FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075325717> ?p ?o ?g. }

• W2075325717 endingPage "e1567" @default.
• W2075325717 startingPage "e1567" @default.
• W2075325717 abstract "Adult human adipose-derived mesenchymal stem cells (hAMSCs) are multipotent cells, which are abundant, easily collected, and bypass the ethical concerns that plague embryonic stem cells. Their utility and accessibility have led to the rapid development of clinical investigations to explore their autologous and allogeneic cellular-based regenerative potential, tissue preservation capabilities, anti-inflammatory properties, and anticancer properties, among others. hAMSCs are typically cultured under ambient conditions with 21% oxygen. However, physiologically, hAMSCs exist in an environment of much lower oxygen tension. Furthermore, hAMSCs cultured in standard conditions have shown limited proliferative and migratory capabilities, as well as limited viability. This study investigated the effects hypoxic culture conditions have on primary intraoperatively derived hAMSCs. hAMSCs cultured under hypoxia (hAMSCs-H) remained multipotent, capable of differentiation into osteogenic, chondrogenic, and adipogenic lineages. In addition, hAMSCs-H grew faster and exhibited less cell death. Furthermore, hAMSCs-H had greater motility than normoxia-cultured hAMSCs and exhibited greater homing ability to glioblastoma (GBM) derived from brain tumor-initiating cells from our patients in vitro and in vivo. Importantly, hAMSCs-H did not transform into tumor-associated fibroblasts in vitro and were not tumorigenic in vivo. Rather, hAMSCs-H promoted the differentiation of brain cancer cells in vitro and in vivo. These findings suggest an alternative culturing technique that can enhance the function of hAMSCs, which may be necessary for their use in the treatment of various pathologies including stroke, myocardial infarction, amyotrophic lateral sclerosis, and GBM." @default.
• W2075325717 created "2016-06-24" @default.
• W2075325717 creator A5004984662 @default.
• W2075325717 creator A5006492516 @default.
• W2075325717 creator A5018571414 @default.
• W2075325717 creator A5020336281 @default.
• W2075325717 creator A5031431944 @default.
• W2075325717 creator A5043996472 @default.
• W2075325717 creator A5044405131 @default.
• W2075325717 creator A5053442504 @default.
• W2075325717 creator A5062292317 @default.
• W2075325717 creator A5069989446 @default.
• W2075325717 creator A5079298262 @default.
• W2075325717 creator A5089579710 @default.
• W2075325717 creator A5090888787 @default.
• W2075325717 date "2014-12-11" @default.
• W2075325717 modified "2023-10-15" @default.
• W2075325717 title "Hypoxia-cultured human adipose-derived mesenchymal stem cells are non-oncogenic and have enhanced viability, motility, and tropism to brain cancer" @default.
• W2075325717 cites W1787633345 @default.
• W2075325717 cites W1891249103 @default.
• W2075325717 cites W1966611280 @default.
• W2075325717 cites W1977979138 @default.
• W2075325717 cites W1979062387 @default.
• W2075325717 cites W1979704965 @default.
• W2075325717 cites W1981055008 @default.
• W2075325717 cites W1987672321 @default.
• W2075325717 cites W1998461585 @default.
• W2075325717 cites W2002325129 @default.
• W2075325717 cites W2002620928 @default.
• W2075325717 cites W2003345391 @default.
• W2075325717 cites W2012060637 @default.
• W2075325717 cites W2017251212 @default.
• W2075325717 cites W2017720509 @default.
• W2075325717 cites W2019787798 @default.
• W2075325717 cites W2020578714 @default.
• W2075325717 cites W2025371271 @default.
• W2075325717 cites W2035985988 @default.
• W2075325717 cites W2038629933 @default.
• W2075325717 cites W2039554136 @default.
• W2075325717 cites W2044322920 @default.
• W2075325717 cites W2056510698 @default.
• W2075325717 cites W2063243732 @default.
• W2075325717 cites W2064489225 @default.
• W2075325717 cites W2067978197 @default.
• W2075325717 cites W2069440880 @default.
• W2075325717 cites W2076310492 @default.
• W2075325717 cites W2083225173 @default.
• W2075325717 cites W2084371510 @default.
• W2075325717 cites W2085582924 @default.
• W2075325717 cites W2089530989 @default.
• W2075325717 cites W2090548715 @default.
• W2075325717 cites W2091128115 @default.
• W2075325717 cites W2096287682 @default.
• W2075325717 cites W2096338956 @default.
• W2075325717 cites W2097219537 @default.
• W2075325717 cites W2102638899 @default.
• W2075325717 cites W2107576615 @default.
• W2075325717 cites W2110820685 @default.
• W2075325717 cites W2111665285 @default.
• W2075325717 cites W2113942802 @default.
• W2075325717 cites W2116310267 @default.
• W2075325717 cites W2119000874 @default.
• W2075325717 cites W2120100866 @default.
• W2075325717 cites W2120657513 @default.
• W2075325717 cites W2131624895 @default.
• W2075325717 cites W2138953281 @default.
• W2075325717 cites W2140165290 @default.
• W2075325717 cites W2143408624 @default.
• W2075325717 cites W2143904629 @default.
• W2075325717 cites W2154421013 @default.
• W2075325717 cites W2161214210 @default.
• W2075325717 cites W2164032925 @default.
• W2075325717 cites W2165370359 @default.
• W2075325717 cites W2166582490 @default.
• W2075325717 cites W2169664936 @default.
• W2075325717 cites W2745974506 @default.
• W2075325717 cites W4211083917 @default.
• W2075325717 doi "https://doi.org/10.1038/cddis.2014.521" @default.
• W2075325717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4669846" @default.
• W2075325717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26111059" @default.
• W2075325717 hasPublicationYear "2014" @default.
• W2075325717 type Work @default.
• W2075325717 sameAs 2075325717 @default.
• W2075325717 citedByCount "59" @default.
• W2075325717 countsByYear W20753257172015 @default.
• W2075325717 countsByYear W20753257172016 @default.
• W2075325717 countsByYear W20753257172017 @default.
• W2075325717 countsByYear W20753257172018 @default.
• W2075325717 countsByYear W20753257172019 @default.
• W2075325717 countsByYear W20753257172020 @default.
• W2075325717 countsByYear W20753257172021 @default.
• W2075325717 countsByYear W20753257172022 @default.
• W2075325717 countsByYear W20753257172023 @default.
• W2075325717 crossrefType "journal-article" @default.
• W2075325717 hasAuthorship W2075325717A5004984662 @default.
• W2075325717 hasAuthorship W2075325717A5006492516 @default.
• W2075325717 hasAuthorship W2075325717A5018571414 @default.
• W2075325717 hasAuthorship W2075325717A5020336281 @default.

• next