FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075329969> ?p ?o ?g. }

• W2075329969 endingPage "62" @default.
• W2075329969 startingPage "54" @default.
• W2075329969 abstract "Cyclin-dependent kinase 5 (Cdk5) is associated with synaptic plasticity and cognitive function. Previous reports have demonstrated that Cdk5 is necessary for memory formation, although others have reported Cdk5 conditional knockout mouse models exhibiting enhanced learning and memory. Furthermore, how Cdk5 acts in specific cell populations to affect behavior and cognitive outcomes remains unclear. Here we conduct a behavioral characterization of a forebrain-specific Cdk5 conditional knockout mouse model under the αCaMKII promoter, in which Cdk5 is ablated in excitatory pyramidal neurons of the forebrain. The Cdk5 conditional knockouts exhibit hyperactivity in the open field, reduced anxiety, and reduced behavioral despair. Moreover, the Cdk5 conditional knockouts also display impaired spatial learning in the Morris water maze and are severely impaired in contextual fear memory, which correspond to deficits in synaptic transmission. Remarkably, the hyperactivity of the Cdk5 conditional knockouts can be ameliorated by the administration of lithium chloride, an inhibitor of GSK3β signaling. Collectively, our data reveal that Cdk5 ablation from forebrain excitatory neurons results in deleterious effects on emotional and cognitive behavior and highlight a key role for Cdk5 in regulating the GSK3β signaling pathway." @default.
• W2075329969 created "2016-06-24" @default.
• W2075329969 creator A5016801481 @default.
• W2075329969 creator A5042440695 @default.
• W2075329969 creator A5050592402 @default.
• W2075329969 creator A5081776412 @default.
• W2075329969 date "2013-10-01" @default.
• W2075329969 modified "2023-10-01" @default.
• W2075329969 title "Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment" @default.
• W2075329969 cites W1760380374 @default.
• W2075329969 cites W1963600261 @default.
• W2075329969 cites W1971468364 @default.
• W2075329969 cites W1992491411 @default.
• W2075329969 cites W2011573205 @default.
• W2075329969 cites W2032244100 @default.
• W2075329969 cites W2038901745 @default.
• W2075329969 cites W2041341336 @default.
• W2075329969 cites W2042022467 @default.
• W2075329969 cites W2078708066 @default.
• W2075329969 cites W2079363406 @default.
• W2075329969 cites W2082443574 @default.
• W2075329969 cites W2090521738 @default.
• W2075329969 cites W2101974166 @default.
• W2075329969 cites W2102256305 @default.
• W2075329969 cites W2115920804 @default.
• W2075329969 cites W2128514286 @default.
• W2075329969 cites W2131863923 @default.
• W2075329969 cites W2153043611 @default.
• W2075329969 cites W2159663149 @default.
• W2075329969 cites W2162583663 @default.
• W2075329969 cites W2169105392 @default.
• W2075329969 doi "https://doi.org/10.1016/j.nlm.2013.06.016" @default.
• W2075329969 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3775577" @default.
• W2075329969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23850563" @default.
• W2075329969 hasPublicationYear "2013" @default.
• W2075329969 type Work @default.
• W2075329969 sameAs 2075329969 @default.
• W2075329969 citedByCount "19" @default.
• W2075329969 countsByYear W20753299692014 @default.
• W2075329969 countsByYear W20753299692015 @default.
• W2075329969 countsByYear W20753299692016 @default.
• W2075329969 countsByYear W20753299692018 @default.
• W2075329969 countsByYear W20753299692019 @default.
• W2075329969 countsByYear W20753299692020 @default.
• W2075329969 countsByYear W20753299692021 @default.
• W2075329969 countsByYear W20753299692022 @default.
• W2075329969 crossrefType "journal-article" @default.
• W2075329969 hasAuthorship W2075329969A5016801481 @default.
• W2075329969 hasAuthorship W2075329969A5042440695 @default.
• W2075329969 hasAuthorship W2075329969A5050592402 @default.
• W2075329969 hasAuthorship W2075329969A5081776412 @default.
• W2075329969 hasBestOaLocation W20753299692 @default.
• W2075329969 hasConcept C104317684 @default.
• W2075329969 hasConcept C121738310 @default.
• W2075329969 hasConcept C127716648 @default.
• W2075329969 hasConcept C15744967 @default.
• W2075329969 hasConcept C164659718 @default.
• W2075329969 hasConcept C169760540 @default.
• W2075329969 hasConcept C170493617 @default.
• W2075329969 hasConcept C182704531 @default.
• W2075329969 hasConcept C195794163 @default.
• W2075329969 hasConcept C25274449 @default.
• W2075329969 hasConcept C2779715522 @default.
• W2075329969 hasConcept C2781161787 @default.
• W2075329969 hasConcept C44752575 @default.
• W2075329969 hasConcept C529278444 @default.
• W2075329969 hasConcept C54355233 @default.
• W2075329969 hasConcept C62478195 @default.
• W2075329969 hasConcept C77957584 @default.
• W2075329969 hasConcept C86803240 @default.
• W2075329969 hasConcept C90934575 @default.
• W2075329969 hasConcept C95444343 @default.
• W2075329969 hasConcept C98229152 @default.
• W2075329969 hasConceptScore W2075329969C104317684 @default.
• W2075329969 hasConceptScore W2075329969C121738310 @default.
• W2075329969 hasConceptScore W2075329969C127716648 @default.
• W2075329969 hasConceptScore W2075329969C15744967 @default.
• W2075329969 hasConceptScore W2075329969C164659718 @default.
• W2075329969 hasConceptScore W2075329969C169760540 @default.
• W2075329969 hasConceptScore W2075329969C170493617 @default.
• W2075329969 hasConceptScore W2075329969C182704531 @default.
• W2075329969 hasConceptScore W2075329969C195794163 @default.
• W2075329969 hasConceptScore W2075329969C25274449 @default.
• W2075329969 hasConceptScore W2075329969C2779715522 @default.
• W2075329969 hasConceptScore W2075329969C2781161787 @default.
• W2075329969 hasConceptScore W2075329969C44752575 @default.
• W2075329969 hasConceptScore W2075329969C529278444 @default.
• W2075329969 hasConceptScore W2075329969C54355233 @default.
• W2075329969 hasConceptScore W2075329969C62478195 @default.
• W2075329969 hasConceptScore W2075329969C77957584 @default.
• W2075329969 hasConceptScore W2075329969C86803240 @default.
• W2075329969 hasConceptScore W2075329969C90934575 @default.
• W2075329969 hasConceptScore W2075329969C95444343 @default.
• W2075329969 hasConceptScore W2075329969C98229152 @default.
• W2075329969 hasLocation W20753299691 @default.
• W2075329969 hasLocation W20753299692 @default.
• W2075329969 hasLocation W20753299693 @default.
• W2075329969 hasLocation W20753299694 @default.

• next