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- W2075550827 abstract "THE effects of the benzodiazepine derivative GYKI 52466 on ischemia-evoked neurotransmitter amino acid release were evaluated in a rat four vessel occlusion model with cerebral cortical cups. Following intravenous GYKI 52466 administration (10 mg kg-1 bolus followed by 10 mg kg-1 60 min-1 infusion) glutamate, aspartate and GABA release into cerebral cortical superfusates was enhanced by ischemia to a comparable extent to that observed in control ischemic rats. These results suggest that the protective action of GYKI 52466 against cerebral cortical ischemic injury is unlikely to be due to a selective reduction in extracellular glutamate levels, but is rather, a result of the recognized ability of this compound to block non-NMDA receptors." @default.
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- W2075550827 date "1993-01-01" @default.
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- W2075550827 title "GYKI 52466 and ischemia-evoked neurotransmitter amino acid release from rat cerebral cortex" @default.
- W2075550827 doi "https://doi.org/10.1097/00001756-199301000-00029" @default.
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