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• W2075326967 abstract "<h2>Abstract</h2> Intracranial atherosclerosis is associated with recurrent ischemic stroke. High-resolution MRI (HR MRI) can provide information about atheroma <i>in vivo</i>. We aimed to analyze and compare vascular wall imaging characteristics between patients with symptomatic and asymptomatic atherosclerotic stenosis of the middle cerebral artery (MCA) using 3.0 Tesla HR MRI. The HR MRI protocol included four different scans: black blood T1-weighted, T2-weighted and proton density-weighted MRI, as well as three-dimensional turbo spin echo imaging techniques with multiplanar reconstruction. Plaque characteristics, including location, morphology, and signal intensity, were analyzed in 51 patients (29 symptomatic, 22 asymptomatic) with atherosclerotic stenosis of the middle cerebral artery. The vessel wall area, lumen area, and plaque area (PA) were also calculated and compared between the symptomatic and asymptomatic groups. We found that PA, remodeling index (RI), and positive remodeling (PR) prevalence were significantly greater in the symptomatic group than in the asymptomatic group (PA: <i>p</i>=0.033; RI: <i>p</i>=0.020; PR: <i>p</i>=0.032). Plaque location in the superior aspect of the vessel wall and irregular plaque surface were more frequently observed in the symptomatic group than in the asymptomatic group (superior location: <i>p</i>=0.031; irregular surface: <i>p</i>=0.036). Moreover, multivariate logistic regression identified plaque location on the superior wall as an independent predictor of symptomatic MCA stenosis (odds ratio: 4.471; <i>p</i>=0.039). Therefore, we can conclude that patients with symptomatic atherosclerotic stenosis of the MCA are more likely to have larger plaques, PR, superiorly located plaques, and irregular plaque surface. These characteristics are promising factors for stratifying stroke risk." @default.
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• W2075326967 date "2015-04-01" @default.
• W2075326967 modified "2023-09-23" @default.
• W2075326967 title "High-resolution MRI of the vessel wall in patients with symptomatic atherosclerotic stenosis of the middle cerebral artery" @default.
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• W2075326967 doi "https://doi.org/10.1016/j.jocn.2014.10.018" @default.
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