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• W2075431337 abstract "For a virus population within its host, two important levels of structure can be considered: multiple cell types which can be infected, and tissue types or body compartments which may be coupled via movement. We develop a model with both types of structure. Migration between compartments can create sources and sinks within the virus population, where realized viral growth rate and abundance is lowered in some compartments compared to what would be observed in isolation. Using both analytical and numerical methods, we investigate how this within-host spatial structure affects the conditions for persistent viral infection. We find that migration between compartments makes the establishment of infection more difficult than it would be in the absence of migration, implying that within-host spatial structure combined with viral movement decreases the likelihood of viral establishment. If migration is symmetrical and compartments are heterogeneous, an increase in migration rates between compartments generally makes establishment less likely. This may help to explain the tissue specificity observed for many viruses. There are, however, important exceptions to this result. These include circumstances where the virus initially invades a compartment that is unfavorable to population growth and migration is necessary to infect other parts of the host body. Stochastic aspects of viral establishment may also favor increased migration as it tends to dampen the amplitude of fluctuations in population size during the initial transient phase of establishment." @default.
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• W2075431337 date "2005-02-01" @default.
• W2075431337 modified "2023-09-25" @default.
• W2075431337 title "Viral infection in internally structured hosts. I. Conditions for persistent infection" @default.
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• W2075431337 doi "https://doi.org/10.1016/j.jtbi.2004.08.023" @default.
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