FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075326467> ?p ?o ?g. }

• W2075326467 endingPage "99" @default.
• W2075326467 startingPage "99" @default.
• W2075326467 abstract "Background: Cyclic guanosine monophosphate (cGMP) and opioid receptors are involved in the modulation of nociception. Although the opioid receptors agonists are active in pain, the effect of an phospodiesterase inhibitor (zaprinast) for increasing the level of cGMP has not been thoroughly investigated at the spinal level. This study examined the effects of intrathecal zaprinast and morphine in a nociceptive test and we also examined the nature of the pharmacological interaction after the coadministration of zaprinast with morphine. The role of the nitric oxide (NO)-cGMP-potassium channel pathway on the effect of zaprinast was further clarified. Methods: Catheters were inserted into the intrathecal space of male SD rats. For the induction of pain, 50 of 5% formalin solution was applied to the hindpaw. Isobolographic analysis was used for the evaluation of the drug interaction between zaprinast and morphine. Furthermore, NO synthase inhibitor (), guanylyl cyclase inhibitor (ODQ) or a potassium channel blocker (glibenclamide) were intrathecally administered to verify the involvement of the NO-cGMP- potassium channel pathway on the antinociception effect of zaprinast. Results: Both zaprinast and morphine produced an antinociceptive effect during phase 1 and phase 2 in the formalin test. Isobolographic analysis revealed a synergistic interaction after the intrathecal administration of the zaprinast-morphine mixture in both phases. Intrathecal , ODQ and glibenclamide did not reverse the antinociception of zaprinast in either phase. Conclusions: These results suggest that zaprinast, morphine and the mixture of the two drugs are effective against acute pain and they facilitated pain state at the spinal level. Thus, the spinal combination of zaprinast with morphine may be useful for the management of pain. However, the NO-sensitive cGMP-potassium channel pathway did not contribute to the antinocieptive mechanism of zaprinast in the spinal cord." @default.
• W2075326467 created "2016-06-24" @default.
• W2075326467 creator A5007862324 @default.
• W2075326467 creator A5024811015 @default.
• W2075326467 creator A5029230287 @default.
• W2075326467 creator A5037001108 @default.
• W2075326467 creator A5048605541 @default.
• W2075326467 creator A5068431365 @default.
• W2075326467 date "2005-01-01" @default.
• W2075326467 modified "2023-09-28" @default.
• W2075326467 title "Antinociceptive Effect of the Intrathecal Phosphodiesterase Inhibitor, Zaprinast, in a Rat Formalin Test" @default.
• W2075326467 cites W1511156825 @default.
• W2075326467 cites W1969017417 @default.
• W2075326467 cites W1974097640 @default.
• W2075326467 cites W1978979929 @default.
• W2075326467 cites W1979254966 @default.
• W2075326467 cites W1980984957 @default.
• W2075326467 cites W1990726828 @default.
• W2075326467 cites W1996549484 @default.
• W2075326467 cites W1998744543 @default.
• W2075326467 cites W1999908521 @default.
• W2075326467 cites W2000468755 @default.
• W2075326467 cites W2017973604 @default.
• W2075326467 cites W2026745742 @default.
• W2075326467 cites W2039156019 @default.
• W2075326467 cites W2040725197 @default.
• W2075326467 cites W2045886062 @default.
• W2075326467 cites W2048401767 @default.
• W2075326467 cites W2053933048 @default.
• W2075326467 cites W2056099225 @default.
• W2075326467 cites W2057762723 @default.
• W2075326467 cites W2063680573 @default.
• W2075326467 cites W2068575727 @default.
• W2075326467 cites W2071010033 @default.
• W2075326467 cites W2071331983 @default.
• W2075326467 cites W2071513511 @default.
• W2075326467 cites W2072253551 @default.
• W2075326467 cites W2088379827 @default.
• W2075326467 cites W2095485479 @default.
• W2075326467 cites W2100530619 @default.
• W2075326467 cites W2104460771 @default.
• W2075326467 cites W2116738383 @default.
• W2075326467 cites W2128466718 @default.
• W2075326467 cites W2151482983 @default.
• W2075326467 cites W2166389885 @default.
• W2075326467 cites W2313326603 @default.
• W2075326467 cites W4255795179 @default.
• W2075326467 cites W95567247 @default.
• W2075326467 doi "https://doi.org/10.3344/kjp.2005.18.2.99" @default.
• W2075326467 hasPublicationYear "2005" @default.
• W2075326467 type Work @default.
• W2075326467 sameAs 2075326467 @default.
• W2075326467 citedByCount "4" @default.
• W2075326467 countsByYear W20753264672017 @default.
• W2075326467 countsByYear W20753264672018 @default.
• W2075326467 countsByYear W20753264672019 @default.
• W2075326467 countsByYear W20753264672023 @default.
• W2075326467 crossrefType "journal-article" @default.
• W2075326467 hasAuthorship W2075326467A5007862324 @default.
• W2075326467 hasAuthorship W2075326467A5024811015 @default.
• W2075326467 hasAuthorship W2075326467A5029230287 @default.
• W2075326467 hasAuthorship W2075326467A5037001108 @default.
• W2075326467 hasAuthorship W2075326467A5048605541 @default.
• W2075326467 hasAuthorship W2075326467A5068431365 @default.
• W2075326467 hasConcept C126322002 @default.
• W2075326467 hasConcept C15490471 @default.
• W2075326467 hasConcept C157820659 @default.
• W2075326467 hasConcept C170493617 @default.
• W2075326467 hasConcept C181199279 @default.
• W2075326467 hasConcept C185592680 @default.
• W2075326467 hasConcept C2776766087 @default.
• W2075326467 hasConcept C2776768464 @default.
• W2075326467 hasConcept C2776846068 @default.
• W2075326467 hasConcept C42219234 @default.
• W2075326467 hasConcept C55493867 @default.
• W2075326467 hasConcept C62826618 @default.
• W2075326467 hasConcept C71924100 @default.
• W2075326467 hasConcept C74534348 @default.
• W2075326467 hasConcept C98274493 @default.
• W2075326467 hasConceptScore W2075326467C126322002 @default.
• W2075326467 hasConceptScore W2075326467C15490471 @default.
• W2075326467 hasConceptScore W2075326467C157820659 @default.
• W2075326467 hasConceptScore W2075326467C170493617 @default.
• W2075326467 hasConceptScore W2075326467C181199279 @default.
• W2075326467 hasConceptScore W2075326467C185592680 @default.
• W2075326467 hasConceptScore W2075326467C2776766087 @default.
• W2075326467 hasConceptScore W2075326467C2776768464 @default.
• W2075326467 hasConceptScore W2075326467C2776846068 @default.
• W2075326467 hasConceptScore W2075326467C42219234 @default.
• W2075326467 hasConceptScore W2075326467C55493867 @default.
• W2075326467 hasConceptScore W2075326467C62826618 @default.
• W2075326467 hasConceptScore W2075326467C71924100 @default.
• W2075326467 hasConceptScore W2075326467C74534348 @default.
• W2075326467 hasConceptScore W2075326467C98274493 @default.
• W2075326467 hasIssue "2" @default.
• W2075326467 hasLocation W20753264671 @default.
• W2075326467 hasOpenAccess W2075326467 @default.
• W2075326467 hasPrimaryLocation W20753264671 @default.

• next