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- W2075312858 endingPage "4336" @default.
- W2075312858 startingPage "4336" @default.
- W2075312858 abstract "Mounting evidence indicates that certain nucleotide sequences impose non-canonical secondary structures on DNA. The resulting variable conformations are thought to bestow on the DNA informational content additional to that encoded by its linear arrangement of bases. DNA sequences that include clusters of contiguous guanine residues readily form in vitro diverse types of four-stranded structures collectively named tetraplex or quadruplex DNA. Data suggest that tetraplex DNA structures are likely to be formed in vivo and to have roles in key biological processes such as regulation of gene transcription, maintenance of telomeres, DNA recombination and the packaging of retroviral genome. A credible argument for the existence of quadruplex DNA in vivo is the prevalence of numerous viral and cellular proteins that interact physically and functionally with tetrahelical DNA. Some such proteins bind selectively and tightly to tetraplex DNA, others promote the formation of DNA tetrahelices or act to unwind them, and several nucleases cleave tetraplex DNA preferentially. The protein-mediated structural transformations of quadruplex DNA and its selective nucleolytic cleavage argue strongly for transient formation of tetrahelical DNA in the cell. This review surveys tetraplex structures of DNA and their interacting proteins and appraises the evidence for their biological roles." @default.
- W2075312858 created "2016-06-24" @default.
- W2075312858 creator A5071181577 @default.
- W2075312858 date "2007-01-01" @default.
- W2075312858 modified "2023-10-10" @default.
- W2075312858 title "Tetraplex DNA and its interacting proteins" @default.
- W2075312858 cites W142039491 @default.
- W2075312858 cites W1484505342 @default.
- W2075312858 cites W1506201015 @default.
- W2075312858 cites W1510227107 @default.
- W2075312858 cites W1531073921 @default.
- W2075312858 cites W1550600895 @default.
- W2075312858 cites W1561471115 @default.
- W2075312858 cites W1605738254 @default.
- W2075312858 cites W164751788 @default.
- W2075312858 cites W1943069336 @default.
- W2075312858 cites W1964858690 @default.
- W2075312858 cites W1966489527 @default.
- W2075312858 cites W1968403527 @default.
- W2075312858 cites W1969862626 @default.
- W2075312858 cites W1974175020 @default.
- W2075312858 cites W1978830897 @default.
- W2075312858 cites W1980083127 @default.
- W2075312858 cites W1980513386 @default.
- W2075312858 cites W1980517167 @default.
- W2075312858 cites W1981203259 @default.
- W2075312858 cites W1981895660 @default.
- W2075312858 cites W1982322165 @default.
- W2075312858 cites W1983127291 @default.
- W2075312858 cites W1983365717 @default.
- W2075312858 cites W1983694849 @default.
- W2075312858 cites W1984288546 @default.
- W2075312858 cites W1986071629 @default.
- W2075312858 cites W1987110315 @default.
- W2075312858 cites W1988501617 @default.
- W2075312858 cites W1988631038 @default.
- W2075312858 cites W1990635146 @default.
- W2075312858 cites W1991590162 @default.
- W2075312858 cites W1992223960 @default.
- W2075312858 cites W1993656252 @default.
- W2075312858 cites W1997077880 @default.
- W2075312858 cites W1999900311 @default.
- W2075312858 cites W2000287747 @default.
- W2075312858 cites W2002780348 @default.
- W2075312858 cites W2003745942 @default.
- W2075312858 cites W2004721849 @default.
- W2075312858 cites W2005493974 @default.
- W2075312858 cites W2008320899 @default.
- W2075312858 cites W2008815082 @default.
- W2075312858 cites W2012072339 @default.
- W2075312858 cites W2014296143 @default.
- W2075312858 cites W2015625843 @default.
- W2075312858 cites W2018172829 @default.
- W2075312858 cites W2025133427 @default.
- W2075312858 cites W2025549692 @default.
- W2075312858 cites W2025757251 @default.
- W2075312858 cites W2026604399 @default.
- W2075312858 cites W2028342376 @default.
- W2075312858 cites W2028887586 @default.
- W2075312858 cites W2030132004 @default.
- W2075312858 cites W2032354651 @default.
- W2075312858 cites W2034468934 @default.
- W2075312858 cites W2034622045 @default.
- W2075312858 cites W2034955342 @default.
- W2075312858 cites W2035667154 @default.
- W2075312858 cites W2036277308 @default.
- W2075312858 cites W2038210262 @default.
- W2075312858 cites W2039658297 @default.
- W2075312858 cites W2042278282 @default.
- W2075312858 cites W2043253460 @default.
- W2075312858 cites W2043422640 @default.
- W2075312858 cites W2048460640 @default.
- W2075312858 cites W2048909999 @default.
- W2075312858 cites W2048910847 @default.
- W2075312858 cites W2051017508 @default.
- W2075312858 cites W2052024409 @default.
- W2075312858 cites W2052442164 @default.
- W2075312858 cites W2052968074 @default.
- W2075312858 cites W2055721693 @default.
- W2075312858 cites W2056313670 @default.
- W2075312858 cites W2058204977 @default.
- W2075312858 cites W2059355381 @default.
- W2075312858 cites W2060017837 @default.
- W2075312858 cites W2063288787 @default.
- W2075312858 cites W2067877700 @default.
- W2075312858 cites W2068509324 @default.
- W2075312858 cites W2068697291 @default.
- W2075312858 cites W2069865062 @default.
- W2075312858 cites W2072129659 @default.
- W2075312858 cites W2072910036 @default.
- W2075312858 cites W2073722866 @default.
- W2075312858 cites W2073989291 @default.
- W2075312858 cites W2075430707 @default.
- W2075312858 cites W2078428995 @default.
- W2075312858 cites W2080964082 @default.
- W2075312858 cites W2082738516 @default.
- W2075312858 cites W2085005678 @default.
- W2075312858 cites W2089355762 @default.