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• W2075457034 startingPage "161" @default.
• W2075457034 abstract "Dynamin, the product of the shibire gene of Drosophila, is a GTPase critically required for endocytosis. Some studies have suggested a functional link between dynamin and the actin cytoskeleton. This link is of special interest, because there is evidence implicating actin dynamics in endocytosis. Here we show that endogenous dynamin 2, as well as green fluorescence protein fusion proteins of both dynamin 1 and 2, is present in actin comets generated by Listeria or by type I PIP kinase (PIPK) overexpression. In PIPK-induced tails, dynamin is further enriched at the interface between the tails and the moving organelles. Dynamin mutants harboring mutations in the GTPase domain inhibited nucleation of actin tails induced by PIPK and moderately reduced their speed. Although dynamin localization to the tails required its proline-rich domain, expression of a dynamin mutant lacking this domain also diminished tail formation. In addition, this mutant disrupted a membrane-associated actin scaffold (podosome rosette) previously shown to include dynamin. These findings suggest that dynamin is part of a protein network that controls nucleation of actin from membranes. At endocytic sites, dynamin may couple the fission reaction to the polymerization of an actin pool that functions in the separation of the endocytic vesicles from the plasma membrane." @default.
• W2075457034 created "2016-06-24" @default.
• W2075457034 creator A5012424400 @default.
• W2075457034 creator A5037459294 @default.
• W2075457034 date "2002-01-08" @default.
• W2075457034 modified "2023-09-26" @default.
• W2075457034 title "Dynamin at actin tails" @default.
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• W2075457034 doi "https://doi.org/10.1073/pnas.012607799" @default.
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