FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2075492029> ?p ?o ?g. }

• W2075492029 endingPage "389" @default.
• W2075492029 startingPage "381" @default.
• W2075492029 abstract "Tumour Necrosis Factor alpha (TNF) is a pleiotropic pro-inflammatory cytokine with known vascular permeabilising activity. It is employed during isolated limb perfusion to enhance delivery of chemotherapeutic drugs into tumour tissue. The use of conditionally-replicating lytic viruses, so called ‘oncolytic virotherapy’, provides a new approach to cancer treatment that is currently limited by the low efficiency of extravasation of viral particles into tumours. We report here evidence that TNF significantly enhances the delivery of virus particles through the endothelial layer to allow access to tumour cells both in vitro and in vivo. Intravenous administration of TNF resulted in a 3- to 6-fold increase in EL4 tumour uptake of Evans Blue/Albumin, adenovirus and long-circulating polymer coated adenovirus. Interestingly, endothelial permeabilisation could be suppressed in vitro and in vivo by Y-27632, a Rho kinase inhibitor, without inhibiting viral infection. These data indicate that TNF can enhance the delivery of virus particles into tumours through a Rho A/Rho kinase dependent mechanism and may be a valuable strategy for increasing the delivery of oncolytic viruses and other therapeutic agents." @default.
• W2075492029 created "2016-06-24" @default.
• W2075492029 creator A5003131937 @default.
• W2075492029 creator A5016577781 @default.
• W2075492029 creator A5019319557 @default.
• W2075492029 creator A5025452500 @default.
• W2075492029 creator A5026184651 @default.
• W2075492029 creator A5032131181 @default.
• W2075492029 creator A5040423991 @default.
• W2075492029 creator A5061590219 @default.
• W2075492029 creator A5072231925 @default.
• W2075492029 date "2011-12-01" @default.
• W2075492029 modified "2023-10-03" @default.
• W2075492029 title "Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway" @default.
• W2075492029 cites W1579129437 @default.
• W2075492029 cites W1887951286 @default.
• W2075492029 cites W1889451488 @default.
• W2075492029 cites W1890068101 @default.
• W2075492029 cites W1913785883 @default.
• W2075492029 cites W1949688967 @default.
• W2075492029 cites W1963827572 @default.
• W2075492029 cites W1974600730 @default.
• W2075492029 cites W1983387455 @default.
• W2075492029 cites W1997087774 @default.
• W2075492029 cites W2011063658 @default.
• W2075492029 cites W2016356298 @default.
• W2075492029 cites W2021199853 @default.
• W2075492029 cites W2029936621 @default.
• W2075492029 cites W2031539699 @default.
• W2075492029 cites W2032295238 @default.
• W2075492029 cites W2039003757 @default.
• W2075492029 cites W2051379819 @default.
• W2075492029 cites W2055477134 @default.
• W2075492029 cites W2072304704 @default.
• W2075492029 cites W2079852426 @default.
• W2075492029 cites W2090732350 @default.
• W2075492029 cites W2092527323 @default.
• W2075492029 cites W2111224621 @default.
• W2075492029 cites W2120680479 @default.
• W2075492029 cites W2126350489 @default.
• W2075492029 cites W2164617344 @default.
• W2075492029 cites W2316811173 @default.
• W2075492029 cites W2321451097 @default.
• W2075492029 cites W2336324298 @default.
• W2075492029 doi "https://doi.org/10.1016/j.jconrel.2011.08.022" @default.
• W2075492029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21884739" @default.
• W2075492029 hasPublicationYear "2011" @default.
• W2075492029 type Work @default.
• W2075492029 sameAs 2075492029 @default.
• W2075492029 citedByCount "49" @default.
• W2075492029 countsByYear W20754920292012 @default.
• W2075492029 countsByYear W20754920292013 @default.
• W2075492029 countsByYear W20754920292014 @default.
• W2075492029 countsByYear W20754920292015 @default.
• W2075492029 countsByYear W20754920292016 @default.
• W2075492029 countsByYear W20754920292017 @default.
• W2075492029 countsByYear W20754920292018 @default.
• W2075492029 countsByYear W20754920292019 @default.
• W2075492029 countsByYear W20754920292020 @default.
• W2075492029 countsByYear W20754920292021 @default.
• W2075492029 countsByYear W20754920292022 @default.
• W2075492029 countsByYear W20754920292023 @default.
• W2075492029 crossrefType "journal-article" @default.
• W2075492029 hasAuthorship W2075492029A5003131937 @default.
• W2075492029 hasAuthorship W2075492029A5016577781 @default.
• W2075492029 hasAuthorship W2075492029A5019319557 @default.
• W2075492029 hasAuthorship W2075492029A5025452500 @default.
• W2075492029 hasAuthorship W2075492029A5026184651 @default.
• W2075492029 hasAuthorship W2075492029A5032131181 @default.
• W2075492029 hasAuthorship W2075492029A5040423991 @default.
• W2075492029 hasAuthorship W2075492029A5061590219 @default.
• W2075492029 hasAuthorship W2075492029A5072231925 @default.
• W2075492029 hasConcept C150903083 @default.
• W2075492029 hasConcept C159047783 @default.
• W2075492029 hasConcept C17991360 @default.
• W2075492029 hasConcept C202751555 @default.
• W2075492029 hasConcept C203014093 @default.
• W2075492029 hasConcept C207001950 @default.
• W2075492029 hasConcept C2522874641 @default.
• W2075492029 hasConcept C2777283488 @default.
• W2075492029 hasConcept C2778690821 @default.
• W2075492029 hasConcept C2779540182 @default.
• W2075492029 hasConcept C502942594 @default.
• W2075492029 hasConcept C55493867 @default.
• W2075492029 hasConcept C71924100 @default.
• W2075492029 hasConcept C82210918 @default.
• W2075492029 hasConcept C86803240 @default.
• W2075492029 hasConceptScore W2075492029C150903083 @default.
• W2075492029 hasConceptScore W2075492029C159047783 @default.
• W2075492029 hasConceptScore W2075492029C17991360 @default.
• W2075492029 hasConceptScore W2075492029C202751555 @default.
• W2075492029 hasConceptScore W2075492029C203014093 @default.
• W2075492029 hasConceptScore W2075492029C207001950 @default.
• W2075492029 hasConceptScore W2075492029C2522874641 @default.
• W2075492029 hasConceptScore W2075492029C2777283488 @default.
• W2075492029 hasConceptScore W2075492029C2778690821 @default.
• W2075492029 hasConceptScore W2075492029C2779540182 @default.
• W2075492029 hasConceptScore W2075492029C502942594 @default.

• next