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• W2075499127 startingPage "C941" @default.
• W2075499127 abstract "The rates of H 2 S and HS − transport across the human erythrocyte membrane were estimated by measuring rates of dissipation of pH gradients in media containing 250 μM H 2 S/HS − . Net acid efflux is caused by H 2 S/HS − acting analogously to CO 2 /HCO 3 − in the Jacobs-Stewart cycle. The steps are as follows: 1) H 2 S efflux through the lipid bilayer and/or a gas channel, 2) extracellular H 2 S deprotonation, 3) HS − influx in exchange for Cl − , catalyzed by the anion exchange protein AE1, and 4) intracellular HS − protonation. Net acid transport by the Cl − /HS − /H 2 S cycle is more efficient than by the Cl − /HCO 3 − /CO 2 cycle because of the rapid H 2 S-HS − interconversion in cells and medium. The rates of acid transport were analyzed by solving the mass flow equations for the cycle to produce estimates of the HS − and H 2 S transport rates. The data indicate that HS − is a very good substrate for AE1; the Cl − /HS − exchange rate is about one-third as rapid as Cl − /HCO 3 − exchange. The H 2 S permeability coefficient must also be high (>10 −2 cm/s, half time <0.003 s) to account for the pH equilibration data. The results imply that H 2 S and HS − enter erythrocytes very rapidly in the microcirculation of H 2 S-producing tissues, thereby acting as a sink for H 2 S and lowering the local extracellular concentration, and the fact that HS − is a substrate for a Cl − /HCO 3 − exchanger indicates that some effects of exogenous H 2 S/HS − may not result from a regulatory role of H 2 S but, rather, from net acid flux by H 2 S and HS − transport in a Jacobs-Stewart cycle." @default.
• W2075499127 created "2016-06-24" @default.
• W2075499127 creator A5057756099 @default.
• W2075499127 date "2013-11-01" @default.
• W2075499127 modified "2023-10-02" @default.
• W2075499127 title "Transport of H₂S and HS⁻across the human red blood cell membrane: rapid H₂S diffusion and AE1-mediated Cl⁻/HS⁻exchange" @default.
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• W2075499127 doi "https://doi.org/10.1152/ajpcell.00178.2013" @default.
• W2075499127 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4042536" @default.
• W2075499127 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23864610" @default.
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