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- W2075347733 abstract "You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation1 Apr 2014MP32-18 TESTOSTERONE REPLACEMENT THERAPY IMPROVES THE QUALITY OF LIFE OF HYPOGONADAL MEN DIAGNOSED WITH “LATE ONSET HYPOGONADISM” – ASSESSED BY VALIDATED QUESTIONNAIRES Dany-Jan Yassin, Aksam Yassin, and Peter Hammerer Dany-Jan YassinDany-Jan Yassin More articles by this author , Aksam YassinAksam Yassin More articles by this author , and Peter HammererPeter Hammerer More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.948AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Physiologic testosterone maintains libido, nocturnal tumescence and a good erectile function. Studies have shown that sub-physiologic testosterone levels affect the psychosomatic and psychomotor domains. We hypothesized that testosterone causes sustained long-term health related quality of life (HRQoL). METHODS 261 patients (mean age 58 years) diagnosed with late onset hypogonadism (LOH) were treated with long-acting intramuscular testosterone undecanoate (TU). Treatment was started approximately 3 weeks after the diagnosis and continued at three month intervals after a “loading dose” interval of six weeks. Patients were entered into a cumulative registry database once they had received treatment for at least one year and followed for up to five years. In this analysis, we followed health quality indicators over time since the beginning of testosterone replacement therapy (TRT). The outcomes studied were the International Prostate Symptom Score (IPSS), the International Index of Erectile Function-5 (IIEF-5), the Aging Males’ Symptoms (AMS) scale, and joint and muscle pain. Concomitantly total testosterone levels were measured. Joint and muscle pain was recorded in a binary fashion. The rest of the parameters were continuous parameters. Means of the IPSS, IIEF-5, AMS, and testosterone were calculated in every visit (Tx). The percentage of patients reporting joint and muscle pain was also calculated at every Tx. Barographs were used to report the percentages of those who answered “yes” to “presence of joint and muscle pain”. Linear plots were used to represent the trend of the means of the continuous variables over time. RESULTS Means of IPSS and AMS decreased with a steep slope within the first 3 months. Means of IIEF-5 and total testosterone increased with an equal slope during the same period. All 4 parameters reached a plateau at around 3-6 months. Muscle pain percentage decreased steeply over the first year and continued to decrease with a smaller coefficient until the last follow-up date. CONCLUSIONS This descriptive analysis shows a clear improvement in the psychomotor, psychosomatic, urinary and sexual domains. As physiologic total testosterone is reached and maintained, IIEF, IPSS, and AMS plateau at a normal level. In addition, joint and muscle pain shows a sustained continuous improvement. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e337 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Dany-Jan Yassin More articles by this author Aksam Yassin More articles by this author Peter Hammerer More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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- W2075347733 title "MP32-18 TESTOSTERONE REPLACEMENT THERAPY IMPROVES THE QUALITY OF LIFE OF HYPOGONADAL MEN DIAGNOSED WITH “LATE ONSET HYPOGONADISM” – ASSESSED BY VALIDATED QUESTIONNAIRES" @default.
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