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• W2075453630 endingPage "6966" @default.
• W2075453630 startingPage "6957" @default.
• W2075453630 abstract "Nitric oxide (NO) is known to be a potent inhibitor of platelet activation and adhesion. Healthy endothelial cells that line the inner walls of all blood vessels exhibit a NO flux of 0.5–4 × 10−10 mol cm−2 min−1 that helps prevent thrombosis. Materials with a NO flux that is equivalent to this level are expected to exhibit similar anti-thrombotic properties. In this study, five biomedical grade polymers doped with S-nitroso-N-acetylpenicillamine (SNAP) were investigated for their potential to control the release of NO from the SNAP within the polymers, and further control the release of SNAP itself. SNAP in the Elast-eon E2As polymer creates an inexpensive, homogeneous coating that can locally deliver NO (via thermal and photochemical reactions) as well slowly release SNAP. Furthermore, SNAP is surprisingly stable in the E2As polymer, retaining 82% of the initial SNAP after 2 months storage at 37 °C. The E2As polymer containing SNAP was coated on the walls of extracorporeal circulation (ECC) circuits and exposed to 4 h blood flow in a rabbit model of extracorporeal circulation to examine the effects on platelet count, platelet function, clot area, and fibrinogen adsorption. After 4 h, platelet count was preserved at 100 ± 7% of baseline for the SNAP/E2As coated loops, compared to 60 ± 6% for E2As control circuits (n = 4). The SNAP/E2As coating also reduced the thrombus area when compared to the control (2.3 ± 0.6 and 3.4 ± 1.1 pixels/cm2, respectively). The results suggest that the new SNAP/E2As coating has potential to improve the thromboresistance of intravascular catheters, grafts, and other blood-contacting medical devices, and exhibits excellent storage stability compared to previously reported NO release polymeric materials." @default.
• W2075453630 created "2016-06-24" @default.
• W2075453630 creator A5010565408 @default.
• W2075453630 creator A5024724191 @default.
• W2075453630 creator A5034009146 @default.
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• W2075453630 date "2013-09-01" @default.
• W2075453630 modified "2023-10-03" @default.
• W2075453630 title "Long-term nitric oxide release and elevated temperature stability with S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As polymer" @default.
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• W2075453630 doi "https://doi.org/10.1016/j.biomaterials.2013.05.063" @default.
• W2075453630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3729938" @default.
• W2075453630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23777908" @default.
• W2075453630 hasPublicationYear "2013" @default.
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