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• W2075341349 startingPage "177" @default.
• W2075341349 abstract "In the post-absorptive state, ammonia is produced in equal amounts in the small and large bowel. Small intestinal synthesis of ammonia is related to amino acid breakdown, whereas large bowel ammonia production is caused by bacterial breakdown of amino acids and urea. The contribution of the gut to the hyperammonemic state observed during liver failure is mainly due to portacaval shunting and not the result of changes in the metabolism of ammonia in the gut. Patients with liver disease have reduced urea synthesis capacity and reduced peri-venous glutamine synthesis capacity, resulting in reduced capacity to detoxify ammonia in the liver. The kidneys produce ammonia but adapt to liver failure in experimental portacaval shunting by reducing ammonia release into the systemic circulation. The kidneys have the ability to switch from net ammonia production to net ammonia excretion, which is beneficial for the hyperammonemic patient. Data in experimental animals suggest that the kidneys could have a major role in post-feeding and post-haemorrhagic hyperammonemia.During hyperammonemia, muscle takes up ammonia and plays a major role in (temporarily) detoxifying ammonia to glutamine. Net uptake of ammonia by the brain occurs in patients and experimental animals with acute and chronic liver failure. Concomitant release of glutamine has been demonstrated in experimental animals, together with large increases of the cerebral cortex ammonia and glutamine concentrations. In this review we will discuss interorgan trafficking of ammonia during acute and chronic liver failure. Interorgan glutamine metabolism is also briefly discussed, since glutamine synthesis from glutamate and ammonia is an important alternative pathway of ammonia detoxification. The main ammonia producing organs are the intestines and the kidneys, whereas the major ammonia consuming organs are the liver and the muscle." @default.
• W2075341349 created "2016-06-24" @default.
• W2075341349 creator A5019509998 @default.
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• W2075341349 creator A5041852736 @default.
• W2075341349 creator A5047324691 @default.
• W2075341349 creator A5073459667 @default.
• W2075341349 date "2002-08-01" @default.
• W2075341349 modified "2023-10-16" @default.
• W2075341349 title "Interorgan ammonia metabolism in liver failure" @default.
• W2075341349 cites W108712373 @default.
• W2075341349 cites W109284476 @default.
• W2075341349 cites W1516678679 @default.
• W2075341349 cites W1549234706 @default.
• W2075341349 cites W1592254411 @default.
• W2075341349 cites W1596308403 @default.
• W2075341349 cites W1695988613 @default.
• W2075341349 cites W1781242772 @default.
• W2075341349 cites W1785497696 @default.
• W2075341349 cites W1848248203 @default.
• W2075341349 cites W1865027666 @default.
• W2075341349 cites W1875174011 @default.
• W2075341349 cites W189428430 @default.
• W2075341349 cites W1924395043 @default.
• W2075341349 cites W1942398216 @default.
• W2075341349 cites W1965385770 @default.
• W2075341349 cites W1966661600 @default.
• W2075341349 cites W1968179612 @default.
• W2075341349 cites W1968807182 @default.
• W2075341349 cites W1973542958 @default.
• W2075341349 cites W1974828316 @default.
• W2075341349 cites W1976474638 @default.
• W2075341349 cites W1979292721 @default.
• W2075341349 cites W1984089779 @default.
• W2075341349 cites W1986025103 @default.
• W2075341349 cites W1987080089 @default.
• W2075341349 cites W1987956458 @default.
• W2075341349 cites W1988970110 @default.
• W2075341349 cites W1990994515 @default.
• W2075341349 cites W1994555844 @default.
• W2075341349 cites W1995880424 @default.
• W2075341349 cites W1999384973 @default.
• W2075341349 cites W2000268422 @default.
• W2075341349 cites W2001239172 @default.
• W2075341349 cites W2002739050 @default.
• W2075341349 cites W2003045986 @default.
• W2075341349 cites W2003332242 @default.
• W2075341349 cites W2007462231 @default.
• W2075341349 cites W2013893940 @default.
• W2075341349 cites W2016600396 @default.
• W2075341349 cites W2019363793 @default.
• W2075341349 cites W2019723624 @default.
• W2075341349 cites W2020184246 @default.
• W2075341349 cites W2023087026 @default.
• W2075341349 cites W2027973870 @default.
• W2075341349 cites W2033501677 @default.
• W2075341349 cites W2036304270 @default.
• W2075341349 cites W2038183520 @default.
• W2075341349 cites W2039636675 @default.
• W2075341349 cites W2042618869 @default.
• W2075341349 cites W2045849369 @default.
• W2075341349 cites W2047172111 @default.
• W2075341349 cites W2054341520 @default.
• W2075341349 cites W2055041361 @default.
• W2075341349 cites W2060708905 @default.
• W2075341349 cites W2061538287 @default.
• W2075341349 cites W2067984680 @default.
• W2075341349 cites W2071106723 @default.
• W2075341349 cites W2073218335 @default.
• W2075341349 cites W2075477912 @default.
• W2075341349 cites W2080224915 @default.
• W2075341349 cites W2080756388 @default.
• W2075341349 cites W2082524841 @default.
• W2075341349 cites W2084575052 @default.
• W2075341349 cites W2086873275 @default.
• W2075341349 cites W2088659799 @default.
• W2075341349 cites W2089841034 @default.
• W2075341349 cites W2091241793 @default.
• W2075341349 cites W2095079971 @default.
• W2075341349 cites W2095521923 @default.
• W2075341349 cites W2110164053 @default.
• W2075341349 cites W2112597838 @default.
• W2075341349 cites W2118375664 @default.
• W2075341349 cites W2124783409 @default.
• W2075341349 cites W2132276505 @default.
• W2075341349 cites W2145130695 @default.
• W2075341349 cites W2150170509 @default.
• W2075341349 cites W2153064507 @default.
• W2075341349 cites W2154082725 @default.
• W2075341349 cites W2159044433 @default.
• W2075341349 cites W2161661283 @default.
• W2075341349 cites W2164609058 @default.
• W2075341349 cites W2165480177 @default.
• W2075341349 cites W2168363979 @default.
• W2075341349 cites W2170974856 @default.
• W2075341349 cites W2177855681 @default.
• W2075341349 cites W2233990435 @default.
• W2075341349 cites W2255012317 @default.

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