Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075230979> ?p ?o ?g. }
- W2075230979 endingPage "304" @default.
- W2075230979 startingPage "291" @default.
- W2075230979 abstract "Similar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that support growth and regeneration. How the niche regulates intestinal stem cell activity in both mammals and flies is not well understood. Here, we show that the conserved germinal center protein kinase Misshapen restricts intestinal stem cell division by repressing the expression of the JAK-STAT pathway ligand Upd3 in differentiating enteroblasts. Misshapen, a distant relative to the prototypic Warts activating kinase Hippo, interacts with and activates Warts to negatively regulate the activity of Yorkie and the expression of Upd3. The mammalian Misshapen homolog MAP4K4 similarly interacts with LATS (Warts homolog) and promotes inhibition of YAP (Yorkie homolog). Together, this work reveals that the Misshapen-Warts-Yorkie pathway acts in enteroblasts to control niche signaling to intestinal stem cells. These findings also provide a model in which to study requirements for MAP4K4-related kinases in MST1/2-independent regulation of LATS and YAP." @default.
- W2075230979 created "2016-06-24" @default.
- W2075230979 creator A5016679205 @default.
- W2075230979 creator A5020557933 @default.
- W2075230979 creator A5020746135 @default.
- W2075230979 creator A5025838174 @default.
- W2075230979 creator A5029871478 @default.
- W2075230979 creator A5030750875 @default.
- W2075230979 creator A5038071740 @default.
- W2075230979 creator A5039869472 @default.
- W2075230979 creator A5046252184 @default.
- W2075230979 creator A5051842618 @default.
- W2075230979 creator A5057505029 @default.
- W2075230979 creator A5060664398 @default.
- W2075230979 creator A5066556367 @default.
- W2075230979 creator A5067417733 @default.
- W2075230979 creator A5078079165 @default.
- W2075230979 creator A5079252087 @default.
- W2075230979 creator A5085687728 @default.
- W2075230979 date "2014-11-01" @default.
- W2075230979 modified "2023-10-18" @default.
- W2075230979 title "The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila" @default.
- W2075230979 cites W1466046862 @default.
- W2075230979 cites W1782202106 @default.
- W2075230979 cites W1912100238 @default.
- W2075230979 cites W1963587413 @default.
- W2075230979 cites W1963927300 @default.
- W2075230979 cites W1964684127 @default.
- W2075230979 cites W1968112233 @default.
- W2075230979 cites W1968814136 @default.
- W2075230979 cites W1972693900 @default.
- W2075230979 cites W1972911812 @default.
- W2075230979 cites W1973394316 @default.
- W2075230979 cites W1982603620 @default.
- W2075230979 cites W1985234259 @default.
- W2075230979 cites W1986932941 @default.
- W2075230979 cites W1991906900 @default.
- W2075230979 cites W1993058424 @default.
- W2075230979 cites W1994216131 @default.
- W2075230979 cites W1999282770 @default.
- W2075230979 cites W2003299661 @default.
- W2075230979 cites W2012553335 @default.
- W2075230979 cites W2013123192 @default.
- W2075230979 cites W2015909273 @default.
- W2075230979 cites W2017218715 @default.
- W2075230979 cites W2017828716 @default.
- W2075230979 cites W2019621646 @default.
- W2075230979 cites W2028133785 @default.
- W2075230979 cites W2030791386 @default.
- W2075230979 cites W2031217639 @default.
- W2075230979 cites W2033360354 @default.
- W2075230979 cites W2035151165 @default.
- W2075230979 cites W2037598426 @default.
- W2075230979 cites W2044897140 @default.
- W2075230979 cites W2046319746 @default.
- W2075230979 cites W2046985565 @default.
- W2075230979 cites W2051719116 @default.
- W2075230979 cites W2051909115 @default.
- W2075230979 cites W2054636918 @default.
- W2075230979 cites W2060558228 @default.
- W2075230979 cites W2061058076 @default.
- W2075230979 cites W2065653828 @default.
- W2075230979 cites W2070386387 @default.
- W2075230979 cites W2073594767 @default.
- W2075230979 cites W2073609428 @default.
- W2075230979 cites W2074872681 @default.
- W2075230979 cites W2076912393 @default.
- W2075230979 cites W2078027095 @default.
- W2075230979 cites W2079657320 @default.
- W2075230979 cites W2084745919 @default.
- W2075230979 cites W2088702684 @default.
- W2075230979 cites W2091883691 @default.
- W2075230979 cites W2097798460 @default.
- W2075230979 cites W2098972116 @default.
- W2075230979 cites W2099991247 @default.
- W2075230979 cites W2106918615 @default.
- W2075230979 cites W2109838283 @default.
- W2075230979 cites W2112933956 @default.
- W2075230979 cites W2115170590 @default.
- W2075230979 cites W2116233619 @default.
- W2075230979 cites W2116691044 @default.
- W2075230979 cites W2119021294 @default.
- W2075230979 cites W2120525124 @default.
- W2075230979 cites W2127539789 @default.
- W2075230979 cites W2129133276 @default.
- W2075230979 cites W2132605861 @default.
- W2075230979 cites W2135279653 @default.
- W2075230979 cites W2139463164 @default.
- W2075230979 cites W2142018200 @default.
- W2075230979 cites W2142360030 @default.
- W2075230979 cites W2152773922 @default.
- W2075230979 cites W2155111434 @default.
- W2075230979 cites W2162439237 @default.
- W2075230979 cites W2164874402 @default.
- W2075230979 cites W2165943251 @default.
- W2075230979 cites W2167247764 @default.
- W2075230979 doi "https://doi.org/10.1016/j.devcel.2014.09.012" @default.
- W2075230979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4254555" @default.