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• W2075449215 abstract "T U E S D A Y 983 Rhinitis Questionnaire Items Predict Physician-Diagnosed Allergic Rhinitis in Children H. Kim, L. Levin, G. K. LeMasters, D. I. Bernstein; Department of Medicine, University of Cincinnati, Cincinnati, OH, Department of Environmental Health, University of Cincinnati, Cincinnati, OH. RATIONALE:Questionnaire items used to evaluate allergic rhinitis (AR) in epidemiologic studies of children have not been clinically validated. METHODS: Children from an atopic birth cohort were evaluated at age 7 using medical questionnaires, physical exams, and skin prick tests (SPT) with 15 aeroallergens (AG). Predictor variables included parental questionnaire responses to presence of: 1) rhinitis symptoms without a cold; 2) ocular symptoms; 3) hay fever symptoms; and 4) seasonality of symptoms. The primary outcome was physician diagnosed AR (PDAR) with positive SPT to 15 AG. Odds ratios (OR) for the primary outcome were calculated using logistic regression; 582/764 children in the cohort were analyzed. RESULTS: PDAR and monosensitization was not predicted by any questionnaire items. PDAR and positive SPT to 3 (OR 2.44, p50.05) or 6 (OR511.68, p50.02) AG was best predicted by presence of rhinitis symptoms. Seasonality increased prediction of PDAR and SPT to 3 (OR52.49, p50.03) or 6 (OR517.27, p50.007) AG, but presence of ocular symptoms increased prediction of PDAR with 6 SPT only (OR527.0, p50.002). PDAR and SPT to 2 (OR52.35, p50.03), 5 (OR56.03, p50.006), or 6 (OR58.05, p50.004) AG was best predicted by presence of hay fever. CONCLUSIONS:Use of questionnaire items best predicts AR in children with polysensitization to AGs, and are less useful for predicting AR in monosensitized children. Including seasonality, ocular symptoms, and hay fever can increase prediction of PDAR with polysensitization. 984 Aeroallergen Sensitization in Children with Allergic Rhinitis: Prevalence and Risk Associations W. Loh, W. Chiang, W. Liew, H. Lim, A. Goh, M. I. Kidon, B. Abhilash, H. Tan, Y. Chen, O. Chay; KK Women’s and Children’s Hospital, Paediatric Allergy and Immunology, Singapore, SINGAPORE, KK Women’s and Children’s Hospital, Department of Paediatric Otolaryngology, Singapore, SINGAPORE, Singapore Clinical Research Institute, Biopolis, Singapore, SINGAPORE. RATIONAL: To describe differences between allergic rhinitis (AR) and nonallergic rhinitis (NAR) from a tertiary Paediatric Hospital in Singapore. METHODS: A total of 6600 subjects, 6mths -19years, were referred to Allergy,Ortholaryngology or Pulmonary physicians for skin prick testing for allergen associated allergies. Theywere included if therewas parent reported persistent allergic rhinitis (>4 weeks) or doctor diagnosed allergic rhinitis. All subjectscompletedaquestionnaireandunderwenta standardized inhalantpanel. RESULTS: Themean age of presentation was 7.82 years (range, 0.6 19y) and 64% were male. Of all subjects, 55.3% have asthma, 33.9% allergic dermatitis and 16.1% allergic conjunctivitis. Aerosensitization was documented in a third presenting with AR under age of 2 years. In the AR subjects, 25%were sensitized before the age of 6 years. Therewas no difference in both groups of children with AR or NAR for use of antihistamines (36%), nasal steroids (3.2%) and ventolin (22.4% vs 21.7%). However, NAR was more likely to be treated with Singulaire. AR patients were more likely to require adjunct therapy with inhaled corticosteroids (51.2% vs 43.2% P<0.0001) suggesting lower respiratory airways disease was more significant. Presence of AR predicted for higher risk of admissions for asthma (9.1% vs 6%, P<0.0001). CONCLUSIONS: NAR accounts for 26% of all rhinitis presenting after 6 years old. Males are (OR 1.5 ;CI 1.39 1.77) more likely to demonstrate AR rather than NAR compared with females. In general, subjects with AR more often suffer fromasthmawithmore asthma relatedadmissions anddrugallergy. 985 Chronic Rhinitis in Pediatric Patients: Epidemiologic Analysis of One Cohort E. A. Erwin, R. A. Faust, T. A. E. Platts-Mills, L. Borish; Nationwide Children’s Hospital, Columbus, OH, The Ohio State University, Columbus, OH, University of Virginia Asthma and Allergic Diseases Center, Charlottesville, VA. RATIONALE: Nonallergic rhinitis is a vaguely defined and poorly understoodentity especially amongpediatric patients.Ourobjectivewas to identify clinical features that may distinguish phenotypes of allergic and nonallergic patients and to evaluate the utility of some current diagnostic modalities. METHODS: We reviewed medical records for 151 pediatric patients with chronic rhinitis, evaluated in a multidisciplinary allergy and otolaryngology clinic.Results obtainedby standardhistory, validatedquestionnaire (SN-5), epicutaneous allergy testing, acoustic rhinometry, and sinus CTwere compared. RESULTS:Nasal congestionwas themost commonprimary presenting complaint (62%). Among subjects having a positive allergy test, associated eye symptomsweremore frequent (X, p50.01) and responses to the SN-5 allergic domain were higher (t test, p50.02). Sinus CT scores were similar among allergic and nonallergic subjects anddidnot correlatewith nasal symptomscores. In nonallergic subjects, quality of life ratings weakly correlated with sinus CT scores (r50.4, p50.05). By using acoustic rhinometry, absolute mean cross sectional area (MCA) was similar among allergic and nonallergic subjects and did not correlate with symptom scores (p50.8 and p50.6 respectively). Distinct groups of nonallergic patients with itchy eyes (n512), with frequent cold symptoms (n54), and chronic sinus disease (n52) were observed. CONCLUSIONS: By using currently available clinical testing, it is difficult to distinguish allergic and nonallergic rhinitis, but associated eye symptoms and questionnaire responses can be predictive of allergy. Measurements from acoustic rhinometry and sinus CT suggest that physical obstruction and sinus disease are not related to nasal symptoms." @default.
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• W2075449215 date "2011-02-01" @default.
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• W2075449215 title "Aeroallergen Sensitization in Children with Allergic Rhinitis: Prevalence and Risk Associations" @default.
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