FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075358801> ?p ?o ?g. }

• W2075358801 endingPage "697.e3" @default.
• W2075358801 startingPage "690" @default.
• W2075358801 abstract "ObjectivesSystemic inflammatory responses are a major cause of morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass. However, the underlying molecular mechanisms for systemic inflammation in response to cardiopulmonary bypass are poorly understood.MethodsA porcine model was established to study the signaling pathways that promote systemic inflammation in response to cardiac surgery with cardiopulmonary bypass under well-controlled experimental conditions. The influence of sulforaphane, an anti-inflammatory compound derived from green vegetables, on inflammation and injury in response to cardiopulmonary bypass was also studied. Intracellular staining and flow cytometry were performed to measure phosphorylation of p38 mitogen-activated protein kinase and the transcription factor nuclear factor-κB in granulocytes and mononuclear cells.ResultsSurgery with cardiopulmonary bypass for 1 to 2 hours enhanced phosphorylation of p38 (2.5-fold) and nuclear factor-κB (1.6-fold) in circulating mononuclear cells. Cardiopulmonary bypass also modified granulocytes by activating nuclear factor-κB (1.6-fold), whereas p38 was not altered. Histologic analyses revealed that cardiopulmonary bypass promoted acute tubular necrosis. Pretreatment of animals with sulforaphane reduced p38 (90% reduction) and nuclear factor-κB (50% reduction) phosphorylation in leukocytes and protected kidneys from injury.ConclusionsSystemic inflammatory responses after cardiopulmonary bypass were associated with activation of p38 and nuclear factor-κB pathways in circulating leukocytes. Inflammatory responses to cardiopulmonary bypass can be reduced by sulforaphane, which reduced leukocyte activation and protected against renal injury. Systemic inflammatory responses are a major cause of morbidity and mortality in patients undergoing cardiac surgery with cardiopulmonary bypass. However, the underlying molecular mechanisms for systemic inflammation in response to cardiopulmonary bypass are poorly understood. A porcine model was established to study the signaling pathways that promote systemic inflammation in response to cardiac surgery with cardiopulmonary bypass under well-controlled experimental conditions. The influence of sulforaphane, an anti-inflammatory compound derived from green vegetables, on inflammation and injury in response to cardiopulmonary bypass was also studied. Intracellular staining and flow cytometry were performed to measure phosphorylation of p38 mitogen-activated protein kinase and the transcription factor nuclear factor-κB in granulocytes and mononuclear cells. Surgery with cardiopulmonary bypass for 1 to 2 hours enhanced phosphorylation of p38 (2.5-fold) and nuclear factor-κB (1.6-fold) in circulating mononuclear cells. Cardiopulmonary bypass also modified granulocytes by activating nuclear factor-κB (1.6-fold), whereas p38 was not altered. Histologic analyses revealed that cardiopulmonary bypass promoted acute tubular necrosis. Pretreatment of animals with sulforaphane reduced p38 (90% reduction) and nuclear factor-κB (50% reduction) phosphorylation in leukocytes and protected kidneys from injury. Systemic inflammatory responses after cardiopulmonary bypass were associated with activation of p38 and nuclear factor-κB pathways in circulating leukocytes. Inflammatory responses to cardiopulmonary bypass can be reduced by sulforaphane, which reduced leukocyte activation and protected against renal injury." @default.
• W2075358801 created "2016-06-24" @default.
• W2075358801 creator A5009957313 @default.
• W2075358801 creator A5011926544 @default.
• W2075358801 creator A5012175357 @default.
• W2075358801 creator A5023953753 @default.
• W2075358801 creator A5034351934 @default.
• W2075358801 creator A5036969945 @default.
• W2075358801 creator A5044513022 @default.
• W2075358801 creator A5049562243 @default.
• W2075358801 creator A5054764500 @default.
• W2075358801 creator A5059349051 @default.
• W2075358801 creator A5064172105 @default.
• W2075358801 creator A5084161740 @default.
• W2075358801 creator A5084948280 @default.
• W2075358801 creator A5089871096 @default.
• W2075358801 creator A5091035425 @default.
• W2075358801 creator A5065572685 @default.
• W2075358801 date "2014-08-01" @default.
• W2075358801 modified "2023-09-28" @default.
• W2075358801 title "Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass" @default.
• W2075358801 cites W1972995842 @default.
• W2075358801 cites W1975827192 @default.
• W2075358801 cites W1990985882 @default.
• W2075358801 cites W1991201692 @default.
• W2075358801 cites W1991631628 @default.
• W2075358801 cites W2006389304 @default.
• W2075358801 cites W2043845684 @default.
• W2075358801 cites W2055448873 @default.
• W2075358801 cites W2059944694 @default.
• W2075358801 cites W2067288493 @default.
• W2075358801 cites W207029473 @default.
• W2075358801 cites W2073547744 @default.
• W2075358801 cites W2089226005 @default.
• W2075358801 cites W2096099635 @default.
• W2075358801 cites W2096204372 @default.
• W2075358801 cites W2099280799 @default.
• W2075358801 cites W2102128464 @default.
• W2075358801 cites W2108685233 @default.
• W2075358801 cites W2114364427 @default.
• W2075358801 cites W2115809399 @default.
• W2075358801 cites W2119991580 @default.
• W2075358801 cites W2134219545 @default.
• W2075358801 cites W2137836635 @default.
• W2075358801 cites W2139564374 @default.
• W2075358801 cites W2148119611 @default.
• W2075358801 cites W2158220397 @default.
• W2075358801 cites W2158969445 @default.
• W2075358801 cites W2163380502 @default.
• W2075358801 cites W2336219802 @default.
• W2075358801 doi "https://doi.org/10.1016/j.jtcvs.2013.12.048" @default.
• W2075358801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24521949" @default.
• W2075358801 hasPublicationYear "2014" @default.
• W2075358801 type Work @default.
• W2075358801 sameAs 2075358801 @default.
• W2075358801 citedByCount "24" @default.
• W2075358801 countsByYear W20753588012015 @default.
• W2075358801 countsByYear W20753588012016 @default.
• W2075358801 countsByYear W20753588012017 @default.
• W2075358801 countsByYear W20753588012018 @default.
• W2075358801 countsByYear W20753588012019 @default.
• W2075358801 countsByYear W20753588012020 @default.
• W2075358801 countsByYear W20753588012021 @default.
• W2075358801 countsByYear W20753588012022 @default.
• W2075358801 crossrefType "journal-article" @default.
• W2075358801 hasAuthorship W2075358801A5009957313 @default.
• W2075358801 hasAuthorship W2075358801A5011926544 @default.
• W2075358801 hasAuthorship W2075358801A5012175357 @default.
• W2075358801 hasAuthorship W2075358801A5023953753 @default.
• W2075358801 hasAuthorship W2075358801A5034351934 @default.
• W2075358801 hasAuthorship W2075358801A5036969945 @default.
• W2075358801 hasAuthorship W2075358801A5044513022 @default.
• W2075358801 hasAuthorship W2075358801A5049562243 @default.
• W2075358801 hasAuthorship W2075358801A5054764500 @default.
• W2075358801 hasAuthorship W2075358801A5059349051 @default.
• W2075358801 hasAuthorship W2075358801A5064172105 @default.
• W2075358801 hasAuthorship W2075358801A5065572685 @default.
• W2075358801 hasAuthorship W2075358801A5084161740 @default.
• W2075358801 hasAuthorship W2075358801A5084948280 @default.
• W2075358801 hasAuthorship W2075358801A5089871096 @default.
• W2075358801 hasAuthorship W2075358801A5091035425 @default.
• W2075358801 hasBestOaLocation W20753588011 @default.
• W2075358801 hasConcept C126322002 @default.
• W2075358801 hasConcept C17991360 @default.
• W2075358801 hasConcept C203014093 @default.
• W2075358801 hasConcept C2776252253 @default.
• W2075358801 hasConcept C2776914184 @default.
• W2075358801 hasConcept C2778881276 @default.
• W2075358801 hasConcept C2780841255 @default.
• W2075358801 hasConcept C502942594 @default.
• W2075358801 hasConcept C71924100 @default.
• W2075358801 hasConceptScore W2075358801C126322002 @default.
• W2075358801 hasConceptScore W2075358801C17991360 @default.
• W2075358801 hasConceptScore W2075358801C203014093 @default.
• W2075358801 hasConceptScore W2075358801C2776252253 @default.
• W2075358801 hasConceptScore W2075358801C2776914184 @default.
• W2075358801 hasConceptScore W2075358801C2778881276 @default.
• W2075358801 hasConceptScore W2075358801C2780841255 @default.

• next