Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075315087> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2075315087 endingPage "252" @default.
- W2075315087 startingPage "246" @default.
- W2075315087 abstract "Studies have been conducted to examine the feasibility of preventing oxyradical-dependent oxidative stress to mouse lens in culture, using pyruvate as an antioxidant. The extent of oxidative damage to the tissue was assessed by measurement of the status of Na(+)-K(+) ATPase dependent active transport of rubidium 86Rb(+). The tissue levels of adenosine triphosphate (ATP), glutathione (GSH), malonaldehyde (MDA) and catalase were also determined. While the measurement of 86Rb(+) uptake provides an assessment of the integrity of the primary active transport system, measurement of the other components reflects the status of intracellular oxidative stress. ATP measurement also reflected on the overall status of metabolic integrity. Incubation of the lens with xanthine (XA)/xanthine oxidase (XO) system had an adverse effect on all these parameters. Incorporation of pyruvate was strikingly protective. The protective effect of pyruvate is apparently due to its ability to scavenge ROS generated in the medium with the possibility of its action on tissue metabolism as well. The findings are hence considered useful for further studies on the prevention of oxidative stress to tissues by exogenous supplementation with pyruvate, specially the human lens where the biochemistry of its antioxidant mechanisms is similar to the mouse lens, contrary to the rat lens." @default.
- W2075315087 created "2016-06-24" @default.
- W2075315087 creator A5003031323 @default.
- W2075315087 creator A5054362471 @default.
- W2075315087 creator A5074027668 @default.
- W2075315087 date "2003-06-01" @default.
- W2075315087 modified "2023-09-27" @default.
- W2075315087 title "Oxidative damage to mouse lens in culture. Protective effect of pyruvate" @default.
- W2075315087 cites W1500332700 @default.
- W2075315087 cites W1734082729 @default.
- W2075315087 cites W1981183816 @default.
- W2075315087 cites W1985928884 @default.
- W2075315087 cites W2002782207 @default.
- W2075315087 cites W2006272169 @default.
- W2075315087 cites W2011156783 @default.
- W2075315087 cites W2012400930 @default.
- W2075315087 cites W2028468492 @default.
- W2075315087 cites W2056168344 @default.
- W2075315087 cites W2057909461 @default.
- W2075315087 cites W2061291153 @default.
- W2075315087 cites W2070828755 @default.
- W2075315087 cites W2086031795 @default.
- W2075315087 cites W2089000811 @default.
- W2075315087 cites W2089319597 @default.
- W2075315087 cites W2124463769 @default.
- W2075315087 cites W2154086349 @default.
- W2075315087 cites W2159572532 @default.
- W2075315087 cites W2201344815 @default.
- W2075315087 cites W2319186233 @default.
- W2075315087 doi "https://doi.org/10.1016/s0304-4165(03)00075-8" @default.
- W2075315087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12787921" @default.
- W2075315087 hasPublicationYear "2003" @default.
- W2075315087 type Work @default.
- W2075315087 sameAs 2075315087 @default.
- W2075315087 citedByCount "39" @default.
- W2075315087 countsByYear W20753150872013 @default.
- W2075315087 countsByYear W20753150872015 @default.
- W2075315087 countsByYear W20753150872016 @default.
- W2075315087 countsByYear W20753150872019 @default.
- W2075315087 countsByYear W20753150872021 @default.
- W2075315087 countsByYear W20753150872022 @default.
- W2075315087 countsByYear W20753150872023 @default.
- W2075315087 crossrefType "journal-article" @default.
- W2075315087 hasAuthorship W2075315087A5003031323 @default.
- W2075315087 hasAuthorship W2075315087A5054362471 @default.
- W2075315087 hasAuthorship W2075315087A5074027668 @default.
- W2075315087 hasConcept C181199279 @default.
- W2075315087 hasConcept C185592680 @default.
- W2075315087 hasConcept C20251656 @default.
- W2075315087 hasConcept C2776151105 @default.
- W2075315087 hasConcept C2778004101 @default.
- W2075315087 hasConcept C2778102346 @default.
- W2075315087 hasConcept C2778979269 @default.
- W2075315087 hasConcept C2779470414 @default.
- W2075315087 hasConcept C2779564974 @default.
- W2075315087 hasConcept C48349386 @default.
- W2075315087 hasConcept C538909803 @default.
- W2075315087 hasConcept C55493867 @default.
- W2075315087 hasConcept C57600042 @default.
- W2075315087 hasConcept C62231903 @default.
- W2075315087 hasConcept C86803240 @default.
- W2075315087 hasConceptScore W2075315087C181199279 @default.
- W2075315087 hasConceptScore W2075315087C185592680 @default.
- W2075315087 hasConceptScore W2075315087C20251656 @default.
- W2075315087 hasConceptScore W2075315087C2776151105 @default.
- W2075315087 hasConceptScore W2075315087C2778004101 @default.
- W2075315087 hasConceptScore W2075315087C2778102346 @default.
- W2075315087 hasConceptScore W2075315087C2778979269 @default.
- W2075315087 hasConceptScore W2075315087C2779470414 @default.
- W2075315087 hasConceptScore W2075315087C2779564974 @default.
- W2075315087 hasConceptScore W2075315087C48349386 @default.
- W2075315087 hasConceptScore W2075315087C538909803 @default.
- W2075315087 hasConceptScore W2075315087C55493867 @default.
- W2075315087 hasConceptScore W2075315087C57600042 @default.
- W2075315087 hasConceptScore W2075315087C62231903 @default.
- W2075315087 hasConceptScore W2075315087C86803240 @default.
- W2075315087 hasIssue "3" @default.
- W2075315087 hasLocation W20753150871 @default.
- W2075315087 hasLocation W20753150872 @default.
- W2075315087 hasOpenAccess W2075315087 @default.
- W2075315087 hasPrimaryLocation W20753150871 @default.
- W2075315087 hasRelatedWork W1443871574 @default.
- W2075315087 hasRelatedWork W1807700271 @default.
- W2075315087 hasRelatedWork W1979054717 @default.
- W2075315087 hasRelatedWork W2050588921 @default.
- W2075315087 hasRelatedWork W2107263799 @default.
- W2075315087 hasRelatedWork W2374558055 @default.
- W2075315087 hasRelatedWork W2737873067 @default.
- W2075315087 hasRelatedWork W3082631906 @default.
- W2075315087 hasRelatedWork W3214962737 @default.
- W2075315087 hasRelatedWork W3214998341 @default.
- W2075315087 hasVolume "1621" @default.
- W2075315087 isParatext "false" @default.
- W2075315087 isRetracted "false" @default.
- W2075315087 magId "2075315087" @default.
- W2075315087 workType "article" @default.