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• W2075326818 endingPage "e71739" @default.
• W2075326818 startingPage "e71739" @default.
• W2075326818 abstract "Intracellular composition and the distribution of bio-molecules play central roles in the specification of cell fates and morphogenesis during embryogenesis. Consequently, investigation of changes in the expression and distribution of bio-molecules, especially mRNAs and proteins, is an important challenge in developmental biology. Raman spectroscopic imaging, a non-invasive and label-free technique, allows simultaneous imaging of the intracellular composition and distribution of multiple bio-molecules. In this study, we explored the application of Raman spectroscopic imaging in the whole Ciona intestinalis embryo during development. Analysis of Raman spectra scattered from C. intestinalis embryos revealed a number of localized patterns of high Raman intensity within the embryo. Based on the observed distribution of bio-molecules, we succeeded in identifying the location and structure of differentiated muscle and endoderm within the whole embryo, up to the tailbud stage, in a label-free manner. Furthermore, during cell differentiation, we detected significant differences in cell state between muscle/endoderm daughter cells and daughter cells with other fates that had divided from the same mother cells; this was achieved by focusing on the Raman intensity of single Raman bands at 1002 or 1526 cm−1, respectively. This study reports the first application of Raman spectroscopic imaging to the study of identifying and characterizing differentiating tissues in a whole chordate embryo. Our results suggest that Raman spectroscopic imaging is a feasible label-free technique for investigating the developmental process of the whole embryo of C. intestinalis." @default.
• W2075326818 created "2016-06-24" @default.
• W2075326818 creator A5026621512 @default.
• W2075326818 creator A5043135854 @default.
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• W2075326818 date "2013-08-20" @default.
• W2075326818 modified "2023-10-17" @default.
• W2075326818 title "Raman Spectroscopic Imaging of the Whole Ciona intestinalis Embryo during Development" @default.
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• W2075326818 doi "https://doi.org/10.1371/journal.pone.0071739" @default.
• W2075326818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3748111" @default.
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• W2075326818 hasPublicationYear "2013" @default.
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