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- W2075261737 abstract "The pre- and postjunctional affinity constants of a series of muscarinic antagonists were determined in guinea pig and rabbit irises. Field stimulation-evoked [3H]noradrenaline release from superfused isolated irises was concentration dependently inhibited by (±)-methacholine, confirming the presence on the iris noradrenergic nerves of prejunctional inhibitory muscarinic receptors. The affinity constants of the antagonists at the pre- and postjunctional receptors are compatible with the coexistence in the iris of two different M2 receptors: the cardiac (M2α) subtype on the noradrenergic nerves and the smooth muscle (M2β) subtype on the iris sphincter muscle. The rank order of potency of the antagonists studied at the prejunctional site was: atropine > himbacine . AF-DX 116 > pirenzepine > hexahydrosiladifenidol. The order of potency at the postjunctional receptors mediating the methacholine-induced isotonic contraction of the isolated rabbit iris sphincter was: atropine > hexahydrosiladifenidol > pirenzepine > himbacine > AF-DX 116." @default.
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- W2075261737 date "1989-04-01" @default.
- W2075261737 modified "2023-10-04" @default.
- W2075261737 title "M2 muscarinic receptors on the iris sphincter muscle differ from those on iris noradrenergic nerves" @default.
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- W2075261737 doi "https://doi.org/10.1016/0014-2999(89)90195-7" @default.
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