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- W2075327813 abstract "Morphometric measurements were made of 143 glomerular-arteriolar pairs from normal portions of 10 kidneys removed for cancer. Compared with 70 normal arterioles, 38 afferent arterioles with nonobstructive hyaline deposits had larger lumens: Area: 416 ± 245 vs 203 ± 160μ2, p = .0000; Diameter: 15.7 ± 4.8 vs 11.7 ± 3.9μ, p = .0000. Circumference of these arterioles was also greater: 147 ± 66 vs 94 ± 49μ, p = .0000. The muscularis beneath deposits was thinner than in the rest of the arteriole (7.8 ± 3.9 vs 16.5 ± 5.7μ, p = .0000. Associated glomeruli had greater overall capillary surface area (13,242 ± 5,670 vs 11,069 ± 5,897μ2, p = .0337), with larger hilar capillaries (706 ± 1038 vs 275 ± 455μ2, p = .0024) and larger individual peripheral capillaries (96 ± 29 vs 84 ± 28μ2, p = .0476). There was a good correlation between area of arteriolar lumen and area of individual capillaries, both for normal arterioles (r = .3192, p<.0001) and for arterioles with nonobstructive hyaline deposits (r = .4693, p<.0001). Arterioles with hyaline deposits partially obstructing the lumen were less frequent (19/57 = 33% of cases), showed no overall differences in area of lumen from normal arterioles and were not significantly correlated with capillary size (r = -.1137, NS). Thus, hyaline arteriolosclerosis in its initial phases does not appear to impede blood flow but rather, given the larger lumens and larger glomerular capillary loops, may be a rough indicator of hyperperfusion and loss of autoregulation, perhaps as a function of the associated thinning and degeneration of the underlying smooth muscle." @default.
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- W2075327813 date "2001-11-01" @default.
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- W2075327813 title "Renal hyaline arteriolosclerosis - a marker for loss of autoregulation?" @default.
- W2075327813 doi "https://doi.org/10.1016/s0895-7061(01)01814-3" @default.
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