FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075319022> ?p ?o ?g. }

• W2075319022 endingPage "8618" @default.
• W2075319022 startingPage "8613" @default.
• W2075319022 abstract "The mechanism of N-tetrazole ring formation at the distal histidyl imidazole of sperm whale myoglobin (Mb) has been studied by nitrogen-15 (15N) NMR spectroscopy by utilizing 15N-labeled cyanogen bromide (BrCN) and azide ion (N3-). The 15N-NMR spectrum of BrC15N-modified Mb + N3- afforded two hyperfine-shifted 15N resonances, both of which are identical with the resonance positions of two of the three 15N resonances for BrCN-modified Mb + 15NN2-. This unusual spectral feature is due to the formation of the N-tetrazole ring attached to the distal histidyl imidazole and the scrambling of the labeled nitrogen originated from N3- or BrCN over the tetrazole ring upon coordination to the ferric heme iron. The ferric iron-bound N-tetrazole ring comes off upon reduction to the ferrous state, and the stable CO complex of tetrazole-modified Mb (tetrazole-Mb) is formed. Electronic absorption and 1H-NMR spectra of deoxy and carbonmonoxy forms of tetrazole-Mb are slightly altered from those of native Mb by the modification, while the most significant effect is exerted on the C-O stretching frequency of iron-bound CO. The C-O stretching band for tetrazole-MbCO is observed at 1966 cm-1 in contrast to 1945 cm-1 for native MbCO, suggesting that the geometry of iron-bound CO in tetrazole-Mb is relatively upright which is characteristic of the open conformer. This result corresponds to the 15-fold increase of the CO association rate constant by the N-tetrazole modification of the distal His. The oxy form of tetrazole-Mb is readily autoxidized to its ferric state, indicating that hydrogen bonding between the distal His and iron-bound oxygen is essential for stable O2 binding to the heme iron." @default.
• W2075319022 created "2016-06-24" @default.
• W2075319022 creator A5031074186 @default.
• W2075319022 creator A5066417397 @default.
• W2075319022 date "1992-09-15" @default.
• W2075319022 modified "2023-09-24" @default.
• W2075319022 title "Modification of the distal histidyl imidazole in myogloblin to N-tetrazole-substituted imidazole and its effects on the heme environmental structure and ligand binding properties" @default.
• W2075319022 cites W1492848568 @default.
• W2075319022 cites W1503934385 @default.
• W2075319022 cites W1512775211 @default.
• W2075319022 cites W1514532383 @default.
• W2075319022 cites W1566053729 @default.
• W2075319022 cites W1593783655 @default.
• W2075319022 cites W1601173997 @default.
• W2075319022 cites W1735706741 @default.
• W2075319022 cites W1967756024 @default.
• W2075319022 cites W1967979919 @default.
• W2075319022 cites W1980097478 @default.
• W2075319022 cites W1982077069 @default.
• W2075319022 cites W1986999530 @default.
• W2075319022 cites W2008407134 @default.
• W2075319022 cites W2017981842 @default.
• W2075319022 cites W2019083993 @default.
• W2075319022 cites W2024495148 @default.
• W2075319022 cites W2026227505 @default.
• W2075319022 cites W2026237439 @default.
• W2075319022 cites W2030568700 @default.
• W2075319022 cites W2061066489 @default.
• W2075319022 cites W2064212205 @default.
• W2075319022 cites W2064635496 @default.
• W2075319022 cites W2068966023 @default.
• W2075319022 cites W2081405297 @default.
• W2075319022 cites W2083528812 @default.
• W2075319022 cites W2142897804 @default.
• W2075319022 doi "https://doi.org/10.1021/bi00151a031" @default.
• W2075319022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1390645" @default.
• W2075319022 hasPublicationYear "1992" @default.
• W2075319022 type Work @default.
• W2075319022 sameAs 2075319022 @default.
• W2075319022 citedByCount "10" @default.
• W2075319022 countsByYear W20753190222012 @default.
• W2075319022 countsByYear W20753190222016 @default.
• W2075319022 crossrefType "journal-article" @default.
• W2075319022 hasAuthorship W2075319022A5031074186 @default.
• W2075319022 hasAuthorship W2075319022A5066417397 @default.
• W2075319022 hasConcept C116569031 @default.
• W2075319022 hasConcept C170493617 @default.
• W2075319022 hasConcept C178790620 @default.
• W2075319022 hasConcept C179104552 @default.
• W2075319022 hasConcept C185592680 @default.
• W2075319022 hasConcept C2775832776 @default.
• W2075319022 hasConcept C2778063876 @default.
• W2075319022 hasConcept C2778455166 @default.
• W2075319022 hasConcept C2780534640 @default.
• W2075319022 hasConcept C2780827033 @default.
• W2075319022 hasConcept C2780874372 @default.
• W2075319022 hasConcept C2780997848 @default.
• W2075319022 hasConcept C55493867 @default.
• W2075319022 hasConcept C71240020 @default.
• W2075319022 hasConcept C8010536 @default.
• W2075319022 hasConceptScore W2075319022C116569031 @default.
• W2075319022 hasConceptScore W2075319022C170493617 @default.
• W2075319022 hasConceptScore W2075319022C178790620 @default.
• W2075319022 hasConceptScore W2075319022C179104552 @default.
• W2075319022 hasConceptScore W2075319022C185592680 @default.
• W2075319022 hasConceptScore W2075319022C2775832776 @default.
• W2075319022 hasConceptScore W2075319022C2778063876 @default.
• W2075319022 hasConceptScore W2075319022C2778455166 @default.
• W2075319022 hasConceptScore W2075319022C2780534640 @default.
• W2075319022 hasConceptScore W2075319022C2780827033 @default.
• W2075319022 hasConceptScore W2075319022C2780874372 @default.
• W2075319022 hasConceptScore W2075319022C2780997848 @default.
• W2075319022 hasConceptScore W2075319022C55493867 @default.
• W2075319022 hasConceptScore W2075319022C71240020 @default.
• W2075319022 hasConceptScore W2075319022C8010536 @default.
• W2075319022 hasIssue "36" @default.
• W2075319022 hasLocation W20753190221 @default.
• W2075319022 hasLocation W20753190222 @default.
• W2075319022 hasOpenAccess W2075319022 @default.
• W2075319022 hasPrimaryLocation W20753190221 @default.
• W2075319022 hasRelatedWork W1965787155 @default.
• W2075319022 hasRelatedWork W1979675908 @default.
• W2075319022 hasRelatedWork W1993783743 @default.
• W2075319022 hasRelatedWork W2006065280 @default.
• W2075319022 hasRelatedWork W2009049338 @default.
• W2075319022 hasRelatedWork W2032533435 @default.
• W2075319022 hasRelatedWork W2042488599 @default.
• W2075319022 hasRelatedWork W2058788084 @default.
• W2075319022 hasRelatedWork W2075319022 @default.
• W2075319022 hasRelatedWork W2154861470 @default.
• W2075319022 hasVolume "31" @default.
• W2075319022 isParatext "false" @default.
• W2075319022 isRetracted "false" @default.
• W2075319022 magId "2075319022" @default.
• W2075319022 workType "article" @default.