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- W2075494430 abstract "The calcium-activated potassium channel KCa3.1 is critically involved in the proliferation and migration of T cells, macrophages, dedifferentiated vascular smooth muscle cells and fibroblasts by regulating membrane potential and calcium influx. KCa3.1 has therefore been suggested as a potential therapeutic target for various diseases where activation and excessive proliferation of one or more of these cell types is involved in the pathology. Using the selective small molecule KCa3.1 blocker TRAM-34 as a pharmacological tool compound we previously demonstrated that KCa3.1 blockade prevents restenosis in both rats and pigs and reduces atherosclerosis development in ApoE-/- mice." @default.
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- W2075494430 date "2010-01-01" @default.
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- W2075494430 title "Kca3.1 Blockers as Potential New Drugs for the Prevention of Renal Fibrosis and Chronic Allograft Rejection" @default.
- W2075494430 doi "https://doi.org/10.1016/j.bpj.2009.12.676" @default.
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