FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075371016> ?p ?o ?g. }

• W2075371016 endingPage "1184" @default.
• W2075371016 startingPage "1177" @default.
• W2075371016 abstract "Caffeine is consumed worldwide to enhance wakefulness, but the cellular mechanisms are poorly understood. Caffeine blocks adenosine receptors suggesting that adenosine decreases cortical arousal. Given the widespread innervation of the cerebral cortex by thalamic fibers, adenosine receptors on thalamocortical terminals could provide an efficient method of limiting thalamic activation of the cortex. Using a mouse thalamocortical slice preparation and whole-cell patch clamp recordings, we examined whether thalamocortical terminals are modulated by adenosine receptors. Bath application of adenosine decreased excitatory postsynaptic currents elicited by stimulation of the ventrobasal thalamus. Thalamocortical synapses onto inhibitory and excitatory neurons were equally affected by adenosine. Adenosine also increased the paired pulse ratio and the coefficient of variation of the excitatory postsynaptic currents, suggesting that adenosine decreased glutamate release. The inhibition produced by adenosine was reversed by a selective antagonist of adenosine A1 receptors (8-cyclopentyltheophylline) and mimicked by a selective A1 receptor agonist (N6-cyclopentyladenosine). Our results indicate that thalamocortical excitation is regulated by presynaptic adenosine A1 receptors and provide a mechanism by which increased adenosine levels can directly reduce cortical excitability." @default.
• W2075371016 created "2016-06-24" @default.
• W2075371016 creator A5000678835 @default.
• W2075371016 creator A5051755979 @default.
• W2075371016 date "2006-01-01" @default.
• W2075371016 modified "2023-10-17" @default.
• W2075371016 title "Adenosine A1 receptors decrease thalamic excitation of inhibitory and excitatory neurons in the barrel cortex" @default.
• W2075371016 cites W1489513029 @default.
• W2075371016 cites W1568660743 @default.
• W2075371016 cites W1589379916 @default.
• W2075371016 cites W1644616682 @default.
• W2075371016 cites W1676571406 @default.
• W2075371016 cites W1740234100 @default.
• W2075371016 cites W1949141612 @default.
• W2075371016 cites W1976495888 @default.
• W2075371016 cites W1978317269 @default.
• W2075371016 cites W1978936152 @default.
• W2075371016 cites W1980809345 @default.
• W2075371016 cites W1985556856 @default.
• W2075371016 cites W1988189610 @default.
• W2075371016 cites W1994376562 @default.
• W2075371016 cites W2000527091 @default.
• W2075371016 cites W2007990537 @default.
• W2075371016 cites W2020098765 @default.
• W2075371016 cites W2029325913 @default.
• W2075371016 cites W2032121387 @default.
• W2075371016 cites W2032445862 @default.
• W2075371016 cites W2032924239 @default.
• W2075371016 cites W2045815714 @default.
• W2075371016 cites W2049220930 @default.
• W2075371016 cites W2052804852 @default.
• W2075371016 cites W2056661320 @default.
• W2075371016 cites W2057157090 @default.
• W2075371016 cites W2061388579 @default.
• W2075371016 cites W2065428236 @default.
• W2075371016 cites W2066015662 @default.
• W2075371016 cites W2068198569 @default.
• W2075371016 cites W2069558219 @default.
• W2075371016 cites W2071366993 @default.
• W2075371016 cites W2072070847 @default.
• W2075371016 cites W2073577145 @default.
• W2075371016 cites W2081548183 @default.
• W2075371016 cites W2083143366 @default.
• W2075371016 cites W2086369628 @default.
• W2075371016 cites W2086846760 @default.
• W2075371016 cites W2089036949 @default.
• W2075371016 cites W2095364366 @default.
• W2075371016 cites W2106861254 @default.
• W2075371016 cites W2110258654 @default.
• W2075371016 cites W2113960406 @default.
• W2075371016 cites W2119989547 @default.
• W2075371016 cites W2127025004 @default.
• W2075371016 cites W2137731628 @default.
• W2075371016 cites W2145758516 @default.
• W2075371016 cites W2146288322 @default.
• W2075371016 cites W2153446323 @default.
• W2075371016 cites W2156780983 @default.
• W2075371016 cites W2166317443 @default.
• W2075371016 cites W2176759914 @default.
• W2075371016 cites W2407214542 @default.
• W2075371016 cites W3021526609 @default.
• W2075371016 cites W3087885511 @default.
• W2075371016 cites W4295831928 @default.
• W2075371016 doi "https://doi.org/10.1016/j.neuroscience.2005.10.022" @default.
• W2075371016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3698575" @default.
• W2075371016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16343787" @default.
• W2075371016 hasPublicationYear "2006" @default.
• W2075371016 type Work @default.
• W2075371016 sameAs 2075371016 @default.
• W2075371016 citedByCount "45" @default.
• W2075371016 countsByYear W20753710162012 @default.
• W2075371016 countsByYear W20753710162013 @default.
• W2075371016 countsByYear W20753710162014 @default.
• W2075371016 countsByYear W20753710162015 @default.
• W2075371016 countsByYear W20753710162016 @default.
• W2075371016 countsByYear W20753710162017 @default.
• W2075371016 countsByYear W20753710162018 @default.
• W2075371016 countsByYear W20753710162019 @default.
• W2075371016 countsByYear W20753710162020 @default.
• W2075371016 countsByYear W20753710162021 @default.
• W2075371016 countsByYear W20753710162022 @default.
• W2075371016 crossrefType "journal-article" @default.
• W2075371016 hasAuthorship W2075371016A5000678835 @default.
• W2075371016 hasAuthorship W2075371016A5051755979 @default.
• W2075371016 hasBestOaLocation W20753710162 @default.
• W2075371016 hasConcept C112592302 @default.
• W2075371016 hasConcept C134018914 @default.
• W2075371016 hasConcept C169760540 @default.
• W2075371016 hasConcept C170493617 @default.
• W2075371016 hasConcept C17077164 @default.
• W2075371016 hasConcept C182683403 @default.
• W2075371016 hasConcept C185592680 @default.
• W2075371016 hasConcept C197341189 @default.
• W2075371016 hasConcept C2776991684 @default.
• W2075371016 hasConcept C2778500429 @default.
• W2075371016 hasConcept C2778938600 @default.
• W2075371016 hasConcept C2780634109 @default.
• W2075371016 hasConcept C2910581834 @default.

• next