FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075344513> ?p ?o ?g. }

• W2075344513 endingPage "9701" @default.
• W2075344513 startingPage "9695" @default.
• W2075344513 abstract "Artificial enzymes capable of achieving tunable catalytic activity through stimuli control of enzymatic structure transition are of significance in biosensor and biomedicine research. Herein we report a novel smart glutathione peroxidise (GPx) mimic with modulatory catalytic activity based on redox-induced supramolecular self-assembly. First, an amphiphilic Fmoc-phenylalanine-based selenide was designed and synthesized, which can self-assemble into nanospheres (NSs) in aqueous solution. The NSs demonstrate extremely low GPx activity. Upon the oxidation of hydroperoxides (ROOH), the selenide can be quickly transformed into the selenoxide form. The change of the molecular structure induces complete morphology transition of the self-assemblies from NSs to nanotubes (NTs), resulting in great enhancement in the GPx catalytic activity. Under the reduction of GSH, the selenoxide can be further reversibly reduced back into the selenide; therefore the reversible switch between the NSs and NTs can be successfully accomplished. The relationship between the catalytic activity and enzymatic structure was also investigated. The dual response nature makes this mimic play roles of both a sensor and a GPx enzyme at the same time, which can auto-detect the signal of ROOH and then auto-change its activity to achieve quick or slow/no scavenging of ROOH. The dynamic balance of ROOH is vital in organisms, in which an appropriate amount of ROOH does benefit to the metabolism, whereas surplus ROOH can cause oxidative damage of the cell instead and this smart mimic is of remarkable significance. We expect that such a mimic can be developed into an effective antioxidant drug and provide a new platform for the construction of intelligent artificial enzymes with multiple desirable properties." @default.
• W2075344513 created "2016-06-24" @default.
• W2075344513 creator A5005466911 @default.
• W2075344513 creator A5018103480 @default.
• W2075344513 creator A5026628307 @default.
• W2075344513 creator A5027528821 @default.
• W2075344513 creator A5037636474 @default.
• W2075344513 creator A5038906848 @default.
• W2075344513 creator A5040636566 @default.
• W2075344513 creator A5075798289 @default.
• W2075344513 creator A5086664647 @default.
• W2075344513 creator A5089219310 @default.
• W2075344513 date "2014-10-13" @default.
• W2075344513 modified "2023-09-27" @default.
• W2075344513 title "Redox control of GPx catalytic activity through mediating self-assembly of Fmoc-phenylalanine selenide into switchable supramolecular architectures" @default.
• W2075344513 cites W152089085 @default.
• W2075344513 cites W1974163766 @default.
• W2075344513 cites W1986798646 @default.
• W2075344513 cites W1988069848 @default.
• W2075344513 cites W1992390260 @default.
• W2075344513 cites W1999014341 @default.
• W2075344513 cites W1999705428 @default.
• W2075344513 cites W2002175342 @default.
• W2075344513 cites W2002449018 @default.
• W2075344513 cites W2004559711 @default.
• W2075344513 cites W2005517353 @default.
• W2075344513 cites W2008207378 @default.
• W2075344513 cites W2011336077 @default.
• W2075344513 cites W2022636317 @default.
• W2075344513 cites W2026461087 @default.
• W2075344513 cites W2037082758 @default.
• W2075344513 cites W2037621579 @default.
• W2075344513 cites W2045160074 @default.
• W2075344513 cites W2047726172 @default.
• W2075344513 cites W2047804693 @default.
• W2075344513 cites W2051192107 @default.
• W2075344513 cites W2051862132 @default.
• W2075344513 cites W2056470333 @default.
• W2075344513 cites W2067656252 @default.
• W2075344513 cites W2071195046 @default.
• W2075344513 cites W2096239455 @default.
• W2075344513 cites W2107244611 @default.
• W2075344513 cites W2114775998 @default.
• W2075344513 cites W2116550515 @default.
• W2075344513 cites W2130054501 @default.
• W2075344513 cites W2146075973 @default.
• W2075344513 cites W2151639536 @default.
• W2075344513 cites W2168203225 @default.
• W2075344513 cites W2170828597 @default.
• W2075344513 cites W2320560283 @default.
• W2075344513 cites W2330243608 @default.
• W2075344513 cites W2496470675 @default.
• W2075344513 cites W4244089250 @default.
• W2075344513 cites W4253984787 @default.
• W2075344513 doi "https://doi.org/10.1039/c4sm02030h" @default.
• W2075344513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25366375" @default.
• W2075344513 hasPublicationYear "2014" @default.
• W2075344513 type Work @default.
• W2075344513 sameAs 2075344513 @default.
• W2075344513 citedByCount "24" @default.
• W2075344513 countsByYear W20753445132015 @default.
• W2075344513 countsByYear W20753445132016 @default.
• W2075344513 countsByYear W20753445132017 @default.
• W2075344513 countsByYear W20753445132018 @default.
• W2075344513 countsByYear W20753445132019 @default.
• W2075344513 countsByYear W20753445132020 @default.
• W2075344513 countsByYear W20753445132021 @default.
• W2075344513 countsByYear W20753445132022 @default.
• W2075344513 countsByYear W20753445132023 @default.
• W2075344513 crossrefType "journal-article" @default.
• W2075344513 hasAuthorship W2075344513A5005466911 @default.
• W2075344513 hasAuthorship W2075344513A5018103480 @default.
• W2075344513 hasAuthorship W2075344513A5026628307 @default.
• W2075344513 hasAuthorship W2075344513A5027528821 @default.
• W2075344513 hasAuthorship W2075344513A5037636474 @default.
• W2075344513 hasAuthorship W2075344513A5038906848 @default.
• W2075344513 hasAuthorship W2075344513A5040636566 @default.
• W2075344513 hasAuthorship W2075344513A5075798289 @default.
• W2075344513 hasAuthorship W2075344513A5086664647 @default.
• W2075344513 hasAuthorship W2075344513A5089219310 @default.
• W2075344513 hasConcept C160756335 @default.
• W2075344513 hasConcept C161790260 @default.
• W2075344513 hasConcept C178790620 @default.
• W2075344513 hasConcept C185592680 @default.
• W2075344513 hasConcept C21951064 @default.
• W2075344513 hasConcept C2777016790 @default.
• W2075344513 hasConcept C2777431362 @default.
• W2075344513 hasConcept C2778004101 @default.
• W2075344513 hasConcept C32909587 @default.
• W2075344513 hasConcept C515207424 @default.
• W2075344513 hasConcept C553756173 @default.
• W2075344513 hasConcept C55493867 @default.
• W2075344513 hasConcept C55904794 @default.
• W2075344513 hasConcept C93275456 @default.
• W2075344513 hasConceptScore W2075344513C160756335 @default.
• W2075344513 hasConceptScore W2075344513C161790260 @default.
• W2075344513 hasConceptScore W2075344513C178790620 @default.
• W2075344513 hasConceptScore W2075344513C185592680 @default.

• next