FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075259252> ?p ?o ?g. }

• W2075259252 endingPage "327" @default.
• W2075259252 startingPage "311" @default.
• W2075259252 abstract "Neutropenia, frequently a side effect of chemo- and radiotherapy, increases susceptibility to microbial infections and is a life-threatening condition. For realistically predicting drug treatment effects on granulopoiesis, we have constructed a new mathematical model of granulopoiesis in the bone marrow and in the peripheral blood, featuring cell cycle phase transition and detailed granulocyte-colony stimulating factor (G-CSF) pharmacokinetics (PK) and pharmacodynamics (PD), including intracellular second messenger. Using this model, in conjunction with clinical results, we evaluated the system parameters, implemented those in the model and successfully retrieved the results of several independent clinical experiments under a wide range of G-CSF regimens. Our results show that the introduction of G-CSF-controlled intracellular second messenger is indispensable for precise retrieval of the clinical results, and suggest that the half-life of this messenger varies between a single and multiple G-CSF administration schedules. In addition, our model provided reliable steady-state, as well as dynamic, estimations of human granulopoiesis parameters. These included an estimation of apoptosis index in the post-mitotic compartment, which corroborates previous results. At present the model is used for suggesting improved drug regimens." @default.
• W2075259252 created "2016-06-24" @default.
• W2075259252 creator A5000453185 @default.
• W2075259252 creator A5029011185 @default.
• W2075259252 creator A5049152177 @default.
• W2075259252 creator A5058673059 @default.
• W2075259252 creator A5068991790 @default.
• W2075259252 creator A5069914492 @default.
• W2075259252 date "2005-06-01" @default.
• W2075259252 modified "2023-10-17" @default.
• W2075259252 title "The complex effect of granulocyte colony-stimulating factor on human granulopoiesis analyzed by a new physiologically-based mathematical model" @default.
• W2075259252 cites W132149632 @default.
• W2075259252 cites W1867578926 @default.
• W2075259252 cites W1969606315 @default.
• W2075259252 cites W1971599842 @default.
• W2075259252 cites W1978464652 @default.
• W2075259252 cites W1989478899 @default.
• W2075259252 cites W1999884087 @default.
• W2075259252 cites W2004516409 @default.
• W2075259252 cites W2013301732 @default.
• W2075259252 cites W2013332168 @default.
• W2075259252 cites W2033215164 @default.
• W2075259252 cites W2034333141 @default.
• W2075259252 cites W2059002395 @default.
• W2075259252 cites W2074478439 @default.
• W2075259252 cites W2077077992 @default.
• W2075259252 cites W2077815466 @default.
• W2075259252 cites W2102783262 @default.
• W2075259252 cites W2121836801 @default.
• W2075259252 cites W2126244202 @default.
• W2075259252 cites W2139004304 @default.
• W2075259252 cites W2157821239 @default.
• W2075259252 cites W2158384232 @default.
• W2075259252 cites W2255700465 @default.
• W2075259252 cites W2400090911 @default.
• W2075259252 cites W2404959529 @default.
• W2075259252 cites W4249037581 @default.
• W2075259252 doi "https://doi.org/10.1016/j.jtbi.2004.11.026" @default.
• W2075259252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15784267" @default.
• W2075259252 hasPublicationYear "2005" @default.
• W2075259252 type Work @default.
• W2075259252 sameAs 2075259252 @default.
• W2075259252 citedByCount "49" @default.
• W2075259252 countsByYear W20752592522012 @default.
• W2075259252 countsByYear W20752592522013 @default.
• W2075259252 countsByYear W20752592522014 @default.
• W2075259252 countsByYear W20752592522015 @default.
• W2075259252 countsByYear W20752592522016 @default.
• W2075259252 countsByYear W20752592522017 @default.
• W2075259252 countsByYear W20752592522018 @default.
• W2075259252 countsByYear W20752592522019 @default.
• W2075259252 countsByYear W20752592522021 @default.
• W2075259252 crossrefType "journal-article" @default.
• W2075259252 hasAuthorship W2075259252A5000453185 @default.
• W2075259252 hasAuthorship W2075259252A5029011185 @default.
• W2075259252 hasAuthorship W2075259252A5049152177 @default.
• W2075259252 hasAuthorship W2075259252A5058673059 @default.
• W2075259252 hasAuthorship W2075259252A5068991790 @default.
• W2075259252 hasAuthorship W2075259252A5069914492 @default.
• W2075259252 hasConcept C109159458 @default.
• W2075259252 hasConcept C111113717 @default.
• W2075259252 hasConcept C112705442 @default.
• W2075259252 hasConcept C126322002 @default.
• W2075259252 hasConcept C163235415 @default.
• W2075259252 hasConcept C203014093 @default.
• W2075259252 hasConcept C2776694085 @default.
• W2075259252 hasConcept C2777063308 @default.
• W2075259252 hasConcept C2777767877 @default.
• W2075259252 hasConcept C2777983669 @default.
• W2075259252 hasConcept C2779452902 @default.
• W2075259252 hasConcept C2780007613 @default.
• W2075259252 hasConcept C2780035454 @default.
• W2075259252 hasConcept C28328180 @default.
• W2075259252 hasConcept C71924100 @default.
• W2075259252 hasConcept C79879829 @default.
• W2075259252 hasConcept C86803240 @default.
• W2075259252 hasConcept C880424 @default.
• W2075259252 hasConcept C95444343 @default.
• W2075259252 hasConcept C98274493 @default.
• W2075259252 hasConceptScore W2075259252C109159458 @default.
• W2075259252 hasConceptScore W2075259252C111113717 @default.
• W2075259252 hasConceptScore W2075259252C112705442 @default.
• W2075259252 hasConceptScore W2075259252C126322002 @default.
• W2075259252 hasConceptScore W2075259252C163235415 @default.
• W2075259252 hasConceptScore W2075259252C203014093 @default.
• W2075259252 hasConceptScore W2075259252C2776694085 @default.
• W2075259252 hasConceptScore W2075259252C2777063308 @default.
• W2075259252 hasConceptScore W2075259252C2777767877 @default.
• W2075259252 hasConceptScore W2075259252C2777983669 @default.
• W2075259252 hasConceptScore W2075259252C2779452902 @default.
• W2075259252 hasConceptScore W2075259252C2780007613 @default.
• W2075259252 hasConceptScore W2075259252C2780035454 @default.
• W2075259252 hasConceptScore W2075259252C28328180 @default.
• W2075259252 hasConceptScore W2075259252C71924100 @default.
• W2075259252 hasConceptScore W2075259252C79879829 @default.
• W2075259252 hasConceptScore W2075259252C86803240 @default.
• W2075259252 hasConceptScore W2075259252C880424 @default.
• W2075259252 hasConceptScore W2075259252C95444343 @default.

• next