FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075344860> ?p ?o ?g. }

• W2075344860 endingPage "154" @default.
• W2075344860 startingPage "146" @default.
• W2075344860 abstract "Glutamate neurotransmission plays critical roles in normal central nervous system (CNS) function, neurodegenerative diseases, and neurotrauma. We determined whether glutamate signaling could be evoked within the anesthetized normal adult rat CNS with clinically relevant peripheral stimulation and recorded (at >1 Hz) with glutamate-sensitive, ceramic microelectrode arrays (MEAs). Basal glutamate levels and both forelimb cutaneous and electrical stimulation-evoked glutamate release were measured within the cuneate nucleus, a relay of the mammalian dorsal columns somatosensory system. The MEAs with triangular, sharp-point tips were more effective at tissue penetration than the flat, blunt tips. Basal glutamate levels of 2.1 ± 4.4 μM (mean ± SD, n = 10 animals) were detected from 150 μm to 1200 μm below the brainstem dorsal surface. Cutaneous evoked glutamate signals showed an amplitude of 1.1 ± 1.1 μM and a duration of 7.3 ± 6.5 s (26 signals, n = 6). Electrically evoked signals, like cutaneous ones, were both rapid and slowly rising. Electrically evoked signals, especially those evoked by stimulation trains, were more reproducible and had an amplitude of 1.2 ± 1.4 μM, duration of 19.4 ± 17.3 s, and latency from stimulus onset of 21.3 ± 21.5 s (25 signals, n = 4). In contrast to cutaneous stimulation, glutamate signals evoked by electrical stimulation had longer durations and were recorded primarily in the middle and ventral cuneate nuclei. Importantly, both cutaneous and electrical stimulation of the contralateral forelimb and hindlimbs did not evoke glutamate signaling. With the use of MEAs, these results show, for the first time, somatosensory-pathway specific changes in glutamate levels during peripheral cutaneous and electrical stimulation." @default.
• W2075344860 created "2016-06-24" @default.
• W2075344860 creator A5012507846 @default.
• W2075344860 creator A5015817902 @default.
• W2075344860 creator A5037708891 @default.
• W2075344860 date "2012-07-01" @default.
• W2075344860 modified "2023-10-06" @default.
• W2075344860 title "Cutaneous and electrically evoked glutamate signaling in the adult rat somatosensory system" @default.
• W2075344860 cites W1686397783 @default.
• W2075344860 cites W1965372184 @default.
• W2075344860 cites W1966007526 @default.
• W2075344860 cites W1975016302 @default.
• W2075344860 cites W1977500396 @default.
• W2075344860 cites W1978221430 @default.
• W2075344860 cites W1979783417 @default.
• W2075344860 cites W1982478459 @default.
• W2075344860 cites W1985615006 @default.
• W2075344860 cites W1991950630 @default.
• W2075344860 cites W1994438243 @default.
• W2075344860 cites W2001458880 @default.
• W2075344860 cites W2009575963 @default.
• W2075344860 cites W2012924135 @default.
• W2075344860 cites W2014359932 @default.
• W2075344860 cites W2022996208 @default.
• W2075344860 cites W2024253104 @default.
• W2075344860 cites W2029681544 @default.
• W2075344860 cites W2030295531 @default.
• W2075344860 cites W2034357089 @default.
• W2075344860 cites W2036666857 @default.
• W2075344860 cites W2038249200 @default.
• W2075344860 cites W2040871722 @default.
• W2075344860 cites W2042357530 @default.
• W2075344860 cites W2043414076 @default.
• W2075344860 cites W2051495138 @default.
• W2075344860 cites W2055508174 @default.
• W2075344860 cites W2058350784 @default.
• W2075344860 cites W2059026830 @default.
• W2075344860 cites W2065375190 @default.
• W2075344860 cites W2074332811 @default.
• W2075344860 cites W2074774221 @default.
• W2075344860 cites W2075342404 @default.
• W2075344860 cites W2079958431 @default.
• W2075344860 cites W2087071782 @default.
• W2075344860 cites W2091806199 @default.
• W2075344860 cites W2096198839 @default.
• W2075344860 cites W2102090711 @default.
• W2075344860 cites W2105434751 @default.
• W2075344860 cites W2116106538 @default.
• W2075344860 cites W2155644915 @default.
• W2075344860 cites W2161400543 @default.
• W2075344860 doi "https://doi.org/10.1016/j.jneumeth.2012.05.013" @default.
• W2075344860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22627377" @default.
• W2075344860 hasPublicationYear "2012" @default.
• W2075344860 type Work @default.
• W2075344860 sameAs 2075344860 @default.
• W2075344860 citedByCount "14" @default.
• W2075344860 countsByYear W20753448602013 @default.
• W2075344860 countsByYear W20753448602014 @default.
• W2075344860 countsByYear W20753448602015 @default.
• W2075344860 countsByYear W20753448602016 @default.
• W2075344860 countsByYear W20753448602017 @default.
• W2075344860 countsByYear W20753448602018 @default.
• W2075344860 countsByYear W20753448602019 @default.
• W2075344860 countsByYear W20753448602020 @default.
• W2075344860 countsByYear W20753448602021 @default.
• W2075344860 crossrefType "journal-article" @default.
• W2075344860 hasAuthorship W2075344860A5012507846 @default.
• W2075344860 hasAuthorship W2075344860A5015817902 @default.
• W2075344860 hasAuthorship W2075344860A5037708891 @default.
• W2075344860 hasConcept C105702510 @default.
• W2075344860 hasConcept C126322002 @default.
• W2075344860 hasConcept C169760540 @default.
• W2075344860 hasConcept C170493617 @default.
• W2075344860 hasConcept C172497186 @default.
• W2075344860 hasConcept C185592680 @default.
• W2075344860 hasConcept C24998067 @default.
• W2075344860 hasConcept C2776559050 @default.
• W2075344860 hasConcept C2777786120 @default.
• W2075344860 hasConcept C2778646069 @default.
• W2075344860 hasConcept C529278444 @default.
• W2075344860 hasConcept C551621295 @default.
• W2075344860 hasConcept C61174792 @default.
• W2075344860 hasConcept C71924100 @default.
• W2075344860 hasConcept C86803240 @default.
• W2075344860 hasConceptScore W2075344860C105702510 @default.
• W2075344860 hasConceptScore W2075344860C126322002 @default.
• W2075344860 hasConceptScore W2075344860C169760540 @default.
• W2075344860 hasConceptScore W2075344860C170493617 @default.
• W2075344860 hasConceptScore W2075344860C172497186 @default.
• W2075344860 hasConceptScore W2075344860C185592680 @default.
• W2075344860 hasConceptScore W2075344860C24998067 @default.
• W2075344860 hasConceptScore W2075344860C2776559050 @default.
• W2075344860 hasConceptScore W2075344860C2777786120 @default.
• W2075344860 hasConceptScore W2075344860C2778646069 @default.
• W2075344860 hasConceptScore W2075344860C529278444 @default.
• W2075344860 hasConceptScore W2075344860C551621295 @default.
• W2075344860 hasConceptScore W2075344860C61174792 @default.
• W2075344860 hasConceptScore W2075344860C71924100 @default.

• next