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- W2075490622 endingPage "106" @default.
- W2075490622 startingPage "88" @default.
- W2075490622 abstract "Since its discovery two decades ago, the activation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth factors has resulted in it becoming one of the most well-studied intracellular signalling networks. The field has progressed from the identification of the individual components to high-resolution crystal structures of both JAK and STAT, and an understanding of the complexities of the molecular activation and deactivation cycle which results in a diverse, yet highly specific and regulated pattern of transcriptional responses. While there is still more to learn, we now appreciate how disruption and deregulation of this pathway can result in clinical disease and look forward to adoption of the next generation of JAK inhibitors in routine clinical treatment." @default.
- W2075490622 created "2016-06-24" @default.
- W2075490622 creator A5034924216 @default.
- W2075490622 creator A5080514134 @default.
- W2075490622 date "2012-02-20" @default.
- W2075490622 modified "2023-10-05" @default.
- W2075490622 title "Biology and significance of the JAK/STAT signalling pathways" @default.
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