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- W2075331483 abstract "Guanine nucleotide-binding (G) proteins, Gs and Golf mediate the increase in cAMP formation through the activation of adenylyl cyclases. The developmental profiles of Gs, Golf and adenylyl cyclases were determined in mouse striatum and whole brain using immunobloting with specific antisera. Gs and the 115 kDa and 150 kDa adenylyl cyclases were present at the earliest age tested, embryonic day (E) 14.5 Golf and the 160 kDa adenylyl cyclase emerged in parallel, postnatally; during this period the increase in the relative abundance of the 150 kDa was observed. Gpp[NH]p activated Gs/Golf in a dose dependent manner, with a smaller response observed in embryos compared to adults. Mn2+ and forskolin activated the adenylyl cyclases and this activation increased during development. At E 14.5, maximal activation with Mn2+ and forskolin elicited a similar increase in cAMP levels, but from postnatal day 1, a nearly two fold higher response was obtained with forskolin compared to Mn2+; at the same time the 160 kDa adenylyl cyclase was detected. These data suggest that the appearance of certain forms of stimulatory G proteins was developmentally correlated with the expression of specific adenylyl cyclases." @default.
- W2075331483 created "2016-06-24" @default.
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- W2075331483 date "1994-04-01" @default.
- W2075331483 modified "2023-09-26" @default.
- W2075331483 title "Developmental changes in Gs and Golf proteins and adenylyl cyclases in mouse brain membranes" @default.
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- W2075331483 doi "https://doi.org/10.1016/0006-8993(94)90007-8" @default.
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