FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075353846> ?p ?o ?g. }

• W2075353846 endingPage "18508" @default.
• W2075353846 startingPage "18503" @default.
• W2075353846 abstract "AAA+ proteases are ATP-fueled machines that bind protein substrates via a degradation tag, unfold the molecule if necessary, and then translocate the polypeptide into a chamber for proteolysis. Tag recognition is normally viewed as a passive reaction. By contrast, for the AAA+ Lon protease, we show that degron tags are also regulatory elements that determine protease activity levels. Indeed, different tags fused to the same protein change degradation speeds and energetic efficiencies by 10-fold or more. Degron binding to multiple sites in the Lon hexamer appears to differentially stabilize specific enzyme conformations, including one with high protease and low ATPase activity, and results in positively cooperative degradation. These allosteric mechanisms allow Lon to operate in either a fast or slow proteolysis mode, according to specific physiological needs, and may help maximize degradation of misfolded proteins following stress-induced denaturation." @default.
• W2075353846 created "2016-06-24" @default.
• W2075353846 creator A5012368829 @default.
• W2075353846 creator A5016269061 @default.
• W2075353846 date "2009-11-03" @default.
• W2075353846 modified "2023-10-02" @default.
• W2075353846 title "Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine" @default.
• W2075353846 cites W1575568920 @default.
• W2075353846 cites W1972825620 @default.
• W2075353846 cites W1988419268 @default.
• W2075353846 cites W1989185632 @default.
• W2075353846 cites W1992602287 @default.
• W2075353846 cites W1994944725 @default.
• W2075353846 cites W1998093640 @default.
• W2075353846 cites W2011332001 @default.
• W2075353846 cites W2014951926 @default.
• W2075353846 cites W2035363308 @default.
• W2075353846 cites W2046882513 @default.
• W2075353846 cites W2074654002 @default.
• W2075353846 cites W2090668757 @default.
• W2075353846 cites W2092405233 @default.
• W2075353846 cites W2097424323 @default.
• W2075353846 cites W2099196052 @default.
• W2075353846 cites W2100470175 @default.
• W2075353846 cites W2106461141 @default.
• W2075353846 cites W2110227935 @default.
• W2075353846 cites W2121523774 @default.
• W2075353846 cites W2133210247 @default.
• W2075353846 cites W2134915935 @default.
• W2075353846 cites W2140595019 @default.
• W2075353846 cites W2142341344 @default.
• W2075353846 cites W2159716299 @default.
• W2075353846 cites W2159823053 @default.
• W2075353846 cites W4254281572 @default.
• W2075353846 cites W69814808 @default.
• W2075353846 doi "https://doi.org/10.1073/pnas.0910392106" @default.
• W2075353846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2774003" @default.
• W2075353846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19841274" @default.
• W2075353846 hasPublicationYear "2009" @default.
• W2075353846 type Work @default.
• W2075353846 sameAs 2075353846 @default.
• W2075353846 citedByCount "72" @default.
• W2075353846 countsByYear W20753538462012 @default.
• W2075353846 countsByYear W20753538462013 @default.
• W2075353846 countsByYear W20753538462014 @default.
• W2075353846 countsByYear W20753538462015 @default.
• W2075353846 countsByYear W20753538462016 @default.
• W2075353846 countsByYear W20753538462017 @default.
• W2075353846 countsByYear W20753538462018 @default.
• W2075353846 countsByYear W20753538462019 @default.
• W2075353846 countsByYear W20753538462020 @default.
• W2075353846 countsByYear W20753538462021 @default.
• W2075353846 countsByYear W20753538462022 @default.
• W2075353846 countsByYear W20753538462023 @default.
• W2075353846 crossrefType "journal-article" @default.
• W2075353846 hasAuthorship W2075353846A5012368829 @default.
• W2075353846 hasAuthorship W2075353846A5016269061 @default.
• W2075353846 hasBestOaLocation W20753538461 @default.
• W2075353846 hasConcept C101635128 @default.
• W2075353846 hasConcept C104317684 @default.
• W2075353846 hasConcept C109110057 @default.
• W2075353846 hasConcept C12554922 @default.
• W2075353846 hasConcept C134459356 @default.
• W2075353846 hasConcept C159047783 @default.
• W2075353846 hasConcept C166342909 @default.
• W2075353846 hasConcept C181199279 @default.
• W2075353846 hasConcept C182220744 @default.
• W2075353846 hasConcept C185592680 @default.
• W2075353846 hasConcept C189754071 @default.
• W2075353846 hasConcept C23265538 @default.
• W2075353846 hasConcept C2522874641 @default.
• W2075353846 hasConcept C25602115 @default.
• W2075353846 hasConcept C2775895488 @default.
• W2075353846 hasConcept C2776625791 @default.
• W2075353846 hasConcept C2776714187 @default.
• W2075353846 hasConcept C2777833472 @default.
• W2075353846 hasConcept C2779679103 @default.
• W2075353846 hasConcept C2781307694 @default.
• W2075353846 hasConcept C2992195973 @default.
• W2075353846 hasConcept C41008148 @default.
• W2075353846 hasConcept C55493867 @default.
• W2075353846 hasConcept C76155785 @default.
• W2075353846 hasConcept C86803240 @default.
• W2075353846 hasConceptScore W2075353846C101635128 @default.
• W2075353846 hasConceptScore W2075353846C104317684 @default.
• W2075353846 hasConceptScore W2075353846C109110057 @default.
• W2075353846 hasConceptScore W2075353846C12554922 @default.
• W2075353846 hasConceptScore W2075353846C134459356 @default.
• W2075353846 hasConceptScore W2075353846C159047783 @default.
• W2075353846 hasConceptScore W2075353846C166342909 @default.
• W2075353846 hasConceptScore W2075353846C181199279 @default.
• W2075353846 hasConceptScore W2075353846C182220744 @default.
• W2075353846 hasConceptScore W2075353846C185592680 @default.
• W2075353846 hasConceptScore W2075353846C189754071 @default.
• W2075353846 hasConceptScore W2075353846C23265538 @default.
• W2075353846 hasConceptScore W2075353846C2522874641 @default.
• W2075353846 hasConceptScore W2075353846C25602115 @default.
• W2075353846 hasConceptScore W2075353846C2775895488 @default.

• next