Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075366948> ?p ?o ?g. }
- W2075366948 endingPage "10724" @default.
- W2075366948 startingPage "10719" @default.
- W2075366948 abstract "Gaseous messengers, nitric oxide and carbon monoxide, have been implicated in O 2 sensing by the carotid body, a sensory organ that monitors arterial blood O 2 levels and stimulates breathing in response to hypoxia. We now show that hydrogen sulfide (H 2 S) is a physiologic gasotransmitter of the carotid body, enhancing its sensory response to hypoxia. Glomus cells, the site of O 2 sensing in the carotid body, express cystathionine γ-lyase (CSE), an H 2 S-generating enzyme, with hypoxia increasing H 2 S generation in a stimulus-dependent manner. Mice with genetic deletion of CSE display severely impaired carotid body response and ventilatory stimulation to hypoxia, as well as a loss of hypoxia-evoked H 2 S generation. Pharmacologic inhibition of CSE elicits a similar phenotype in mice and rats. Hypoxia-evoked H 2 S generation in the carotid body seems to require interaction of CSE with hemeoxygenase-2, which generates carbon monoxide. CSE is also expressed in neonatal adrenal medullary chromaffin cells of rats and mice whose hypoxia-evoked catecholamine secretion is greatly attenuated by CSE inhibitors and in CSE knockout mice." @default.
- W2075366948 created "2016-06-24" @default.
- W2075366948 creator A5004128762 @default.
- W2075366948 creator A5010883631 @default.
- W2075366948 creator A5013158023 @default.
- W2075366948 creator A5020208893 @default.
- W2075366948 creator A5031114280 @default.
- W2075366948 creator A5039262140 @default.
- W2075366948 creator A5060388980 @default.
- W2075366948 creator A5064414704 @default.
- W2075366948 date "2010-05-24" @default.
- W2075366948 modified "2023-10-16" @default.
- W2075366948 title "H <sub>2</sub> S mediates O <sub>2</sub> sensing in the carotid body" @default.
- W2075366948 cites W119076208 @default.
- W2075366948 cites W1586119176 @default.
- W2075366948 cites W1921020717 @default.
- W2075366948 cites W1964320031 @default.
- W2075366948 cites W1973592190 @default.
- W2075366948 cites W1974980569 @default.
- W2075366948 cites W1987326893 @default.
- W2075366948 cites W1991930915 @default.
- W2075366948 cites W2007206583 @default.
- W2075366948 cites W2008430621 @default.
- W2075366948 cites W2014641242 @default.
- W2075366948 cites W2015407072 @default.
- W2075366948 cites W2025905719 @default.
- W2075366948 cites W2027512930 @default.
- W2075366948 cites W2032411573 @default.
- W2075366948 cites W2038796859 @default.
- W2075366948 cites W2046788982 @default.
- W2075366948 cites W2048900931 @default.
- W2075366948 cites W2054064167 @default.
- W2075366948 cites W2062188620 @default.
- W2075366948 cites W2063325639 @default.
- W2075366948 cites W2072540192 @default.
- W2075366948 cites W2097567364 @default.
- W2075366948 cites W2098262530 @default.
- W2075366948 cites W2101952797 @default.
- W2075366948 cites W2106659867 @default.
- W2075366948 cites W2111331308 @default.
- W2075366948 cites W2125239443 @default.
- W2075366948 cites W2139704316 @default.
- W2075366948 cites W2153376781 @default.
- W2075366948 cites W2160176954 @default.
- W2075366948 cites W2255076808 @default.
- W2075366948 cites W2270470133 @default.
- W2075366948 doi "https://doi.org/10.1073/pnas.1005866107" @default.
- W2075366948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890835" @default.
- W2075366948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20556885" @default.
- W2075366948 hasPublicationYear "2010" @default.
- W2075366948 type Work @default.
- W2075366948 sameAs 2075366948 @default.
- W2075366948 citedByCount "328" @default.
- W2075366948 countsByYear W20753669482012 @default.
- W2075366948 countsByYear W20753669482013 @default.
- W2075366948 countsByYear W20753669482014 @default.
- W2075366948 countsByYear W20753669482015 @default.
- W2075366948 countsByYear W20753669482016 @default.
- W2075366948 countsByYear W20753669482017 @default.
- W2075366948 countsByYear W20753669482018 @default.
- W2075366948 countsByYear W20753669482019 @default.
- W2075366948 countsByYear W20753669482020 @default.
- W2075366948 countsByYear W20753669482021 @default.
- W2075366948 countsByYear W20753669482022 @default.
- W2075366948 countsByYear W20753669482023 @default.
- W2075366948 crossrefType "journal-article" @default.
- W2075366948 hasAuthorship W2075366948A5004128762 @default.
- W2075366948 hasAuthorship W2075366948A5010883631 @default.
- W2075366948 hasAuthorship W2075366948A5013158023 @default.
- W2075366948 hasAuthorship W2075366948A5020208893 @default.
- W2075366948 hasAuthorship W2075366948A5031114280 @default.
- W2075366948 hasAuthorship W2075366948A5039262140 @default.
- W2075366948 hasAuthorship W2075366948A5060388980 @default.
- W2075366948 hasAuthorship W2075366948A5064414704 @default.
- W2075366948 hasBestOaLocation W20753669481 @default.
- W2075366948 hasConcept C126322002 @default.
- W2075366948 hasConcept C134018914 @default.
- W2075366948 hasConcept C178790620 @default.
- W2075366948 hasConcept C185592680 @default.
- W2075366948 hasConcept C236027 @default.
- W2075366948 hasConcept C24998067 @default.
- W2075366948 hasConcept C2778113364 @default.
- W2075366948 hasConcept C519581460 @default.
- W2075366948 hasConcept C540031477 @default.
- W2075366948 hasConcept C71924100 @default.
- W2075366948 hasConcept C7836513 @default.
- W2075366948 hasConceptScore W2075366948C126322002 @default.
- W2075366948 hasConceptScore W2075366948C134018914 @default.
- W2075366948 hasConceptScore W2075366948C178790620 @default.
- W2075366948 hasConceptScore W2075366948C185592680 @default.
- W2075366948 hasConceptScore W2075366948C236027 @default.
- W2075366948 hasConceptScore W2075366948C24998067 @default.
- W2075366948 hasConceptScore W2075366948C2778113364 @default.
- W2075366948 hasConceptScore W2075366948C519581460 @default.
- W2075366948 hasConceptScore W2075366948C540031477 @default.
- W2075366948 hasConceptScore W2075366948C71924100 @default.
- W2075366948 hasConceptScore W2075366948C7836513 @default.
- W2075366948 hasIssue "23" @default.