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- W2075458807 abstract "Abstract 1. 1. The biogenesis of the guanido groups of hirudonine (diamidino-spermidine), diguanidine isolated from the leech, Hirudo medicinalis L., has been investigated. 2. 2. Hirudonine is synthesized in vivo by transamidination reactions involving arginine: when arginine-amidino-C14 was injected into leeches, there was a significant incorporation of radioactivity into hirudonine, which was isolated as the crystallized sulphate. 3. 3. Partial degradation of the radioactive hirudonine isolated from leeches injected with labeled arginine for a twenty-four hours' period indicated that about half of the total radioactivity was located in the amidine group of the agmatine moiety of hirudonine. 4. 4. The significance of these results and the possible biosynthetic process are discussed." @default.
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- W2075458807 date "1962-11-01" @default.
- W2075458807 modified "2023-09-26" @default.
- W2075458807 title "Biogenese de l'hirudonine—I" @default.
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- W2075458807 doi "https://doi.org/10.1016/0010-406x(62)90096-8" @default.
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