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• W2075310611 abstract "Pre-eclampsia affects between 2% and 7% of all pregnant women, contributing to perinatal and maternal morbidity. There are conflicting data on plasma homocysteine and folate in pre-eclampsia, and little about fetal concentrations.Firstly, to compare the concentrations of homocysteine and folate in maternal and paired fetal (umbilical venous) plasma samples from normotensive or pre-eclamptic pregnancies at delivery; secondly, to identify any effect of parity on these concentrations.Hospital based cross-sectional study consisting of 24 normotensive and 16 pre-eclamptic pregnant White European women from whom maternal and fetal plasma samples were collected at delivery.Maternal and fetal plasma homocysteine and folate concentrations between normotensive and pre-eclamptic pregnancies with varying parity.There were no significant differences in either maternal or fetal plasma homocysteine or folate concentrations between normotensive and pre-eclamptic pregnancies, or between homocysteine and folate. In both the normotensive and pre-eclamptic women, plasma folate concentration was higher in paired fetal compared to maternal plasma (P<0.001 and P=0.047, respectively). With regards to homocysteine, only the normotensive samples had higher fetal concentrations (P=0.002). Both maternal and fetal plasma folate concentrations were lower in parous women (P=0.001 and P=0.017, respectively), the lowest concentrations being in pre-eclamptic parous women (P=0.004), but homocysteine concentrations were similar (P>0.4 for both).The low plasma folate in parous women is an interesting finding and, when intake is also low, may contribute to adverse pregnancy outcomes, particularly in relation to pre-eclampsia." @default.
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• W2075310611 date "2011-04-01" @default.
• W2075310611 modified "2023-10-18" @default.
• W2075310611 title "Homocysteine and folate plasma concentrations in mother and baby at delivery after pre-eclamptic or normotensive pregnancy: Influence of parity" @default.
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• W2075310611 doi "https://doi.org/10.1016/j.preghy.2011.01.006" @default.
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