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- W2075496593 abstract "AbstractThe peak III/I ratio of pyrene monomer fluorescence was used to characterize surface-induced insulin denaturation and aggregation. An indicator of the hydrophobicity of pyrene's microenvironment, the IIM ratio can be used to study self-association of amphipathic molecules. In sodium lauryl sulfate (NaLS), the III/I ratio was 0.71 below the critical micelle concentration (CMC) and increased to 0.98 when the concentration was above the CMC. When insulin was placed in a polystyrene cuvet for 2 days at 37°C, the IWI ratio decreased from 0.84 to 0.78. The decrease in III/I ratio corresponds to surface-induced denaturation of insulin which exposed pyrene to a more polar environment. Increasing the duration of incubation for up to 12 days increased the III/I ratio to 1.06. Increased hydrophobicity of pyrene's environment correlates with the self-association of insulin. Once the aggregates reached a critical size, they began precipitating as was evident by an increase in the turbidity (absorbance at 600 n..." @default.
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- W2075496593 date "1995-01-01" @default.
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- W2075496593 title "Photophysical Characterization of Insulin Denaturation and Aggregation at Hydrophobic Interfaces" @default.
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- W2075496593 doi "https://doi.org/10.3109/03639049509069255" @default.
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