075224242 countsByYear W20752242422020 @default.
• W2075224242 countsByYear W20752242422021 @default.
• W2075224242 countsByYear W20752242422022 @default.
• W2075224242 countsByYear W20752242422023 @default.
• W2075224242 crossrefType "journal-article" @default.
• W2075224242 hasAuthorship W2075224242A5000937435 @default.
• W2075224242 hasAuthorship W2075224242A5016025349 @default.
• W2075224242 hasAuthorship W2075224242A5018885545 @default.
• W2075224242 hasAuthorship W2075224242A5019524405 @default.
• W2075224242 hasAuthorship W2075224242A5047646558 @default.
• W2075224242 hasAuthorship W2075224242A5060400275 @default.
• W2075224242 hasAuthorship W2075224242A5063982721 @default.
• W2075224242 hasAuthorship W2075224242A5072968010 @default.
• W2075224242 hasAuthorship W2075224242A5073070597 @default.
• W2075224242 hasAuthorship W2075224242A5082310752 @default.
• W2075224242 hasBestOaLocation W20752242422 @default.
• W2075224242 hasConcept C104317684 @default.
• W2075224242 hasConcept C134305767 @default.
• W2075224242 hasConcept C136834591 @default.
• W2075224242 hasConcept C141231307 @default.
• W2075224242 hasConcept C145103041 @default.
• W2075224242 hasConcept C169760540 @default.
• W2075224242 hasConcept C197077220 @default.
• W2075224242 hasConcept C201750760 @default.
• W2075224242 hasConcept C202751555 @default.
• W2075224242 hasConcept C2777670902 @default.
• W2075224242 hasConcept C28328180 @default.
• W2075224242 hasConcept C4918238 @default.
• W2075224242 hasConcept C54355233 @default.
• W2075224242 hasConcept C7029365 @default.
• W2075224242 hasConcept C86803240 @default.
• W2075224242 hasConcept C95444343 @default.
• W2075224242 hasConceptScore W2075224242C104317684 @default.
• W2075224242 hasConceptScore W2075224242C134305767 @default.
• W2075224242 hasConceptScore W2075224242C136834591 @default.
• W2075224242 hasConceptScore W2075224242C141231307 @default.
• W2075224242 hasConceptScore W2075224242C145103041 @default.
• W2075224242 hasConceptScore W2075224242C169760540 @default.
• W2075224242 hasConceptScore W2075224242C197077220 @default.
• W2075224242 hasConceptScore W2075224242C201750760 @default.
• W2075224242 hasConceptScore W2075224242C202751555 @default.

• next