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• W2075285418 abstract "Glioblastoma patients spontaneously develop anti-tumour immune responses. However, the tumour itself develops several mechanisms that allow the tumor to escape the immune system. Clinical trials using infusion of activated autologous immune cells, or active immunotherapy with tumor antigens and dendritic cells have successfully induced anti-tumour immunity and some radiological responses. More recently, approaches targeting the mechanisms of tolerance have shown promising data in melanoma, and are currently under investigations in gliomas. However, large randomised trials are still needed to prove the usefulness of cancer vaccines in brain tumors. Malgré un traitement associant chirurgie, radiothérapie et chimiothérapie, le pronostic des glioblastomes reste péjoratif, soulignant la nécessité de nouveaux traitements. La meilleure compréhension du système immunitaire au sein du système nerveux central et la description de nouveaux antigènes tumoraux ont favorisé le développement de l’immunothérapie dans les tumeurs cérébrales. On distingue trois approches différentes. L’immunothérapie passive ou adoptive administre des cellules immunitaires autologues activées ex vivo. L’immunothérapie active stimule le système immunitaire en utilisant des antigènes tumoraux présents dans les cellules tumorales. Enfin, une approche qu’on pourrait qualifier de « correctrice » vise à neutraliser les mécanismes de tolérance immunitaire tumorale responsable de l’échappement thérapeutique." @default.
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• W2075285418 date "2011-10-01" @default.
• W2075285418 modified "2023-10-03" @default.
• W2075285418 title "Immunotherapy in human glioblastoma" @default.
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• W2075285418 doi "https://doi.org/10.1016/j.neurol.2011.07.002" @default.
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